Predictors for onset of acute myocardial infarction and cerebral infarction using biomarkers and imaging modalities

• Project/Area Number: 20590833
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka City University
• Principal Investigator: EHARA Shoichi Osaka City University, 大学院・医学研究科, 講師 (90382150)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 酸化LDL / ミエロペルオキシダーゼ / パラオキソナーゼ / プラーク / マルチスライスCT / 頸動脈エコー / MRI / 急性冠症候群 / 急性心筋梗塞

Research Abstract

Acute myocardial infarction (AMI) and cerebral infarction (CI) are the leading causes of death in the individuals with atherosclerotic risk factors. As AMI or CI frequently occurs as the first symptom, screening of the patients with unstable plaque is important for prevention of the onset of AMI or CI. We suggested that combined assessment of biomarkers and cardiovascular imaging may be useful for screening patients with unstable plaques.

Research Products

• [Journal Article] Elevated levels of neopterin are associated with carotid plaques with complex morphology in patients with stable angina pectoris. (2010)
  • Author(s): Sugioka K, Naruko T, Hozumi T, Nakagawa M, Kitabayashi C, Ikura Y, Shirai N, Matsumura Y, Ehara S, Ujino K, Itoh A, Haze K, Becker AE, Yoshiyama M, Ueda M
  • Journal Title: Atherosclerosis 208 Pages: 524-530
  • Peer Reviewed
• [Journal Article] 血管石灰化の臨床的画像診断と定量的評価法 (2010)
  • Author(s): 江原省一、葭山稔
  • Journal Title: Clinical Calcium. Vol.20. No.11 Pages: 84-90
• [Journal Article] MDCTによるプラークの評価 (2010)
  • Author(s): 江原省一、葭山稔
  • Journal Title: Heart View. Vol.14. No.7 Pages: 80-87
• [Journal Article] MDCTによるプラークの評価 (2010)
  • Author(s): 江原省一、葭山稔
  • Journal Title: Heart View Volume: 14 Pages: 80-87
• [Journal Article] Comprehensive evaluation of the apex beat using 64-slice computed tomography : Impact of left ventricular mass and distance to chest wall (2010)
  • Author(s): Ehara S, et al
  • Journal Title: J Cardiol Volume: 55 Pages: 256-265
  • NAID: 10027052283
  • Peer Reviewed
• [Journal Article] 血管石灰化の臨床的画像診断と定量的評価法 (2010)
  • Author(s): 江原省一、葭山稔
  • Journal Title: Heart Vessels Volume: 20 Pages: 84-90
• [Journal Article] Inadequate increase in the volume of major epicardial coronary arteries compared with that in left ventricular mass. Novel concept for characterization of coronary arteries using 64-slice computed tomography. (2009)
  • Author(s): Ehara S, Okuyama T, Shirai N, Sugioka K, Oe H, Itoh T, Matsuoka T, Ikura Y, Ueda M, Naruko T, Hozumi T, Yoshiyama M.
  • Journal Title: Circ J. 73 Pages: 1448-1453
  • NAID: 10025933621
  • Peer Reviewed
• [Journal Article] Enhanced expression of haemoglobin scavenger receptor in accumulated macrophages of culprit lesions in acute coronary syndromes. (2009)
  • Author(s): Yunoki K, Naruko T, Komatsu R, Ehara S, Shirai N, Sugioka K, Nakagawa M, Kitabayashi C, Ikura Y, Itoh A, Kusano K, Ohe T, Haze K, Becker AE, Ueda M
  • Journal Title: Eur Heart J. 30 Pages: 1844-1852
  • Peer Reviewed
• [Journal Article] Comparison of determinations of left atrial volume by the biplane area-length and Simpson's methods using 64-slice computed tomography. (2009)
  • Author(s): Takagi Y, Ehara S, Okuyama T, Shirai N, Yamashita H, Sugioka K, Kitamura H, Ujino K, Hozumi T, Yoshiyama M.
  • Journal Title: J Cardiol. 53 Pages: 257-264
  • NAID: 10025183266
  • Peer Reviewed
• [Journal Article] プラーク石灰化研究への誘い (2009)
  • Author(s): 江原省一
  • Journal Title: Coronary Intervention. Vol.5. No.5 Pages: 66-71
• [Journal Article] 問診と身体所見からリスクファクターを識る (2009)
  • Author(s): 江原省一
  • Journal Title: 新・心臓病プラクティス Pages: 138-142
• [Journal Article] メタボリックシンドロームと冠動脈リモデリング (2009)
  • Author(s): 江原省一
  • Journal Title: 分子心血管病 Vol.10. No.3 Pages: 27-32
• [Journal Article] コレステロールと動脈硬化の発症メカニズム (2009)
  • Author(s): 江原省一、上田真喜子
  • Journal Title: ライフサイエンス出版 Pages: 66-69
• [Journal Article] コレステロールと動脈硬化の発症メカニズム (2009)
  • Author(s): 江原省一、上田真喜子
  • Journal Title: コレステール-基礎から臨床へ- Pages: 66-69
• [Journal Article] メタボリックシンドロームと冠動脈リモデリング (2009)
  • Author(s): 江原省一
  • Journal Title: 分子心血管病 10 Pages: 27-32
• [Journal Article] All About IVUS :プラーク石灰化研究への誘い (2009)
  • Author(s): 江原省一
  • Journal Title: Coronary Intervention 5 Pages: 66-71
• [Journal Article] (2008)
  • Author(s): Okuyama T, Ehara S, Shirai N, Sugioka K, Ogawa K, Oe H, Kitamura H, Itoh T, Otani K, Matsuoka T, Inoue Y, Ueda M, Hozumi T, Yoshiyama M.
  • Journal Title: J Cardiol 52 Pages: 276-284
  • Peer Reviewed
• [Journal Article] Assessment of aortic atheromatous plaque and stiffness by 64-slice computed tomography is useful for identifying patients with coronary artery disease. (2008)
  • Author(s): Okuyama T, Ehara S, Shirai N, Sugioka K, Yamashita H, Kataoka T, Naruko T, Itoh T, Otani K, Matsuoka T, Inoue Y, Ueda M, Yoshikawa J, Hozumi T, Yoshiyama M.
  • Journal Title: Circ J. 72 Pages: 2021-2027
  • NAID: 110006987358
  • Peer Reviewed
• [Journal Article] Small coronary calcium deposits and elevated plasma levels of oxidized low density lipoprotein are characteristic of acute myocardial infarction. (2008)
  • Author(s): Ehara S, Naruko T, Shirai N, Itoh A, Hai E, Sugama Y, Ikura Y, Ohsawa M, Okuyama T, Shirai N, Yamashita H, Itabe H, Haze K, Yoshiyama M, Ueda M
  • Journal Title: J Atheroscler Thromb. 15 Pages: 75-81
  • NAID: 10022608007
  • Peer Reviewed
• [Journal Article] Morphological but not functional changes of the carotid artery are associated with the extent of coronary artery disease in patients with preserved left ventricular function. (2008)
  • Author(s): Sugioka K, Hozumi T, Iwata S, Oe H, Okuyama T, Shirai N, Yamashita H, Ehara S, Kataoka T, Yoshikawa J, Ueda M, Yoshiyama M.
  • Journal Title: Stroke 39 Pages: 1597-1599
  • Peer Reviewed
• [Journal Article] 拡張型心筋症 画像診断:(2)CT, MRI. (2008)
  • Author(s): 江原省一、吉川純一
  • Journal Title: 最新医学別冊 Pages: 118-127
• [Journal Article] 酸化LDLと冠動脈プラークの病理 (2008)
  • Author(s): 江原省一、葭山稔、上田真喜子
  • Journal Title: Angiology Frontier. Vol.7. NO.4 Pages: 19-24
• [Journal Article] どのような病態・冠動脈プラークが心血管系事故を起こすか? (2008)
  • Author(s): 江原省一
  • Journal Title: 新・心臓病プラクティス Pages: 7-13
• [Journal Article] プラーク不安定因子 (2008)
  • Author(s): 江原省一
  • Journal Title: MEDICAL TECHNOLOGY. Vol.36. No.4 Pages: 372-377
• [Journal Article] プラーク不安定性におけるneopterinの役割 (2008)
  • Author(s): 江原省一、上田真喜子
  • Journal Title: 医学のあゆみ Vol.224. No.5 Pages: 380-384
• [Journal Article] 冠動脈硬化症の成因 (2008)
  • Author(s): 江原省一、葭山稔、上田真喜子
  • Journal Title: 総合臨床 Vol.57. No.2 Pages: 204-210
• [Journal Article] 心血管イベント発症と脂質異常症 (2008)
  • Author(s): 江原省一、葭山稔、上田真喜子
  • Journal Title: Current Therapy. Vol.26. No.1 Pages: 23-27
• [Journal Article] 心血管イベント発症と脂質異常症 (2008)
  • Author(s): 江原 省一
  • Journal Title: Current Therapy 26 Pages: 23-27
• [Journal Article] 冠動脈硬化症の成因 (2008)
  • Author(s): 江原 省一
  • Journal Title: 総合臨床 57 Pages: 204-210
• [Journal Article] 心筋バイオマーカー・プラーク不安定化因子 (2008)
  • Author(s): 江原 省一
  • Journal Title: MEDICAL TECHNOLOGY 36 Pages: 372-377
• [Presentation] プラーク不安定化における炎症・酸化-抗酸化バランスとバイオマーカー:MPO、酸化LDL、パラオキソネース、およびネオプテリン (2008)
  • Author(s): 江原省一、白井伸幸、葭山稔、仲川将志、北林千津子、上田真喜子、成子隆彦、土師一夫、板部洋之
  • Organizer: 第56回日本循環器学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-09
• [Presentation] プラーク不安定化における炎症・酸化-抗酸化バランスとバイオマーカー : MPO、酸化LDL、パラオキソネース、ネオプテリン (2008)
  • Author(s): 江原 省一
  • Organizer: 第56回日本心臓病学会
  • Place of Presentation: 東京フォーラム
  • Year and Date: 2008-09-09
• [Presentation] Retardation of neointima tissue responses and thrombosis at the site of drug-eluting stents in human coronary arteries. (2008)
  • Author(s): Nakagawa M, Ikura Y, Arimoto J, Kitabayashi C, Ueda M, Ehara S, Shirai N, Yoshiyama M, Naruko T, Haze K.
  • Organizer: 第40回日本動脈硬化学会
  • Place of Presentation: つくば
  • Year and Date: 2008-07-11
• [Presentation] Obesity and dyslipidemia are characteristic of young patients with acute myocardial infarction in Japan. (2008)
  • Author(s): Ehara S, Shirai N, Sugioka K, Yoshiyama M, Nakagawa M, Kitabayashi C, Ikura Y, Ueda M, Naruko T, Haze K.
  • Organizer: 第40回日本動脈硬化学会
  • Place of Presentation: つくば
  • Year and Date: 2008-07-11
• [Presentation] New echocardiographic approach using real-time three-dimensional echocardiography in the clinica practice. (2008)
  • Author(s): Hozumi T, Fukuda S, Oe H, Sugioka K, Otsuka R, Ehara S, Ueda M, Yoshikawa J, Yoshiyama M.
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28
• [Presentation] Myeloperoxidase are associated with low density lipoprotein oxidation and unstable coronary syndrome in human. (2008)
  • Author(s): Ehara S, Naruko T, Nakagawa M, Kitabayashi C, Shirai N, Sugioka K, Oe H, Okuyama T, Hozumi T, Haze K, Itabe H, Yoshiyama M, Ueda M.
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28