| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
To identify genetic factors that might contribute to autoimmune pancreatitis, we identified the voltage-gated Kv1.3 channel protein regulated by KCNA3. We investigated its role in the pathogenesis, but found no significant association. Using genome wide association study, we found 25 candidate genes on 14 chromosomes, which are associated with susceptibility to autoimmune pancreatitis. We are confirming the association by fine mapping with SNPs within these genes.
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