Prevention of esophageal stricture after endoscopic surgery using new drug delivery system

• Project/Area Number: 20590811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya University
• Principal Investigator: NIWA Yasumasa Nagoya University, 発がん制御研究部, 研究員 (20283442)
• Co-Investigator(Kenkyū-buntansha): GOTO Hidemi 名古屋大学, 大学院・医学系研究科, 教授 (10215501) ; NARITA Yuji 名古屋大学, 大学院・医学系研究科, 特任講師 (60378221) ; KATO Ryuji 名古屋大学, 大学院・工学研究科, 助教 (50377884) ; OHMIYA Naoki 名古屋大学, 医学部附属病院, 講師 (00335035)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 内科 / 消化管内視鏡治療 / 薬剤徐放 / 食道 / 内視鏡的粘膜切除術 / 術後狭窄 / 徐放化薬剤溶出担体

Research Abstract

Circumferential endoscopic surgery in the esophagus lead to esophageal stricture. This study demonstrated development of an endoscopically injectable controlled releasing anti-scarring drug delivery system, and verification of the efficacy of our strategy for prevention of esophageal stricture.

Research Products

• [Journal Article] Novel Strategy for Prevention of Esophageal Stricture after Endoscopic Surgery (2010)
  • Author(s): 丹羽康正、成田裕司、加藤竜司、後藤秀実, 他8名省略(1、2、3、7、8、9、10、11番目)
  • Journal Title: Hepato-Gastroenterology 57 Pages: 1150-1156
  • Peer Reviewed
• [Journal Article] Novel Strategy for Prevention of Esophageal Stricture after Endoscopic Surgery (2010)
  • Author(s): Mizutani T
  • Journal Title: Hepato-Gastroenterology Volume: 57 Pages: 1150-1156
  • Peer Reviewed
• [Presentation] 薬剤徐放性マイクロ中空カプセルドラッグデリバリーシステムを用いた瘢痕形成予防法の開発 (2011)
  • Author(s): 成田裕司、加藤竜司、後藤秀実, 他
  • Organizer: 日本再生医療学会
  • Place of Presentation: 東京都
  • Year and Date: 2011-03-01
• [Presentation] 薬剤徐放性マイクロ中空カプセルドラッグデリバリーシステムを用いた癒痕形成予防法の開発 (2011)
  • Author(s): 成田裕司
  • Organizer: 日本再生医療学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-03-01
• [Presentation] Endoscopically Injectable Anti-Searing Drug Delivery System for Prevention of Oesophageal Stricture after Aggressive Endoscopic Resection (2008)
  • Author(s): 丹羽康正, 他
  • Organizer: TERMIS-AP 2008
  • Place of Presentation: Taipei
  • Year and Date: 2008-11-07
• [Presentation] Novel strategy for prevention of oesophageal stricture after a ggressive endoscopic resection-Efficacy of the endoscopically injectable anti-searing drug delivery system (2008)
  • Author(s): 丹羽康正, 他
  • Organizer: 16^<th> UEGW 2008
  • Place of Presentation: Vienna
  • Year and Date: 2008-10-21