| Project/Area Number |
20590817
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Toyama |
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Principal Investigator |
INOUE Hiroshi University of Toyama, 大学院・医学薬学研究部(医学), 教授 (60151619)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Tadakazu 富山大学, 大学院・医学薬学研究部(医学), 助教 (10303215)
JOHO Shuji 富山大学, 大学病院, 助教 (90334721)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 心不全 / 交感神経活動 / 概日リズム / 化学反射感受性 |
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| Research Abstract |
This study was designed to determine abnormal circadian variations in autonomic function in rats with heart failure. We developed an experimental system that enables continuous 24-48 hour sampling of blood pressure and heart rate in conscious, unrestrained rats. Low frequency components of diastolic blood pressure variability, an index of sympathetic tone, were higher during the awakening period than during the sleeping period. The enhanced sympathetic tone during the awakening period was related to an augmentation of central chemosensitiviy evaluated by hourly intermittent hypercapnic conditions.
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