| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
Ischemic preconditioning (PC) is the phenomenon whereby brief episodes of ischemia render the heart more resistant to the subsequent ischemia. To determine the mechanisms of PC in human, we sought the differences between the PC positive group and the PC negative group during percutaneous coronary intervention. We found the following findings. 1) The marker reflecting reactive oxygen species injury increased in coronary sinus after the brief myocardial ischemia only in the PC positive group, but not in the PC negative group. 2) Patients with obesity related-genes abnormality were more frequent in PC negative group. Thus, reactive oxygen species and a factor related with obesity related-gene abnormality may involve the mechanisms of PC in human.
|
