Evaluation of effectiveness and safety of immune cell therapy for the unresectable locally advanced pancreatic cancer (Phase 2 trial)
| Project/Area Number |
20590806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya University |
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Principal Investigator |
HIROOKA Yoshiki Nagoya University, 医学部附属病院, 准教授 (50324413)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Hidemi 名古屋大学, 医学系研究科, 教授 (10215501)
ITOH Akihiro 名古屋大学, 医学系研究科, 講師 (30362239)
OHMIYA Nsoki 名古屋大学, 医学系研究科, 講師 (00335035)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 免疫細胞療法 / 切除不能局所進行膵癌 / 樹状細胞局注 / 未熟樹状細胞 / 超音波内視鏡下穿刺 / 腫瘍内局注 / CD8陽性リンパ球 / Foxp3陽性細胞 / 個別化治療 / 膵臓癌 / 免疫療法 / 樹状細胞療法 / 活性化リンパ球 / 遺伝子解析 / マイクロアレイ / ジェムザール |
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| Research Abstract |
For the unresectable locally advanced pancreatic cancer, immune cell therapy was conducted. Immature dendritic cells were directly injected the target tumor using endoscopic ultrasonography guidance. Immature dendritic cell sensitized by tumor lysate grew up to the mature dendritic cell with tumor specific immunity and demonstrated tumor specific immunotoxicity to the human pancreatic cancer for the first time.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer.2009
Author(s)
Hirooka Y, Itoh A, Kawashima H, Hara K, Nonogaki K, Kasugai T, Ohno E, Ishikawa T, Matsubara H, Ishigami M, Katano Y, Ohmiya N, Niwa Y, Yamamoto K, Kaneko T, Nieda M, Yokokawa K, Goto H.
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Journal Title
Pancreas. 38
Pages: 69-74
NAID
Related Report
Peer Reviewed
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[Journal Article] Diagnosis of pancreatic disorders using contrast-enhanced endoscopic ultrasonography and endoscopic elastography.2009
Author(s)
Hirooka Y, Itoh A, Kawashima H, Ohno E, Ishikawa T, Matsubara H, Itoh Y, Nakamura M, Miyahara R, Ohmiya N, Niwa Y, Ishigami M, Katano Y, Goto H.
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Journal Title
Clin Gastroenterol Hepatol. 7
Pages: 62-67
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
廣岡芳樹
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Journal Title
Advanced Therapeutic Endoscopy(東京医学社)
Pages: 958-963
Related Report
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