Investigation of the mechanisms of myocardial protection afforded by ischemic preconditioning in human
| Project/Area Number |
20590842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TAKANO Hitoshi Nippon Medical School, 医学部, 講師 (90277533)
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| Co-Investigator(Kenkyū-buntansha) |
YASUTAKE Masahiro 日本医科大学, 医学部, 准教授 (70281433)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 虚血再灌流傷害 / 心筋保護 / 活性酸素種 / 肥満遺伝子 |
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| Research Abstract |
Ischemic preconditioning (PC) is the phenomenon whereby brief episodes of ischemia render the heart more resistant to the subsequent ischemia. To determine the mechanisms of PC in human, we sought the differences between the PC positive group and the PC negative group during percutaneous coronary intervention. We found the following findings. 1) The marker reflecting reactive oxygen species injury increased in coronary sinus after the brief myocardial ischemia only in the PC positive group, but not in the PC negative group. 2) Patients with obesity related-genes abnormality were more frequent in PC negative group. Thus, reactive oxygen species and a factor related with obesity related-gene abnormality may involve the mechanisms of PC in human.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article]2011
Author(s)
Kiriyama T, Fukushima Y, Takano H, Mizuno K, Kumita
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Journal Title
Related Report
Peer Reviewed
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