Development of easy and less invasive diagnostic technique for senile systemic (cardiac) amyloidosis.
| Project/Area Number |
20590820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
IKEDA Shu-ichi Shinshu University, 医学部, 教授 (60135134)
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| Co-Investigator(Kenkyū-buntansha) |
YAZAKI Masahide 信州大学, 医学部附属病院, 講師 (70372513)
KOYAMA Jun 信州大学, 医学系研究科, 准教授 (10303463)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 老人性アミロイドーシス / 心アミロイドーシス / トランスサイレチン / アミロイド / 皮膚生検 / 腹壁脂肪組織 / ALアミロイド / アミロイドーシス / 手根管症候群 |
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| Research Abstract |
Senile systemic amyloidosis (SSA) is a main cause of intractable heart failure in the elderly individuals. To make a definitive diagnosis of SSA histological demonstration of amyloid deposition is necessary and endomyocardial biopsy might be most suitable. However, this biopsy cannot be always applicable for the aged patients. During past 3 years 11 patients with SSA (6 males and 5 female ; ages from 70 to 97 years) underwent skin biopsy from abdominal wall and 8 showed amyloid deposition. It is concluded that surgical skin biopsy including deep subcutaneous tissue is useful in demonstrating amyloid deposition in SSA patients.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy.2009
Author(s)
Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda S, Sobue G
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Journal Title
Amyloid 16
Pages: 142-148
Related Report
Peer Reviewed
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[Journal Article] Hereditary rimmed vacuole myopathy showing interstitial amyloid deposition in muscle tissue.2009
Author(s)
Kojima Y, Sakai K, Ishida C, Asaka T, Hamaguchi T, Nozaki I, Fukushima K, Tsuchiya A, Kametani F, Yazaki M, Okino S, Yamada M
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Journal Title
Muscle Nerve 40
Pages: 472-475
Related Report
Peer Reviewed
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[Journal Article] Nephrotic syndrome due to primary systemic AL amyloidosis, successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone.2008
Author(s)
Matsuda M, Gono T, Katoh N, Yoshida T, Tazawa K, Shimojima Y, Ishii W, Fushimi T, Ikeda S
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Journal Title
Intern Med 47
Pages: 543-549
Related Report
Peer Reviewed
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