| Project/Area Number |
20590830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TSURUDA Toshihiro University of Miyazaki, 医学部, 助教 (10389570)
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| Co-Investigator(Kenkyū-buntansha) |
ASADA Yujiro 宮崎大学, 医学部, 教授 (70202588)
HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735)
KITAMURA Kazuo 宮崎大学, 医学部, 教授 (50204912)
KATO Johji 宮崎大学, フロンティア学実験総合センター, 教授 (20274780)
ONITSUKA Toshio 宮崎大学, 医学部, 教授 (60108595)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 臨床心血管病態学 / 外膜 / 炎症 / 細胞外基質 / サイトカイン / ケモカイン / マクロファージ / T-リンパ球 / マスト細胞 / メタロプロテアーゼ / 新生血管 / 動脈瘤 / マスト細胞膜安定化剤 |
|---|
| Research Abstract |
Main purpose of the research was aimed at better understanding the pathophysiology of abdominal aortic aneurysm (AAA), and at pursuing a potential medical therapy for the disorder. We specifically focused on the adventitial layer on the pathogenesis. The number of "mast cells" was found to increase in the outer media or adventitia of human AAA. Aneurysmal dilatation of the aorta was seen in the control rats following peri-aortic application of calcium chloride (CaCl_2) treatment, but not in the mast cell-deficient rats. The tranilast, an inhibitor of mast cell degranulation, attenuated AAA development in the rodent models. In the cell culture experiment, a mast cell directly augmented MMP-9 activity. These data suggest that adventitial mast cells play a critical role in the progression of AAA. In addition, inhibition of mast cell activity might be a potential therapeutic target for attenuating the development/progression of AAA.
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