| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Alodosterone plays a key role in the pathogenesis of heart failure. In addition to the classical adrenocortical aldosterone synthesis pathway, we have previously reported that aldosterone is also produced in the heart. In this study, we demonstrated that N-type Calcium channel which has been indentified exclusively in sympathetic nerve terminals actually regulates aldosterone production in adrenal grands. Moreover, we found that aldosterone production in the heart is deeply affected by glucose and/or sodium condition. These results further elucidate the contribution of sodium and glucose condition to the pathophysiological significance in the cardiovascular diseases, and will lead to the development of novel therapeutic approach in the future.
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