Insights into association between autonomic nerve system and immune regulation in patients with chronic heart failure

• Project/Area Number: 20590821
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Shinshu University
• Principal Investigator: IZAWA Atsushi Shinshu University, 医学系研究科, 助教 (50464095)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心臓自律神経機能 / 慢性心不全 / 動脈硬化 / リンパ球 / 免疫制御 / 心不全の病態 / 心不全の治療 / 心臓自律神経 / 心不全と免疫系 / サイトカイン / 調節性T細胞 / Th1 / Th2サイトカイン / 心血管疾患 / 酸化ストレス

Research Abstract

Chronic heart failure is an evolving paradigm, which limits patient's quality of life and long-term survival. In this study, we explored the association between autonomic nerve system and immune system regulating inflammatory response. The importance of iodine-123 Metaiodobenzylguanidine uptake ratio between lung and heart has been demonstrated to predict future clinical outcome in patients with idiopathic dilated cardiomyopathy. In addition, we identified an association between the decrease in regulatory T cell population and significance of atherosclerotic disease.

Research Products

• [Journal Article] 高感度CRPは血管炎症のマーカーとして使用されていますが,血栓症の発生にどのように作用しているのですか (2011)
  • Author(s): 伊澤淳, 池田宇一
  • Journal Title: 血栓と循環 (特集:血栓症に関するQ&A PART6) 19 Pages: 67-70
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A,, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res 90 Pages: 364-372
  • Peer Reviewed
• [Journal Article] Early Intervention With Rosuvastatin Decreases the Lipid Components of the Plaque in Acute Coronary Syndrome (2011)
  • Author(s): Otagiri K, Tsutsui H, Kumazaki S, Miyashita Y, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Koyama J, Ikeda U
  • Journal Title: Circ J 75 Pages: 633-641
  • Peer Reviewed
• [Journal Article] Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U
  • Journal Title: Circulation 123 Pages: 594-614
  • Peer Reviewed
• [Journal Article] Successful Treatment of Cardiac Diffuse Large B-cell Lymphoma: A Report of Two Cases (2011)
  • Author(s): Kumazaki S, Izawa A, Minamisawa M, Ishida F, Sano K, Uehara T, Kasai H, Tomita T, Miyashita Y, Koyama J, Ikeda U
  • Journal Title: Shinshu Med J in press
  • NAID: 130004810200
  • Peer Reviewed
• [Journal Article] Transient Pseudorestrictive Pattern of Transmitral Flow Velocity Curve in Patients with Paroxysmal Atrial Fibrillation. (2011)
  • Author(s): Motoki H, Koyama J, Tomita T, Aizawa K, Kasai H, Koshikawa M, Izawa A, Kumazaki S, Takahashi M, Ikeda U.
  • Journal Title: Echocardiography. Volume: 28 Pages: 289-297
  • Peer Reviewed
• [Journal Article] Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury. (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
  • Journal Title: Circulation. Volume: 123 Pages: 594-604
  • Peer Reviewed
• [Journal Article] Early Intervention With Rosuvastatin Decreases the Lipid Components of the Plaque in Acute Coronary Syndrome. (2011)
  • Author(s): Otagiri K, Tsutsui H, Kumazaki S, Miyashita Y, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Koyama J, Ikeda U.
  • Journal Title: Circ J. Volume: 75 Pages: 633-641
  • Peer Reviewed
• [Journal Article] 高感度CRPは血管炎症のマーカーとして使用されていますが、血栓症の発生にどのように作用しているのですか. (2011)
  • Author(s): 伊澤淳、池田宇一
  • Journal Title: 血栓と循環特集「血栓症に関するQ&APART6」 Volume: 19 Pages: 67-70
• [Journal Article] Dynamic Ieft ventricular outflow tract obstruction due to anemia in a 71-year-old patient with sigmoid septum. (2010)
  • Author(s): Hioki H, Izawa A, Miura T, Motoki H, Aizawa K, Koshikawa M, Kasai H, Tomita T, Miyashita Y, Kumazaki S, Koyama J, Ikeda U.
  • Journal Title: Journal of Cardiology Cases. Volume: 1
  • Peer Reviewed
• [Journal Article] A novel in vivo regulatory role of P-glycoprotein in alloimmunity. (2010)
  • Author(s): Izawa A, Schatton T, Frank NY, Ueno T, Yamaura K, Pendse SS, Margaryan A, Grimm M, Gasser M, Waaga-Gasser AM, Sayegh MH, Frank MH.
  • Journal Title: Biochem Biophys Res Commun. Volume: 394 Pages: 646-652
  • Peer Reviewed
• [Journal Article] A case of left atrial involvement of cardiac sarcoidosis manifesting as atrial flutter treated with corticosteroids. (2010)
  • Author(s): Aso S, Izawa A, Abe N, Motoki H, Kasai H, Tomita T, Kumazaki S, Koyama J, Yazaki Y, Ikeda U.
  • Journal Title: Journal of Cardiology Cases. Volume: 1
  • Peer Reviewed
• [Journal Article] Effect of graft adaptation of the internal mammary artery on longitudinal phasic blood flow velocity characteristics after surgery. (2010)
  • Author(s): Kumazaki S, Koyama J, Aizawa K, Kasai H, Koshikawa M, Izawa A, Tomita T, Takahashi M, Ikeda U.
  • Journal Title: Heart Vessels. Volume: 25 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Acute myocardial infarction in a 16-year-old girl with chronic GVHD. (2010)
  • Author(s): Miura T, Izawa A, Kumazaki S, Ishii E, Otagiri K, Aizawa K, Koshikawa M, Kasai H, Tomita T, Miyashita Y, Tsutsui H, Koyama J, Ikeda U.
  • Journal Title: Bone Marrow Transplant. (On-line)(On-line (Feb 22))
  • Peer Reviewed
• [Journal Article] Elevated osteopontin levels in patients with peripheral arterial disease (2009)
  • Author(s): Koshikawa M, Aizawa K, Kasai H, Izawa A, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Shimodaira S, Takahashi M, Ikeda U
  • Journal Title: Angiolog 60 Pages: 42-45
  • Peer Reviewed
• [Journal Article] Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome. (2009)
  • Author(s): Tomita T, Aizawa K, Shimada K, Motoki H, Otagiri K, Koshikawa M, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: Int J Cardiol([電子ジャーナル])
  • Peer Reviewed
• [Journal Article] Coagulation activity is increased in the left atria of patients with paroxysmal atrial fibrillation during the non-paroxysmal period. (2009)
  • Author(s): Motoki H, Tomita T, Aizawa K, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: fibrillation during the non-paroxysmal period. Comparison with chronic atrial fibro;;ation, Circ J 73 Pages: 1403-1407
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of coronary endothelial function following sirolimus-eluting stent implantation by using positron emission tomography (2009)
  • Author(s): Horigome M, Kumazaki S, Hattori N, Kasai H, Horigome M, Aizawa K, Izawa A, Tomita T, Tsutsui H, Koyama J, Sakurai S, Ikeda U
  • Journal Title: Cradiolongy 114 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Rationale and design of assessment of lipophilic vs. hydrophilic statin therapy in acute myocardial infarction (the ALPS-AMI)study (2009)
  • Author(s): Kashima Y, Izawa A, Aizawa K, Koshikawa M, Kasai H, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Ikeda U
  • Journal Title: J Cardiol 54 Pages: 76-79
  • NAID: 10025184416
  • Peer Reviewed
• [Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases (2009)
  • Author(s): Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U
  • Journal Title: Curr Pharm Des 15 Pages: 2778-2783
  • Peer Reviewed
• [Journal Article] 動脈硬化とバイオマーカー(特集:潜在性動脈硬化症) (2009)
  • Author(s): 伊澤淳, 池田宇一
  • Journal Title: 動脈硬化予防 7 Pages: 53-58
• [Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases. (2009)
  • Author(s): Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U.
  • Journal Title: Curr Pharm Des. 15 Pages: 2778-2783
  • Peer Reviewed
• [Journal Article] Rationale and design of assessment of lipophilic vs. hydrophilic statin therapy in acute myocardial infarction(the ALPS-AMI)study. (2009)
  • Author(s): Kashima Y, Izawa A, Aizawa K, Koshikawa M, Kasai H, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Ikeda U.
  • Journal Title: J Cardiol. 54 Pages: 76-79
  • NAID: 10025184416
  • Peer Reviewed
• [Journal Article] Noninvasive evaluation of coronary endothelial function following sirolimuseluting stent implantation by using positron emission tomography. (2009)
  • Author(s): Horigome M, Kumazaki S, Hattori N, Kasai H, Horigome M, Aizawa K, Izawa A, Tomita T, Tsutsui H, Koyama J, Sakurai S, Ikeda U.
  • Journal Title: Cardiology. 114 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Coagulation activity is increased in the left atria of patients with paroxysmal atrial fibrillation during the non-paroxysmal period. Comparison with chronic atrial fibrillation. (2009)
  • Author(s): Motoki H, Tomita T, Aizawa K, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U.
  • Journal Title: Circ J. 73 Pages: 1403-1407
  • NAID: 10025933409
  • Peer Reviewed
• [Journal Article] Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome. (2009)
  • Author(s): Tomita T, Aizawa K, Shimada K, Motoki H, Otagiri K, Koshikawa M, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U.
  • Journal Title: Int J Cardiol. (On-line)(On-line (May 11))
  • Peer Reviewed
• [Journal Article] Elevated osteopontin levels in patients with peripheral arterial disease. (2009)
  • Author(s): Koshikawa M, Aizawa K, Kasai H, Izawa A, Tomita T, Kumazaki S, Tsutsui H, Koyama J, Shimodaira S, Takahashi M, Ikeda U.
  • Journal Title: Angiology 60 Pages: 42-45
  • Peer Reviewed
• [Journal Article] M, Higuchi M, Koh CS, Yamamoto K, Immunoadsorption therapy for patients with dilated cardiomyopathy and heart failure (2008)
  • Author(s): Ikeda U, Kasai H, Izawa A, Koyama J, Yazaki Y, Takahashi M, Higuchi M, Koh CS, Yamamoto K
  • Journal Title: Curr Cardiol Rev 4 Pages: 219-222
  • Peer Reviewed
• [Journal Article] Risk stratification assessed by combined lung and heart iodine-123 metaiodobenzylguanidine uptake in patients with idiopathic dilated cardiomyopathy (2008)
  • Author(s): Kamiyoshi Y, Yazaki Y, Urushibata K, Koizumu T, Kasai H, Izawa A, Kinoshita O, Hongo M, Ikeda U
  • Journal Title: Am J Cardiol 101 Pages: 1482-1486
  • Peer Reviewed
• [Journal Article] 心筋細胞障害により拡大した心臓を小さくするためにどのような薬物療法を行うのでしょうか (2008)
  • Author(s): 伊澤淳
  • Journal Title: 薬局(特集:心不全) 59 Pages: 38-42
• [Journal Article] Risk stratification assessed by combined lung and heartiodine-123 metaiodobenzylguanidine uptake in patients with idiopathic dilated cardiomyopathy. (2008)
  • Author(s): Kamiyoshi Y, Yazaki Y, Urushibata K, Koizumu T, Kasai H, Izawa A, Kinoshita O, Hongo M, Ikeda U.
  • Journal Title: American Journal of Cardiology 101 Pages: 1482-1486
  • Peer Reviewed
• [Presentation] 慢性腎臓病は末梢動脈疾患の危険因子である. (2010)
  • Author(s): 山崎佐枝子、越川めぐみ、相澤万象、笠井宏樹、伊澤淳、富田威、熊崎節央、小山潤、池田宇一
  • Organizer: 第51回日本脈管学会総会
  • Place of Presentation: 旭川
  • Year and Date: 2010-10-14
• [Presentation] Chronic Kidney Disease is a Risk Factor for Peripheral Arterial Disease (2010)
  • Author(s): Yamasaki S, Koshikawa M, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Koyama J, Ikeda U.
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-07-15
• [Presentation] 難治性血管炎に対する血管新生療法 (2010)
  • Author(s): 伊澤淳, 越川めぐみ、池田宇一
  • Organizer: 第38回日本血管外科学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 2010-05-22
• [Presentation] 胸腹部大動脈瘤患者における虚血性心疾患の合併およびその予測因子に関する検討 (2010)
  • Author(s): 三枝達也、伊澤淳、池田宇一, 他
  • Organizer: 第107回日本内科学会総会・講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-09
• [Presentation] Immunoadsorption therapy may improve cardiac sympathetic nerve activity in patients with dilated cardiomyopathy. (2010)
  • Author(s): Kasai H, Izawa A, Kashima Y, Aizawa K, Koshikawa M, Miyashita Y, Kumazaki S, Tomita T, Koyama J, Yazaki Y, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Peak systolic velocity of pulmonary venous flow is closely associated with left ventricular global longitudinal speckle strain in patients with cardiomyopathy. (2010)
  • Author(s): Koyama J, Motoki H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U
  • Organizer: AHA scientific sessions
  • Place of Presentation: シカゴ, 米国
• [Presentation] Torsion Analysis in the Early Detection of Anthracycline Mediated Cardiomyopathy. (2010)
  • Author(s): Motoki H, Koyama J, Aso S, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
• [Presentation] Critical Role of Hyaluronan Derived From Vascular Smooth Muscle Cells in Neointimal Formation After Vascular Injury. (2010)
  • Author(s): Takahashi M, Hata T, Kawaguchi K, Izawa A, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
• [Presentation] Therapeutic Angiogenesis for Patients with Ischemic Vasculitis by Autologous Mononuclear Cell Implantation. (2010)
  • Author(s): Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Minota S, Horie T, Aizawa Y, Amano J, Murohara T, Matsubara H, Takahashi M, Ikeda U
  • Organizer: AHA scientific sessions 2010
  • Place of Presentation: シカゴ, 米国
• [Presentation] 拡張型心筋症に対する免疫吸着療法における酸化ストレスへの急性期効果 (2010)
  • Author(s): 笠井宏樹, 伊澤淳, 嘉嶋勇一郎, 小山潤, 矢崎善一, 池田宇一
  • Organizer: 第14回日本心不全が学会
  • Place of Presentation: 東京
• [Presentation] Immunoadsorption therapy may improve cardiac sympathetic nerve activity in patients with dilated cardiomyopathy (2010)
  • Author(s): Kasai H, Izawa A, Kashima Y, Aizawa K, Koshikawa M, Miyashita Y, Kumazaki S, Tomita T, Koyama J, Yazaki Y, Ikeda U
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Improvement of longitudinal left ventricular function is associated with left atrial strain enhancement early after pulmonary-veinisolation for atrial fibrillation. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Effect of atrial fibrillation on left ventricular longitudinal function: serial observation by speckle tracking echocardiography. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Acute effect of pulmonary-vein isolation for atrial fibrillation on longitudinal left ventricular function and stroke volume. (2010)
  • Author(s): Koyama J, Motoki H, Yoneyama A, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Critical role of hyaluronan derived from vascular smooth muscle cells in neointimal formation after vascular injury. (2010)
  • Author(s): Kashima Y, Takahashi M, Hata T, Kawaguchi M, Izawa A, Itano N, Taniguchi S, Ikeda U
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Contribution of CD4+-Th17 cells to angiogenesis fllowing hindlimb ischemia in mice. (2010)
  • Author(s): Hata T, Takahashi M, Kawaguchi M, Kashima Y, Hida S, Izawa A, Taki S, Iwakura Y, Ikeda U.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都
• [Presentation] Haemodynamic effect and the potential role in oxidative stresss of immuneoadsorption therapy for cardiomyopathy (2009)
  • Author(s): 笠井宏樹, 伊澤淳, 他9名
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] 重症慢性心不全に対する免疫吸着療法-酸化ストレスとの関連 (2009)
  • Author(s): 笠井宏樹, 嘉嶋勇一郎, 元木博彦,伊澤淳, 小山潤, 上條祐司, 樋口誠, 矢崎善一, 池田宇一
  • Organizer: 第30回日本アフェレシス学会
  • Place of Presentation: 札幌
• [Presentation] Role of interleukin-6 and its crosstalk with AT1R in acute and chronic rejection of murine cardiac allografts, Circulation, 118, Suppl II: S1015, 2008 (2008)
  • Author(s): Izawa A, Takahashi M, Ise H, Morimoto H, Yajima N, Tagawa Y, Iwakura Y, Ikeda U.
  • Organizer: American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
• [Presentation] Sekiguchi M. Influence of recent advances in the management of heart failure and ventricular arrhythmias on survival in patients with cardiac sarcoidosis.Circulation, 118, Suppl II (2008)
  • Author(s): Yazaki Y, Horigome M, Aizawa K, Tomita T, Kasai H, Izawa A, Hongo M, Ikeda U
  • Organizer: S1033, 2008, American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
• [Presentation] Transient pseudorestrictive pattern of transmitral Doppler flow pattern in patients with paroxysmal atrial fibrillation, Circulation, 118, Suppl II: (2008)
  • Author(s): Motoki H, Koyama J, Tomita T, Aizawa K, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Ikeda U
  • Organizer: S603, 2008, American Heart Association
  • Place of Presentation: ニューオリンズ, 米国
• [Book] 心筋梗塞の再発予防.循環器疾患最新の治療 (2011)
  • Author(s): 伊澤淳, 池田宇一
  • Publisher: 南江堂
• [Book] 病気と薬パーフェクトブック2011(分担執筆) (2011)
  • Author(s): 横田千津子、池田宇一, 他編集
  • Total Pages: 1891
  • Publisher: 南山堂
• [Book] 実験医学増刊「血管研究と血管治療」(分担執筆) (2011)
  • Author(s): 高倉信幸、尾池雄一, 他編集
  • Total Pages: 226
  • Publisher: 羊土社
• [Book] 実験医学2010(Buerger病および膠原病に合併する虚血肢を対象とした血管再生療法) (2010)
  • Publisher: 羊土社
• [Book] 脱水 浮腫 病気と薬パーフェクトBOOK 2010,薬局増刊号 (2010)
  • Author(s): 伊澤淳
  • Publisher: 南山堂
• [Book] 病気と薬パーフェクトブック2010 (2010)
  • Author(s): 横田千津子、池田宇一, 他編集
  • Total Pages: 1787
  • Publisher: 南山堂
• [Book] ワシントンマニュアル 循環器内科アップグレード (2010)
  • Author(s): 池田宇一 監訳
  • Total Pages: 452
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 循環器疾患最新の治療2010-2011 (2010)
  • Author(s): 伊澤淳、池田宇一(分担執筆)
  • Total Pages: 567
  • Publisher: 南江堂
• [Book] コレステロールと末梢動脈硬化 コレステロール-基礎から臨床ヘ- (2009)
  • Author(s): 伊澤淳, 池田宇一
  • Publisher: ライフサイエンス出版
• [Book] 心不全エッセンシャルがガイド--治療方針とエビデンス-- (2009)
  • Author(s): 池田宇一監訳
  • Total Pages: 579
  • Publisher: メディカル・サイエンス・インターナショナル