Role and mechanism of thrombospondin in response to beta blocker therapy in patients with congestive heart failure
| Project/Area Number |
20590834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
TAKEMOTO Yasuhiko 大阪市立大学, 大学院・医学研究科, 非常勤講師 (20364002)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIYAMA Minoru 大阪市立大学, 大学院・医学研究科, 教授 (30240956)
AZUMA Jyunichi 兵庫医療大学, 薬学研究科, 教授 (30144463)
FUJIO Yasushi 大阪大学, 大学院・薬学研究科, 教授 (20359839)
MAEDA Makiko 兵庫医療大学, 大学院・薬学研究科, 講師 (70461168)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬剤応答性 / 循環器・高血圧 / 薬理学 / 臨床 / 内科 / 慢性心不全 / アドレナリンβ受容体遮断薬 / 血管内皮機能 / 左室収縮能 / 遺伝子多型 / 拡張型心筋症 / トロンボスポンジン / 薬剤反応性 / 血管内皮機能改善 / 左室収縮能改善 |
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| Research Abstract |
We evaluated Ala523Thr polymorphism(G/A) and thrombospondin-1 plasma levels in nonischemic congestive heart failure patients before, 6, and 12 months after administration of beta blocker therapy and in normal healthy volunteers. There were no significant differences of thrombospondin-1 plasma levels between GG group and non GG group in normal healthy volunteers. No significant differences of thrombospondin-1 plasma levels were found between GG group and non GG group in nonischemic congestive heart failure patients. There were significant correlations between changes in BNP levels from before to 12 months after administration of beta blocker therapy and those in plasma thrombospondin-1 levels. Thrombospondin-1 may play a role in hemodynamic optimization at the chronic stage of nonischemic congestive heart failure.
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Report
(4 results)
Research Products
(102 results)
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[Presentation] The Association of Osteopontin with Cardiac Fibrosis and the Responsiveness to Beta-blockers in Patients with Heart Failure2008
Author(s)
Okamoto, H., Fujio, Y., Takemoto, Y., Yoshiyama, M., Azuma, J.
Organizer
American Heart Association
Place of Presentation
New Orleans, USA
Year and Date
2008-11-11
Related Report
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[Presentation] Combined genotype of norepinephrine transporter T-182C and alpha2c adrenergic receptor deletion polymorphisms is associated with the response to beta-blockers in dilated cardiomyopathy2008
Author(s)
Nonen, S., Fujio, Y., Takemoto, Y., Yoshiyama, M., Azuma, J.
Organizer
World Conference on Clinical Pharmacology and Therapeutics
Place of Presentation
Quebec, Canada
Year and Date
2008-07-28
Related Report
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