Pathogenetic mechanisms of autoimmune pancreatitis and sclerosing cholangitis
| Project/Area Number |
20590810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
OKAZAKI Kazuichi Kansai Medical University, 医学部, 教授 (70145126)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Koichi 関西医科大学, 医学部, 准教授 (70278638)
UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自己免疫性膵炎 / IgG4 / 硬化性胆管炎 / 動物モデル / 制御性T細胞 / IL-10 / Th17 / 原発性硬化性胆管炎 |
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| Research Abstract |
Our study clarified that the patients with IgG4-related autoimmune pancreatitis (AIP), and sclerosing cholangitis (SC) and animal experimental models showed autoimmune responses against carbonic anhydrase II (CA-II), lactoferrin and pancreatic secretory trypsin inhibitor (PSTI). Both Th1 and Th2, but not Th17 immune cells are involved in the development of these lesions. Moreover, regulatory T cells (Tregs), especially ICOS+Tregs are involved in IgG4 production in patients with IgG4-related AIP and SC.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis : an international multicentre study.2011
Author(s)
Sugumar A, Levy MJ, Kamisawa T, J M Webster G, Kim MH, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson GJ, Okazaki K, Pearson RK, Pereira SP, Petersen BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS, Chari ST
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Analysis of humoral immune response in experimental autoimmune pancreatitis in mice.2010
Author(s)
Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T
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Journal Title
Pancreas. 39(2)
Pages: 224-31
Related Report
Peer Reviewed
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[Journal Article] Primary sclerosing cholangitis with elevated serum IgG4 levels and/or infiltration of abundant IgG4-positive plasma cells.2010
Author(s)
Koyabu M, Uchida K, Fukata N, Kusuda T, Ikeura T, Sakaguchi Y, Yoshida K, Shimatani M, Fukui T, Matsushita M, Uemura Y, Kaibori M, Takaoka M, Nishio A, Okazaki K
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Journal Title
J Gastroenterol. 45(1)
Pages: 122-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases.2010
Author(s)
Koyabu M, Uchida K, Miyoshi H, Sakaguchi Y, Fukui T, Ikeda H, Takaoka M, Hirohara J, Nishio A, Uemura Y, Uemoto S, Okazaki K
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Journal Title
J Gastroenterol. 45(7)
Pages: 732-41
NAID
Related Report
Peer Reviewed
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[Journal Article] Idiopathic duct-centric pancreatitis (IDCP) with immunological studies.2010
Author(s)
Kusuda T, Uchida K, Satoi S, Koyabu M, Fukata N, Miyoshi H, Ikeura T, Sakaguchi Y, Yoshida K, Fukui T, Shimatani M, Matsushita M, Takaoka M, Nishio A, Uemura Y, Kwon AH, Okazaki K
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Journal Title
Intern Med. 49(23)
Pages: 2569-75
NAID
Related Report
Peer Reviewed
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[Journal Article] Long-term outcome of autoimmune pancreatitis.2009
Author(s)
Uchida K, Yazumi S, Nishio A, Kusuda T, Koyabu M, Fukata M, Miyoshi H, Sakaguchi Y, Fukui T, Matsushita M, Takaoka M, Okazaki K
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Journal Title
J Gastroenterol. 44(7)
Pages: 726-32
NAID
Related Report
Peer Reviewed
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[Journal Article] Standard steroid therapy for autoimmune pancreatitis.2009
Author(s)
Kamisawa T, Shimosegawa T, Okazaki K, Nishino T, Watanabe H, Kanno A, Okumura F, Nishikawa T, Kobayashi K, Ichiya T, Takatori H, Yamakita K, Kubota K, Hamano H, Okamura K, Hirano K, Ito T, Ko S, Omata M
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Journal Title
Gut. 58(11)
Pages: 1504-7
Related Report
Peer Reviewed
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[Journal Article] Japanese clinical guidelines for autoimmune pancreatitis.2009
Author(s)
Okazaki K, Kawa S, Kamisawa T, Ito T, Inui K, Irie H, Irisawa A, Kubo K, Notohara K, Hasebe O, Fujinaga Y, Ohara H, Tanaka S, Nishino T, Nishimori I, Nishiyama T, Suda K, Shiratori K, Shimosegawa T, Tanaka M
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Journal Title
Pancreas. 38(8)
Pages: 849-66
Related Report
Peer Reviewed
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