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Development of a Novel Therapeutic Strategy for Cardiovascular Disease With Use of Accelerating Bed

Research Project

Project/Area Number 20590824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

FUJITA Masatoshi  Kyoto University, 大学院・医学研究科, 教授 (50190046)

Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Tetsuya  滋賀医科大学, 医学部, 講師 (70273406)
MIYAMOTO Shoichi  (財)田附興風会, 心臓センター, 副部長 (30435557)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords加速ベッド / 動脈硬化 / 狭心症 / 糖尿病 / 血管内皮機能 / 運動耐容能 / 血管内皮前駆細胞 / Endo-PAT / 心不全 / 心筋シンチグラフィ / トレッドミル負荷試験
Research Abstract

The whole-body periodic acceleration (WBPA) bed has recently been developed as a "passive exercise" device by providing increased pulsatile shear stress for improvement of vascular endothelial function. In the present study, we evaluated the effects of the WBPA treatment on exercise tolerance in patients with chronic stable angina, coronary flow reserve in healthy subjects and patients with coronary artery disease, and vascular endothelial function in type 2 diabetic patients. In angina patients, 20 sessions of the WBPA treatment improved the treadmill exercise tolerance, myocardial perfusion at rest and during adenosine infusion, and left ventricular remodeling. Only one session of the WBPA treatment ameliorated coronary flow reserve in patients with coronary artery disease as well as in normal subjects. In type 2 diabetic patients, the impaired vascular endothelial function was augmented by 10 sessions of the WBPA treatment, and the improvement was associated with the increase in the number of endothelial progenitor cells. These promising results of the WBPA treatment provide a possibility that the treatment will be a novel therapeutic strategy for a variety of cardiovascular diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (16 results)

  • [Journal Article] Effect on treadmill exercise capacity,myocardial ischemia, and left ventricular function as a result of repeated whole-body periodicacceleration with heparin pretreatment in patients with angina pectoris and mild left ventricular dysfunction.2011

    • Author(s)
      Miyamoto S, Fujita M, Inoko M, Oba M,Hosokawa R, Haruna T, Izumi T, Saji Y,Nakane E, Abe T, Ueyama K, Nohara R
    • Journal Title

      The American Journal of Cardiology 107(2)

      Pages: 168-174

    • URL

      http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/134603/1/j.amjcard.2010.09.007.pdf

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect on treadmill exercise capacity, myocardial ischemia, and left ventricular function as a result of repeated whole-body periodic acceleration with heparin pretreatment in patients with angina pectoris and mild left ventricular dysfunction.2011

    • Author(s)
      Miyamoto S, Fujita M, et al.
    • Journal Title

      The American Journal of Cardiology

      Volume: 107 Pages: 168-174

    • NAID

      120002723157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Passive exercise using whole body periodic acceleration : effects on coronary microcirculation.2010

    • Author(s)
      Fukuda S, Shimada K, Kawasaki T, Kono Y, Jissho S, Taguchi H, Maeda K, Yoshiyama M, Fujita M, Yoshikawa J
    • Journal Title

      American Heart Journal 159(4)

      Pages: 620-626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] "Passive exercise" using whole body periodic acceleration : effects on coronary microcirculation.2010

    • Author(s)
      Fukuda S, Fujita M, et al.
    • Journal Title

      American Heart Journal

      Volume: 159 Pages: 620-626

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心不全の病態,治療の新たな展望.2009

    • Author(s)
      藤田正俊
    • Journal Title

      Osaka Heart Club 32(8)

      Pages: 9-10

    • Related Report
      2010 Final Research Report
  • [Journal Article] 心不全の病態, 治療の新たな展望2009

    • Author(s)
      藤田正俊
    • Journal Title

      Osaka Heart Club 32(8)

      Pages: 9-10

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Whole-body periodic acceleration enhances brachial endothelial function.2008

    • Author(s)
      Matsumoto T, Fujita M, Tarutani Y, Yamane T, Takashima H, Nakae I, Horie M
    • Journal Title

      Circulation Journal 72(1)

      Pages: 139-143

    • NAID

      110006533929

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body periodic accleration enhances brachial endothelial function.2008

    • Author(s)
      Matsumoto T, Fujita M, et al.
    • Journal Title

      Circulation Journal 72(1)

      Pages: 139-143

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Acute effect of whole-body periodic acceleration on brachial flow-mediated vasodilation assessed by a novel semi-automatic vessel chasing system of UNEXEF18G.2010

    • Author(s)
      Takase B, Nagata M, Fujita M
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      Shanghai
    • Year and Date
      2010-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Acute effects of whole-body periodic acceleration on coronary microcirculation and insulin resistance in type 2 diabetic patients.2010

    • Author(s)
      Fukuda S, Shimada K, Fujita M, Yoshiyama M, Yoshikawa J
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      Shanghai
    • Year and Date
      2010-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Whole-body periodic acceleration with a horizontal motion platform ameliorates exercise tolerance through peripheral effects in chronic heart failure patients and old myocardial infarction.2010

    • Author(s)
      Miyamoto S, Inoko M, Haruna T, Oba M, Saji Y, Nakane E, Abe T, Sasaki K, Itoh H, Fukuda T, Nakashima J, Tanaka N, Ueyama K, Nohara R, Fujita M
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      Shanghai
    • Year and Date
      2010-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Whole-body periodic acceleration mobilizes CD34+/KDR+ cells in type 2 diabetic patients. BIT's 2nd Annual2010

    • Author(s)
      Takahashi Y, Fukuda S, Shimada K, Fujita M
    • Organizer
      International Congress of Cardiology-2010
    • Place of Presentation
      Shanghai
    • Year and Date
      2010-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Acute effect of whole-body periodic acceleration on brachial flow-mediated vasodilation assessed by a novel semi-automatic vessel chasing system of UNEXEF18G2010

    • Author(s)
      Takase B, Fujita M, et al.
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      上海(中国)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acute effects of whole-body periodic acceleration on coronary microcirculation and insulin resistance in type 2 diabetic patients.2010

    • Author(s)
      Fukuda S, Fujita M, et al.
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      上海(中国)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Whole-body periodic acceleration with a horizontal motion platform ameliorates exercise tolerance through peripheral effects in chronic heart failure patients and old myocardial infarction.2010

    • Author(s)
      Miyamoto S, Fujita M, et al.
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      上海(中国)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Whole-body periodic acceleration mobilizes CD34^+/KDR^+ cells in type 2 diabetic patients.2010

    • Author(s)
      Takahashi Y, Fujita M, et al.
    • Organizer
      BIT's 2nd Annual International Congress of Cardiology-2010
    • Place of Presentation
      上海(中国)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Treatment with whole body periodic acceleration with a horizontal motion platform reverses left ventricular remodeling in patients with old myocardial infarction.2010

    • Author(s)
      Miyamoto S, Inoko M, Haruna T, Oba M, Saji Y, Nakane E, Abe T, Sasaki K, Itoh H, Fukuda T, Nakashima J, Tanaka N, Ueyama K, Nohara R, Fujita M
    • Organizer
      The 59th Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      Atlanta
    • Year and Date
      2010-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Whole body periodic acceleration improves coronary microcirculation in healthy subjects and patients with coronary artery disease.2010

    • Author(s)
      Fukuda S, Shimada K, Kawasaki T, Kono Y, Jisso S, Taguchi H, Maeda K, Yoshiyama M, Fujita M, Yoshikawa J
    • Organizer
      The 59th Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      Atlanta
    • Year and Date
      2010-03-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Treatment with whole body periodic acceleration with a horizontal motion platform reverses left ventricular remodeling in patients with old myocardial infarction.2010

    • Author(s)
      Miyamoto S, Fujita M, et al.
    • Organizer
      The 59th Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      米国・アトランタ
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Whole body periodic acceleration improves coronary microcirculation in healthy subjects and patients with coronary artery disease.2010

    • Author(s)
      Fukuda S, Fujita M, et al.
    • Organizer
      The 59th Annual Scientific Session of the American College of Cardiology
    • Place of Presentation
      米国・アトランタ
    • Year and Date
      2010-03-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Noveltreatment with whole body periodic acceleration with a horizontal motion platform improves exercise capacity2009

    • Author(s)
      Miyamoto S, Inoko M, Haruna T, Oba M, Uehara K, Nakae E, Abe T, Sakaki K, Itoh H, Fukuda T, Nakashima J, Tanaka N, Ueyama K, Nohara R, Fujita M
    • Organizer
      myocardial ischemia and left ventricular function in intractable angina patients. European Society of Cardiology Congress
    • Place of Presentation
      Barcelona
    • Year and Date
      2009-08-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel treatment with whole body periodic acceleration with a horizontal motion platform improves exercise capacity, myocardial ischemia and left ventricular function in intractable angina patients.2009

    • Author(s)
      Miyamoto S, Fujita M, et al.
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      スペイン・バルセロナ
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel treatment with periodic acceleration with a horizontal motion platform for anginal patients.2008

    • Author(s)
      Miyamoto S, Fujita M, Nohara R, Hosokawa R, Inoko N, Nagai K, Nakane E, Oba M, Ueyama K, Uehara K
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Munich
    • Year and Date
      2008-08-31
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel treatment with periodic accleration with a horizontal motion platform for anginal patients.2008

    • Author(s)
      Miyamoto S, Fujita M, et al.
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      ドイツ・ミュンヘン
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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