Role of endothelial lipase in serum HDL cholesterol level and life style
| Project/Area Number |
20590825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
ISHIKAWA Yuichi Kobe University, 大学院・保健学研究科, 名誉教授 (90159707)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Kenーichi 神戸大学, 大学院・医学研究科, 教授 (20283880)
ISHIDA Tatsuro 神戸大学, 医学部附属病院, 准教授 (00379413)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂質代謝 / 高比重リポ蛋白 / 血管内皮リパーゼ / 動脈硬化 / 生活習慣病 / 循環器 / 臨床 / 生活翌慣病 / 血管内皮 / リパーゼ / 臨床検査 |
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| Research Abstract |
High-density lipoprotein cholesterol (HDL-C) is a negative risk factor for atherosclerosis. Endothelial lipase (EL) is a regulator of plasma HDL levels. This study was undertaken to clarify the role of EL in serum HDL-C level and life style. Serum EL protein levels were inversely correlated with serum HDL-C levels. Pitavastatin decreased EL levels and increased HDL levels. Serum EL activity was inversely correlated with serum HDL-C levels, and higher in patients with coronary artery disease compared to control subjects. In animal models of low HDL levels, inhibition of EL resulted in a raise in plasma HDL-C levels. Thus, EL is a determinant of plasma HDL levels in humans, and EL inhibition would be useful for HDL-raising therapy.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction.2010
Author(s)
Inoue M, Ishida T, Yasuda T, Toh R, Hara T, Cangara HM, Rikitake Y, Taira K, Sun L, Kundu RK, Quertermous T, Hirata K
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Journal Title
Microvasc Res. 80(2)
Pages: 179-187
NAID
Related Report
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[Journal Article] Pitavastatin decreases expression of endothelial lipase both in vitro and in vivo.2010
Author(s)
Kojima Y, Ishida T, Sun L, Yasuda T, Toh T, Rikitake Y, Fukuda A, Kume N, Koshiyama H, Taniguchi A, Hirata K
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Journal Title
Cardiovasc Res 87(2)
Pages: 385-393
Related Report
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[Journal Article]2010
Author(s)
石田達郎
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Journal Title
Annual Review糖尿病・代謝・内分泌2010(中外医学社)
Pages: 152-169
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