Screening for sleep disordered breathing by cyclic variation of heart rate

• Project/Area Number: 20590832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya City University
• Principal Investigator: HAYANO Junichiro Nagoya City University, 大学院・医学研究科, 教授 (90173054)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 臨床心血管病態学 / 睡眠呼吸障害 / 睡眠時無呼吸 / 心電図 / 心拍変動 / 睡眠時無呼吸症候群 / 心拍数 / 心筋梗塞 / 予後予測 / コンピュータ / 生体信号処理

Research Abstract

Episodes of sleep apnea/hypopnea are associated with characteristic cyclic variation of heart rate (CVHR). We developed automated CVHR-detection algorithm named autocorrelated wave detection with adaptive threshold (ACAT). In 862 subjects referred to diagnostic polysomnography, the ACAT detected patients with moderate-to-severe sleep apnea with 83% sensitivity and 88% specificity.

Research Products

• [Journal Article] Acupuncture to Danzhong but not to Zhongting increases the cardiac vagal component of heart rate variability. (2011)
  • Author(s): Kurono Y, Minagawa M, Ishigami T, Yamada A, Kakamu T, Hayano J.
  • Journal Title: Auton Neurosci. 161 Pages: 116-20
  • Peer Reviewed
• [Journal Article] Cardiovascular tolerance and autonomic nervous responses in unsedated upper gastrointestinal small-caliber endoscopy : a comparison between transnasal and peroral procedures with newly developed mouthpiece. (2011)
  • Author(s): Kataoka H, Hayano J, Mizushima T, Tanaka M, Kubota E, Shimura T, Mizoshita T, Tanida S, Kamiya T, Nojiri S, Mukai S, Mizuno K, Joh T.
  • Journal Title: Dig Endosc. 23 Pages: 78-85
  • NAID: 10028188427
  • Peer Reviewed
• [Journal Article] Screening for obstructive sleep apnea by cyclic variation of heart rate. (2011)
  • Author(s): Hayano J, Watanabe E, Saito Y, Sasaki F, Fujimoto K, Nomiyama T, Kawai K, Kodama I, Sakakibara H.
  • Journal Title: Circ Arrhythm Electrophysiol. 4 Pages: 64-72
  • Peer Reviewed
• [Journal Article] Screening for obstructive sleep apnea by cyclic variation of heart rate (2011)
  • Author(s): 早野順一郎, 他8名
  • Journal Title: Circulation : Arrhythmia and Electrophysiology Volume: 4 Pages: 64-72
  • Peer Reviewed
• [Journal Article] Cardiovascular tolerance and autonomic nervous responses in unsedated upper gastrointestinal small-caliber endoscopy : a comparison between transnasal and peroral procedures with newly developed mouthpiece (2011)
  • Author(s): 片岡洋望、早野順一郎, 他11名
  • Journal Title: Digestive Endoscopy Volume: 23 Pages: 78-85
  • NAID: 10028188427
  • Peer Reviewed
• [Journal Article] Depression, alexithymia and long-term mortality in chronic hemodialysis patients (2011)
  • Author(s): 小嶋雅代、早野順一郎, 他7名
  • Journal Title: Psychotherapy and Psychosomatics Volume: 79 Pages: 303-311
  • Peer Reviewed
• [Journal Article] Depression, alexithymia and long-term mortality in chronic hemodialysis patients. (2010)
  • Author(s): Kojima M, Hayano J, Suzuki S, Seno H, Kasuga H, Takahashi H, Toriyama T, Kawahara H, Furukawa TA.
  • Journal Title: Psychother Psychosom. 79 Pages: 303-311
  • Peer Reviewed
• [Journal Article] Nighttime heart rate and survival in depressed patients post acute myocardial infarction. (2008)
  • Author(s): Carney RM, Steinmeyer B, Freedland KE, Blumenthal JA, Stein PK, Steinhoff WA, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Domitrovich PP, Burg MM, Hayano J, Jaffe AS.
  • Journal Title: Psychosom Med. 70 Pages: 757-763
  • Peer Reviewed
• [Journal Article] Impact of real-world stress on cardiorespiratory resting function during sleep in daily life. (2008)
  • Author(s): Sakakibara M, Kanematsu T, Yasuma F, Hayano J.
  • Journal Title: Psychophysiology. 45 Pages: 667-670
  • Peer Reviewed
• [Journal Article] Loss of fractal heart rate dynamics in depressive hemodialysis patients. (2008)
  • Author(s): Kojima M, Hayano J, Fukuta H, Sakata S, Mukai S, Ohte N, Seno H, Toriyama T, Kawahara H, Furukawa TA, Tokudome S.
  • Journal Title: Psychosom Med. 70 Pages: 177-185
  • Peer Reviewed
• [Journal Article] Non-Gaussian heart rate as an independent predictor of mortality in patients with chronic heart failure. (2008)
  • Author(s): Kiyono K, Hayano J, Watanabe E, Struzik ZR, Yamamoto Y.
  • Journal Title: Heart Rhythm. 5 Pages: 261-268
  • Peer Reviewed
• [Presentation] Cost-Effective Screening for Obstructive Sleep Apnea by Automated ECG Detection of Cyclic Variation of Heart Rate. (2010)
  • Author(s): Junichiro Hayano, Eiichi Watanabe, Yuji Saito, Fumihiko Sasaki, Keisaku Fujimoto, Tetsuo Nomiyama, Kiyohiro Kawai, Itsuo Kodama, Hiroki Sakakibara
  • Organizer: American Heart Association Scientific Session 2010
  • Place of Presentation: 米国シカゴ市
  • Year and Date: 2010-11-13
• [Presentation] Cost-effective screening for obstructive sleep apnea by automated ECG detection of cyclic variation of heart rate (2010)
  • Author(s): 早野順一郎, 他8名
  • Organizer: American Heart Association Scientific Session 2010
  • Place of Presentation: Chicago(McCormick Place)米国
  • Year and Date: 2010-11-13
• [Book] 睡眠時無呼吸症候群 : 循環器科医必須知識 (2008)
  • Author(s): 早野順一郎
  • Publisher: メディカルレビュー社
• [Patent(Industrial Property Rights)] 睡眠時無呼吸診断装置 (2011)
  • Inventor(s): 早野順一郎, 他3名
  • Industrial Property Rights Holder: 早野順一郎(株)デンソー
  • Acquisition Date: 2011-03-04
• [Patent(Industrial Property Rights)] 睡眠呼吸障害の無呼吸発作又は低呼吸発作に伴うCVHRの検出装置 (2010)
  • Inventor(s): 早野順一郎
  • Industrial Property Rights Holder: 名古屋市立大学(株)スズケン
  • Industrial Property Number: 2010-051387
  • Filing Date: 2010-08-26
• [Patent(Industrial Property Rights)] 睡眠呼吸障害の無呼吸発作又は低呼吸発作に伴うCVHRの検出装置 (2008)
  • Inventor(s): 早野順一郎
  • Industrial Property Rights Holder: 名古屋市立大学、(株)スズケン
  • Filing Date: 2008-08-26
• [Patent(Industrial Property Rights)] 血管内皮機能検査装置 (2008)
  • Inventor(s): 早野順一郎、小椋敏彦
  • Industrial Property Rights Holder: オムロンヘルスケア(株)、早野順一郎
  • Acquisition Date: 2008-09-19
• [Patent(Industrial Property Rights)] 睡眠呼吸障害の無呼吸発作又は低呼吸発作に伴うCVHRの検出装置 (2008)
  • Inventor(s): 早野順一郎
  • Industrial Property Rights Holder: 名古屋市立大学早野順一郎株)スズケン
  • Filing Date: 2008-08-26
• [Patent(Industrial Property Rights)] 心電図に基づく発作性心房細動の検出評価システム (2006)
  • Inventor(s): 早野順一郎
  • Industrial Property Rights Holder: 早野順一郎
  • Acquisition Date: 2006-05-19