Development of easy and less invasive diagnostic technique for senile systemic (cardiac) amyloidosis.

• Project/Area Number: 20590820
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IKEDA Shu-ichi Shinshu University, 医学部, 教授 (60135134)
• Co-Investigator(Kenkyū-buntansha): YAZAKI Masahide 信州大学, 医学部附属病院, 講師 (70372513) ; KOYAMA Jun 信州大学, 医学系研究科, 准教授 (10303463)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 老人性アミロイドーシス / 心アミロイドーシス / トランスサイレチン / アミロイド / 皮膚生検 / 腹壁脂肪組織 / ALアミロイド / アミロイドーシス / 手根管症候群

Research Abstract

Senile systemic amyloidosis (SSA) is a main cause of intractable heart failure in the elderly individuals. To make a definitive diagnosis of SSA histological demonstration of amyloid deposition is necessary and endomyocardial biopsy might be most suitable. However, this biopsy cannot be always applicable for the aged patients. During past 3 years 11 patients with SSA (6 males and 5 female ; ages from 70 to 97 years) underwent skin biopsy from abdominal wall and 8 showed amyloid deposition. It is concluded that surgical skin biopsy including deep subcutaneous tissue is useful in demonstrating amyloid deposition in SSA patients.

Research Products

• [Journal Article] Senile systemic amyloidosis in an aged savannah monkey (cercopithecus aethiops) with tenosynovial degeneration. (2010)
  • Author(s): Chambers JK, Kanda T, Shirai A, Higuchi K, Ikeda S, Une Y
  • Journal Title: J Vet Med Sci 72 Pages: 657-659
  • Peer Reviewed
• [Journal Article] Distribution of neprilysin and deposit patterns of Aβ subtypes in the brains of aged squirrel monkeys ( Saimiri sciureus). (2010)
  • Author(s): Chambers JK, Kuribayashi H, Ikeda S, Une Y
  • Journal Title: Amyloid 17 Pages: 75-82
  • Peer Reviewed
• [Journal Article] Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloidangiopathy. (2010)
  • Author(s): Hirohata M, Yoshita M, Ishida C, Ikeda SI, Tamaoka A, Kuzuhara S, Shoji M, Ando Y, Tokuda T, Yamada M
  • Journal Title: Eur J Neurol 17 Pages: 823-829
  • Peer Reviewed
• [Journal Article] Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid olyneuropathy. (2010)
  • Author(s): Tojo K, Tsuchiya-Suzuki A, Sekijima Y, Morita H, Sumita N, Ikeda S
  • Journal Title: Amyloid 17 Pages: 32-35
  • Peer Reviewed
• [Journal Article] Prognostic significance of strain imaging in light-chain amyloidosis (reply to the letter) (2010)
  • Author(s): Koyama J, Falk RH
  • Journal Title: J Am Coll Cardiol Img 3 Pages: 788-788
  • Peer Reviewed
• [Journal Article] Prognostic significance of strain Doppler imaging in patients with light-chain amyloidosis. (2010)
  • Author(s): Koyama J, Falk RH
  • Journal Title: J Am Coll Cardiol Img 3 Pages: 333-342
  • Peer Reviewed
• [Journal Article] Senile Systemic Amyloidosis in an Aged Savannah Monkey(Cercopithecusaethiops)with Tenosynovial Degeneration. (2010)
  • Author(s): Chambers JK, et al
  • Journal Title: J Vet Med Sci Volume: 72 Pages: 657-659
  • Peer Reviewed
• [Journal Article] Distribution of neprilysin and deposit patterns of Aβ subtypes in the brains of aged squirrel monkeys(Saimiri sciureus) (2010)
  • Author(s): Chambers JK, et al
  • Journal Title: Amyloid Volume: 17 Pages: 75-82
  • Peer Reviewed
• [Journal Article] Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy (2010)
  • Author(s): Hirohata M, et al
  • Journal Title: Eur J Neurol Volume: 17 Pages: 823-829
  • Peer Reviewed
• [Journal Article] Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation. (2010)
  • Author(s): Katoh N, et al
  • Journal Title: Muscle Nerve Volume: 41 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy (2010)
  • Author(s): Tojo K, et al
  • Journal Title: Amyloid Volume: 17: Pages: 32-35
  • Peer Reviewed
• [Journal Article] アミロイドーシス (2010)
  • Author(s): 池田修一
  • Journal Title: 内科 Volume: 105 Pages: 1301-1306
• [Journal Article] Significant deposition of wild type transthyretin-derived amyloid in the gastrointestinal tract of aged individuals. (2009)
  • Author(s): Ikeda S, Tojo K, Tsuchiya-Suzuki A, Akamatu T, Hashimoto T, Higuchi K
  • Journal Title: Amyloid 16 Pages: 174-177
  • Peer Reviewed
• [Journal Article] Rituximab therapy in nephrotic syndrome due to AH amyloidosis. (2009)
  • Author(s): Katoh N, Matsuda M, Miyazaki D, Gono T, Yazaki M, Ikeda S
  • Journal Title: Amyloid 16 Pages: 178-180
  • NAID: 120007110405
  • Peer Reviewed
• [Journal Article] Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation. (2009)
  • Author(s): Katoh N, Matsuda M, Yoshida T, Yazaki M, Morita H, Sakashita K, Ikeda S.
  • Journal Title: Muscle Nerve 41 Pages: 138-143
  • Peer Reviewed
• [Journal Article] The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. (2009)
  • Author(s): Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda S, Sobue G
  • Journal Title: Amyloid 16 Pages: 142-148
  • Peer Reviewed
• [Journal Article] Marked shrinkage of amyloid lymphadenopathy after an intensive chemotherapy in a patient with IgM-associated AL amyloidosis. (2009)
  • Author(s): Tazawa K, Katoh N, Shimojima Y, Matsuda M, Ikeda S
  • Journal Title: Amyloid 16 Pages: 183-185
  • Peer Reviewed
• [Journal Article] Slaughtered aged cattle might be one dietary source exhibiting amyloid enhancing factor activity. (2009)
  • Author(s): Yoshida T, Zhang P, Fu X, Higuchi K, Ikeda S
  • Journal Title: Amyloid 16 Pages: 25-31
  • Peer Reviewed
• [Journal Article] Cardiomyopathy in a Japanese family with the Glu61Lys transthyretin variant : a new phenotype. (2009)
  • Author(s): Noto Y, Tokuda T, Shiga K, Tsuchiya A, Yazaki M, Matoba S, Nakagawa M
  • Journal Title: Amyloid 16 Pages: 99-102
  • NAID: 10025625608
  • Peer Reviewed
• [Journal Article] Hereditary rimmed vacuole myopathy showing interstitial amyloid deposition in muscle tissue. (2009)
  • Author(s): Kojima Y, Sakai K, Ishida C, Asaka T, Hamaguchi T, Nozaki I, Fukushima K, Tsuchiya A, Kametani F, Yazaki M, Okino S, Yamada M
  • Journal Title: Muscle Nerve 40 Pages: 472-475
  • Peer Reviewed
• [Journal Article] Early cardiac involvement in senile systemic amyloidosis: a case report. (2009)
  • Author(s): Yamano M, Azuma A, Yazaki M, Ikeda S, Sawada T, Matsubara H.
  • Journal Title: Amyloid 15 Pages: 54-59
  • Peer Reviewed
• [Journal Article] Significant deposition of wild type transthyretin-derived amyloid in the gastrointestinal tract of aged individuals (2009)
  • Author(s): Ikeda S, et al
  • Journal Title: Amyloid 16 Pages: 178-180
  • Peer Reviewed
• [Journal Article] Rituximab therapy in nephrotic syndrome due to AH amyloidosis (2009)
  • Author(s): Katoh N, et al
  • Journal Title: Amyloid 16 Pages: 178-180
  • Peer Reviewed
• [Journal Article] Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation. (2009)
  • Author(s): Katoh N, et al
  • Journal Title: Muscle Nerve 41 Pages: 138-143
  • Peer Reviewed
• [Journal Article] The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy (2009)
  • Author(s): Koike H, et al
  • Journal Title: Amyloid 16 Pages: 142-148
  • Peer Reviewed
• [Journal Article] Marked shrinkage of amyloid lymphadenopathy after an intensive chemotherapy in a patient with IgM-associated AL amyloidosis (2009)
  • Author(s): Tazawa K, et al
  • Journal Title: Amyloid 16 Pages: 183-185
  • Peer Reviewed
• [Journal Article] Slaughtered aged cattle might be one dietary source exhibiting amyloid enhancing factor activity (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Amyloid 16 Pages: 25-31
  • Peer Reviewed
• [Journal Article] Cortical petechial hemorrhage subarachnoid hemorrhage and corticosteroid-responsive leukoencephalopathy in a patient withcerebral amyloid angiopathy. (2008)
  • Author(s): Machida K, Tojo K, Naito K, Gono T, Kusano Y, Ikeda S
  • Journal Title: Amyloid 15 Pages: 60-64
  • Peer Reviewed
• [Journal Article] Nephrotic syndrome due to primary systemic AL amyloidosis, successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone. (2008)
  • Author(s): Matsuda M, Gono T, Katoh N, Yoshida T, Tazawa K, Shimojima Y, Ishii W, Fushimi T, Ikeda S
  • Journal Title: Intern Med 47 Pages: 543-549
  • Peer Reviewed
• [Journal Article] AL amyloidosis manifesting as systemic lymphadenopathy. (2008)
  • Author(s): Matsuda M, Gono T, Shimojima Y, Yoshida T, Katoh N, Hoshii Y, Yamada T, Ikeda S
  • Journal Title: Amyloid 15 Pages: 117-124
  • Peer Reviewed
• [Journal Article] AH amyloidosis associated with an immunoglobulin heavy chain variable region(VHI) fragmen t: A case report. (2008)
  • Author(s): Miyazaki D, Yazaki M, Gono T, Kametani F, Tsuchiya A, Matsuda M, Takenaka Y, Hosii Y, Ikeda S
  • Journal Title: Amyloid 15 Pages: 125-128
  • Peer Reviewed
• [Journal Article] Ten-year follow-up of peripheral nerve function in patients with familial amyloid polyneuropathy after liver transplantation. (2008)
  • Author(s): Shimojima Y, Morita H, Kobayashi S, Takei Y, Ikeda S
  • Journal Title: J Neurol 255 Pages: 1220-1225
  • Peer Reviewed
• [Journal Article] Amyloidogenic transthyretin Val30Met homozygote showing unusually early-onset familial amyloid polyneuropathy. (2008)
  • Author(s): Tojo K, Sekijima Y,Machida K, Tsuchiya A, Yazaki M, Ikeda S
  • Journal Title: Muscle Nerve 37 Pages: 796-803
  • Peer Reviewed
• [Journal Article] Marked regression of abdominal fat amyloid in patients with familial amyloid polyneuropathy during long-term follow-up after liver transplantation. (2008)
  • Author(s): Tsuchiya A, Yazaki M, Kametani F, Takei Y, Ikeda S
  • Journal Title: Liver Transpl 14 Pages: 563-570
  • Peer Reviewed
• [Journal Article] Non-senile wild-type transthyretin systemic amyloidosis presenting as bilateral carpal tunnel syndrome. (2008)
  • Author(s): Kodaira M, Sekijima Y , Tojo K , Tsuchiya A , Yazaki M , Ikeda S, Sekijima Y, Hoshii Y, Tachibana S
  • Journal Title: J Peripher Nerv Syst 13 Pages: 148-150
  • Peer Reviewed
• [Journal Article] Relationship of plasma brain-type natriuretic peptide levels to left ventricular longitudinal function in patients with congestive heart failure assessed by strain Doppler imaging. (2008)
  • Author(s): Yoneyama A, Koyama J, Tomita T, Kumazaki S, Tsutsui H, Watanabe N, Kinoshita O, Ikeda U
  • Journal Title: Int J Cardiol 130 Pages: 56-63
  • Peer Reviewed
• [Journal Article] Cortical petechial hemorrhage subarachnoid hemorrhage and corticosteroid-responsive leukoence phalopathy in a patient with cerebral amyloid angiopathy. (2008)
  • Author(s): Machida K, et al
  • Journal Title: Amyloid 15 Pages: 60-64
  • Peer Reviewed
• [Journal Article] Nephrotic syndrome due to primary systemic AL amyloidosis, successfully treated with VAD (vincristine, doxorubicin and dexamethasone)alone. (2008)
  • Author(s): Matsuda M, et al
  • Journal Title: Intern Med 47 Pages: 543-549
  • Peer Reviewed
• [Journal Article] AL amyloidosis manifesting as systemic lymphadenopathy. (2008)
  • Author(s): Matsuda M, et al
  • Journal Title: Amyloid 15 Pages: 117-124
  • Peer Reviewed
• [Journal Article] AH amyloidosis associated with animaiunoglobulin heavy chain variable region(VHI)fragment : A case report. (2008)
  • Author(s): Miyazaki D, et al
  • Journal Title: Amyloid 15 Pages: 125-128
  • Peer Reviewed
• [Journal Article] Ten-year follow-up of peripheral nerve function in patients with familial amyloid polyneuropathy after liver transplantation. (2008)
  • Author(s): Shimo jima Y, et al
  • Journal Title: J Neurol 255 Pages: 1220-1225
  • Peer Reviewed
• [Journal Article] Amyloidogenic transthyretin Val30Met homozygote showing unusually early-onset familial amyloid polyneuropathy. (2008)
  • Author(s): Tojo K, et al
  • Journal Title: Musele Nerve 37 Pages: 796-803
  • Peer Reviewed
• [Journal Article] Marked regression of abdominal fat amyloid in patients with familial amyloid polyneuropathy during long-term follow-up after liver transplantation. (2008)
  • Author(s): Tsuchiya A, et al
  • Journal Title: Liver Transpl 14 Pages: 563-570
  • Peer Reviewed
• [Journal Article] Non-senile witd-type transthyret in systemic amyloidosis presenting as bilateral carpal tunnel syndrome. (2008)
  • Author(s): Kodaira M, et al
  • Journal Title: J Peripher Nerv Syst 13 Pages: 148-150
  • Peer Reviewed
• [Presentation] 肝移植を受けたFAP患者45例の術後経過の検討 (2010)
  • Author(s): 鈴木彩子, 他
  • Organizer: 第28回日本肝移植研究会
  • Place of Presentation: ANAクラウンプラザホテル(広島県)
  • Year and Date: 2010-07-01
• [Presentation] 肝移植を受けたFAP患者45例の術後経過の検討 (2010)
  • Author(s): 鈴木彩子, 他
  • Organizer: 第28回日本肝移植研究会
  • Place of Presentation: 広島
  • Year and Date: 2010-04-10
• [Presentation] 消化管限局免疫グロブリン由来(原発性AL)アミロイドーシスの臨床病態 (2010)
  • Author(s): 加藤修明, 他
  • Organizer: 第107回日本内科学会総会・講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-10
• [Presentation] 消化管限局免疫グロブリン由来(原発性AL)アミロイドーシスの臨床病態 (2010)
  • Author(s): 加藤修明, 他
  • Organizer: 第107回日本内科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-04-10
• [Presentation] Peak systolic velocity of pulmonary venous flow is closely associated with left ventricular global longitudinal strain, which is a powerful predictor of clinical outcome, in patients with light-chain amyloidosis. (2010)
  • Author(s): Koyama J, et al
  • Organizer: AHA scientific sessions 2010 in Chicago (USA).Circulation.(122:A12412)
  • Place of Presentation: abstract
• [Presentation] Left atrial dysfunction in patients with systemic amyloidosis. (2010)
  • Author(s): Minamisawa M, et al
  • Organizer: The 59th annual scientific session, ACC 2010 Atlanta (USA). J Am Coll Cardiol.(55 (suppl) A36)
  • Place of Presentation: abstract
• [Presentation] Severe left atrial dysfunction in patients with non-symptomatic cardiac amyloidosis. (2010)
  • Author(s): Minamisawa M, et al
  • Organizer: ESC congress
  • Place of Presentation: Stockholm (Sweden).
• [Presentation] 免疫グロブリン関連アミロイドーシスにおける末梢神経障害の臨床生理学的検討 (2009)
  • Author(s): 松田正之, 他
  • Organizer: 第50回 日本神経学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] 血管炎を伴う脳アミロイドアンギオパチー(CAA):ステロイド治療後の病態の検討 (2009)
  • Author(s): 池田修一, 他
  • Organizer: 第50回 日本神経学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] Val30Met TTR型家族性アミロイドポリニューロパチーの末梢神経伝導機能の自然経過 (2009)
  • Author(s): 小平農, 他
  • Organizer: 第50回 日本神経学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] 家族性アミロイドポリニューロパチー(FAP)における野生型TTR関与の臓器間比較 (2009)
  • Author(s): 鈴木彩子, 他
  • Organizer: 第50回 日本神経学会総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] アミロイドーシスの診断と治療-アミロイドの代謝動態を中心に- (2009)
  • Author(s): 池田修一(招待講演)
  • Organizer: 第53回 日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2009-04-23
• [Presentation] 本邦における全身性ALアミロイドーシスの臨床像・当科における160例の臨床的検討 (2009)
  • Author(s): 松田正之, 他
  • Organizer: 第106回日本内科学会総会・講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-12
• [Presentation] 本邦における全身性ALアミロイドーシスの臨床像・当科における160例の臨床的検討 (2009)
  • Author(s): 松田正之, 他
  • Organizer: 第106回 日本内科学会総会・講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-04-12
• [Presentation] 老人性全身性アミロイドーシスの臨床像についての検討 (2009)
  • Author(s): 東城加奈, 他
  • Organizer: 第106回日本内科学会総会・講演会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-11
• [Presentation] 老人性全身性アミロイドーシスの臨床像についての検討 (2009)
  • Author(s): 東城加奈, 他
  • Organizer: 第106回 日本内科学会総会・講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-04-11
• [Presentation] A comparison of ventricular torsion between cardiac amyloidosis and pressure overload hypertrophy caused by aortic valve stenosis. (2009)
  • Author(s): Koyama J, et al
  • Organizer: The 58^<th> annual scientific session, ACC 09(J Am Coll Cardiol.)(53(suppl 1) ; A234)
  • Place of Presentation: Orlando USA).
• [Presentation] 野生型トランスサイレチン由来アミロイドに伴う手根管症候群の臨床像検討 (2008)
  • Author(s): 小平農, 他
  • Organizer: 第49回日本神経学会総
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] The cintribution of wild-type TTR to abdominal fat amyloid in FAP patients : an age-related cange. (2008)
  • Author(s): Tsuchiya-Suzuki A, et al
  • Organizer: The VII th International Symposium on Amyloidosis.
  • Place of Presentation: London(UK).
• [Presentation] TTR-derived amyloid deposition on punched skin biopsy in patients with senile systemic amyloidosis. (2008)
  • Author(s): Ikeda S, et al
  • Organizer: The VII th International Symposium on Amyloidosis.
  • Place of Presentation: London(UK).
• [Presentation] The presence of wild--ype TTR in gastroduodenal mucosal amyloid in FAP patients. (2008)
  • Author(s): Yazaki M, et al
  • Organizer: The VII th International Symposium on Amyloidosis.
  • Place of Presentation: London(UK).
• [Presentation] Elevated plasma BNP levels are associated with global longitudinal left ventricular dysfunction in patients with cardiac amyloidosis. (2008)
  • Author(s): Koyama J, et al
  • Organizer: The 57^<th> annual scientific session, ACC 2008(Am Coll Cardiol.)(51(suppl) ; A 63(abstract).)
  • Place of Presentation: Chicago (USA).
• [Presentation] 野生型トランスサイレチン由来アミロイドに伴う手根管症候群の臨床像検討 (2008)
  • Author(s): 小平農, 他
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: パシフイコ横浜
• [Presentation] Diagnosis and treatment of systemic amyloidosis. (2008)
  • Author(s): 池田修一
  • Organizer: 第31回日本基礎老化学会シンポジウム
  • Place of Presentation: 長野県松本文化会館
• [Presentation] The cintribution of witd-type TTR to abdominal fat amyloid in FAP patients : an age-related cange. (2008)
  • Author(s): Tsuchiya-Suzuki A, et al
  • Organizer: XIIth International Symposium on Amyloidosis
  • Place of Presentation: King's College London, UK
• [Presentation] TTR-derived amyloid deposit ion on punched skin biopsy in patients with senile systemic amyloidosis. (2008)
  • Author(s): Ikeda S, et al
  • Organizer: XIIth International Symposium on Amyloidosis
  • Place of Presentation: King's College London, UK