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Investigation of a novel a cardiovascular inflammation marker, Pentraxin 3

Research Project

Project/Area Number 20590840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionJuntendo University

Principal Investigator

INOUE Kenji (INOUE Kenii)  順天堂大学, 医学部, 准教授 (80317388)

Co-Investigator(Kenkyū-buntansha) SUWA Satoru  順天堂大学, 医学部, 先任准教授 (90226613)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsバイオマーカー / 急性冠症候群 / 胸痛 / 睡眠時無呼吸症候群 / 臨床 / 動脈硬化
Research Abstract

In Japan as well as industry countries, the mortality caused by cardiovascular disease is worst. General practitioners are expected to make a diagnosis of such disease although they are not cardiologist. ECG or UCG are useful tools to make a diagnosis for such disease, but still, they require specific technique to make a diagnosis. We established a novel cardiovascular marker, Pentraxin 3 (PTX3). Only 0.1mL blood sample reflect the status of the inflammation of vascular. In this study, we have reported that PTX3 was a useful marker to predict the prognosis for patients with acute coronary syndrome, or sleep apnea syndrome.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009 2008

All Journal Article (26 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Human pentraxin 3 (PTX3) as a novel biomarker for the diagnosis of pulmonary arterial hypertension2012

    • Author(s)
      Tamura Y, Inoue K, Fukuda K et al
    • Journal Title

      PLoS One

      Volume: 7(9)

    • Related Report
      2011 Final Research Report
  • [Journal Article] The proteomic profile ofcirculating pentraxin 3 (PTX3) complex insepsis demonstrates the interaction withazurocidin 1 and other components ofneutrophil extracellular traps2012

    • Author(s)
      Daigo K, Inoue K, Hamakubo T.et al
    • Journal Title

      MolCell Proteomics

      Volume: 11(6)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pentraxin 3 (PTX 3) Released from Neutrophils Increases Plasma PTX3 levels in Patients with Acute Coronary Syndrome2012

    • Author(s)
      Inoue K, S Daida H
    • Journal Title

      ISRN Vascular Medicine

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pentraxin 3: A Novel Biomarker for Inflammatory Cardiovascular Disease2012

    • Author(s)
      Inoue K, Kodama T Daida H et al
    • Journal Title

      Int J Vasc Med

      Pages: 657025-657025

    • Related Report
      2011 Final Research Report
  • [Journal Article] Pentraxin 3 : A Novel Biomarker for Inflammatory Cardiovascular Disease2012

    • Author(s)
      Inoue K, Kodama T, Daida H
    • Journal Title

      International Journal of Medicine

      Volume: (Epub Jan 4) Pages: 1-6

    • DOI

      10.1155/2012/657025

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart Fatty Acid-Binding Protein Offers Similar Diagnostic Performance to High-Sensitivity Troponin T in Emergency Room Patients Presenting With Chest Pain2011

    • Author(s)
      Inoue K, Daida H.et al
    • Journal Title

      Circ J

      Volume: 75(12) Pages: 2813-20

    • Related Report
      2011 Final Research Report
  • [Journal Article] Plasma Pentraxin3 and Arterial Stiffness in Men With Obstructive Sleep Apnea2011

    • Author(s)
      Kasai T, Inoue K, Narui K. et al
    • Journal Title

      Am J Hypertens

      Volume: 24(4) Pages: 401-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Heart Fatty Acid-Binding Protein Offers Similar Diagnostic Performance to High-Sensitivity Troponin T in Emergency Room Patients Presenting With Chest Pain2011

    • Author(s)
      Inoue K, Suwa S, Ohda, H, et al
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 2813-2820

    • NAID

      10030033303

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentraxin 3 (PTX 3) Released from Neutrophils Increases Plasma PTX3 levels in Patients with Acute Coronary Syndrome2011

    • Author(s)
      Inoue K, Suwa S, Okazaki S, et al
    • Journal Title

      ISRN Vascular Medicine

      Volume: 2011 Pages: 1-6

    • DOI

      10.5402/2011/358426

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma Pentraxin3 and Arterial Stiffness in Men With Obstructive Sleep Apnea.2010

    • Author(s)
      Kasai T, Inoue K, Kumagai T, Kato M, Kawana F, Sagara M, Ishiwata S, Ohno M, Yamaguchi T, Momomura SI, Narui K.
    • Journal Title

      Am J Hypertens.

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] A novel cardiovascular marker ; pentraxin 32010

    • Author(s)
      井上健司
    • Journal Title

      The Lipid vol.21, No.1

      Pages: 38-42

    • NAID

      40016914109

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] 新規血管炎症マーカー2010

    • Author(s)
      井上健司
    • Journal Title

      日本臨床増刊号広範囲血液・尿化学検査免疫学的検査第7版

      Pages: 862-865

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] 特集, ゲノム解析で見つかったProtein Markerの意義-PTX3は新たな炎症マーカーとして認知されるか-2010

    • Author(s)
      井上健司
    • Journal Title

      序と総説生物試料分析 Vol.33, No.4

      Pages: 289-297

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Plasma pentraxin 3 and arterial stiffness in men with obstructive sleep apnea2010

    • Author(s)
      Kasai T, Inoue K, Kumagai T, Kato M, Kawana F, Sagara M, Iwashita S, Ohono M, Yamaguchi T, Momomura S, Narui K
    • Journal Title

      American Journal of Hypertension. 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集;ゲノム解析で見つかったProtein Markerの意義-PTX3は新たな炎症マーカーとして認知されるか-序と総説2010

    • Author(s)
      井上健司
    • Journal Title

      生物試料分析

      Volume: 4 Pages: 289-297

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 新規血管炎症マーカー2010

    • Author(s)
      井上健司
    • Journal Title

      日本臨床増刊号 広範囲 血液・尿化学検査 免疫学的検査

      Volume: 7 Pages: 862-865

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations2009

    • Author(s)
      Yamasaki K, Kurimura M, Kasai T
    • Journal Title

      Inoue K**corresponding author Clin Chem Lab Med

      Volume: 47(4) Pages: 471-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Determination of physiological plasma pentraxin3(PTX3)levels in healthy populations.2009

    • Author(s)
      Yamasaki K, Kurimura M, Kasai T, Sagara M, Kodama T, Inoue K
    • Journal Title

      Clin Chem Lab Med. 47(4)

      Pages: 471-477

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] 新規血管炎症マーカー, pentraxin32009

    • Author(s)
      井上健司
    • Journal Title

      Heart View vol.13, No.6

      Pages: 56-61

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] 新規血管炎症マーカー2009

    • Author(s)
      井上健司
    • Journal Title

      細胞 vol.41, No.11

      Pages: 454-457

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Determination of physiological plasma pentraxin 3(PTX3)levels in healthy populations2009

    • Author(s)
      Yamasaki K, Kurimura M, Kasai T, Sagara M, Kodama T, Inoue K
    • Journal Title

      Clin Chem Lab Med.2009 ; 47(4)

      Pages: 471-477

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規血管炎症マーカー, pentraxin 32009

    • Author(s)
      井上健司
    • Journal Title

      Heart View 13

      Pages: 56-61

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A novel cardiovascular marker ; pentraxin 32009

    • Author(s)
      井上健司
    • Journal Title

      The Lipid 21

      Pages: 38-42

    • NAID

      40016914109

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 新規血管炎症マーカー, pentraxin 32009

    • Author(s)
      井上健司
    • Journal Title

      細胞 41

      Pages: 454-457

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 新規血管炎症マーカー, pentraxin32008

    • Author(s)
      井上健司
    • Journal Title

      医学のあゆみ vol.224

      Pages: 353-357

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] バイオマーカー2008

    • Author(s)
      井上健司
    • Journal Title

      Medical View

    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Clinical Prediction Rules for Bactereia Based on Appetitie at The Time of Blood Culture2011

    • Author(s)
      Komatsu T, Onda T, Inoue K, et al
    • Organizer
      49th Annual Meeting of the Infectious Disease Society of America (IDSA)
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] シンポジウム7:凝固線溶系検査と病態解析, 新規血管炎症性マーカーPentraxin32010

    • Author(s)
      井上健司
    • Organizer
      日本臨床検査医学会第57回学術集会指名講演
    • Year and Date
      2010-09-11
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 新規血管炎症性マーカーPentraxin 32010

    • Author(s)
      井上健司
    • Organizer
      日本臨床検査医学会第57回学術集会指名講演
    • Place of Presentation
      京王ホテル
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pentraxin 3(PTX3)Predicts Serious Outcome in Patients with Chest Pain2010

    • Author(s)
      Inoue K, Suwa S, Okazaki S Daida H
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pentraxin3(PTX3)Predicts Serious Outcome in Patients with Chest Pain2010

    • Author(s)
      Inoue K, Suwa S, Okazaki S, Okai I, Maruyama S, Ito S, Fujiwara Y,Sumiyoshi M, Diada H
    • Organizer
      日本循環器学会JCS2010-第22回日本循環器学会総会・学術集会
    • Place of Presentation
      oral presentation
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Prognostic Value of Pentaxin3 in Patients with Chest Pain2009

    • Author(s)
      Inoue K, Suwa S, Okazaki S, Ito S, Kawamura M, Kodama T, Daida H
    • Organizer
      European society of cardiology congress 2009
    • Place of Presentation
      バルセロナ
    • Year and Date
      2009-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] @ Measurement of PTX3 Combined With 64-Slice CT Angiography Reduces The False Positive Rate For The Diag nosis of Coronary Artery Disease. @ Prognostic Value of Pentaxin3 in Patients with Chest Pain2009

    • Author(s)
      岡井巌諏訪哲
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Measurement of PTX3 Combined with 64-Slice CT Angiography Reduces the False Positive Rate for the Diagnosis of Coronary Artery Disease2009

    • Author(s)
      Okai I, Inoue K, Okazaki S, Komatsu K, Maruyama S, Fujiwara Y, Sagara M, Kodama T, Daida H
    • Organizer
      日本循環器学会JCS2009-第21回日本循環器学会総会・学術集会Featured research Session
    • Place of Presentation
      oral presentation
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Prognostic Value of Pentaxin3 in Patients with Chest Pain2009

    • Author(s)
      Suwa S, Inoue K, Maruyama S, Ito S, Okazaki S, Sumiyoshi M, Kodama T, Diada H
    • Organizer
      日本循環器学会JCS2009-第21回日本循環器学会総会・学術集会
    • Place of Presentation
      poster session
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] European society of cardiology congress2009

    • Author(s)
      Inoue K, Suwa S, Okazaki S, Ito S, Kawamura M, Kodama T, Diada H
    • Organizer
      Prognostic value of pentaxin3 in patients with chest pain
    • Place of Presentation
      oral presentation
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] European society of cardiology congress2008

    • Author(s)
      Inoue K, Suwa S, Okazaki S, Sagara M, Salvchenko A, Ito S, Naito M, Diada H
    • Organizer
      The involvement of neutrophils in the increased plasma pentraxin3 levels in patients with acute coronary syndrome.
    • Place of Presentation
      Kodama
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 全身性炎症反応症候群の治療又は予防剤2012

    • Inventor(s)
      浜窪 隆雄,津本 浩平,太期 健二,井上 健司,山口 尚敬,水内 素晶
    • Industrial Property Rights Holder
      浜窪 隆雄,津本 浩平,太期 健二,井上 健司,山口 尚敬,水内 素晶
    • Filing Date
      2012-06-22
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 心血管イベント発症リスクの診断方法2008

    • Inventor(s)
      井上健司、代田浩之、濱田里子、向井済、相良三奈
    • Industrial Property Rights Holder
      井上健司、代田浩之、濱田里子、向井済、相良三奈
    • Industrial Property Number
      2008-144235
    • Acquisition Date
      2008-06-02
    • Related Report
      2011 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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