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Investigation on Multi-biomarker Strategy by novel coronary imagings

Research Project

Project/Area Number 20590843
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNippon Medical School

Principal Investigator

SEINO Yoshihiko  Nippon Medical School, 医学部, 教授 (10163073)

Co-Investigator(Kenkyū-buntansha) 高野 雅充  日本医科大学, 医学部, 助教 (40287719)
村上 大介  日本医科大学, 医学部, 助教 (70445782)
山本 真功  日本医科大学, 医学部, 助教 (90449265)
雪吹 周生  日本医科大学, 医学部, 助教 (80193639)
大場 崇芳  日本医科大学, 医学部, 助教 (00516015)
Co-Investigator(Renkei-kenkyūsha) IBUKI Chikao  日本医科大学, 医学部, 講師 (80193639)
TAKANO Masamichi  日本医科大学, 医学部, 講師 (40287719)
OHBA Takayoshi  日本医科大学, 医学部, 助教 (00516015)
MURAKAMI Daisuke  日本医科大学, 医学部, 助教 (70445782)
YAMAMOTO Masanori  日本医科大学, 医学部, 助教 (90449265)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsOptical coherence tomography / vulnerable plaque / biomarker / high sensitivity troponin T / NT-proBNP / sLOX-1 / MMP-9 / 冠動脈画像解析 / 不安定プラーク / バイオマーカー / 睡眠時無呼吸 / 高感度トロポニン
Research Abstract

The present investigation for the development of multi-biomarker strategy in coronary artery disease revealed importance of the detail analyses concerning the plaque tissue and fibrous cap components by the combination of novel coronary imaging (coronary angioscope, intravascular ultrasound, and optical coherence tomography) and cardiovascular biomarkers. Sequential observation in novel coronary imaging following the coronary stent implantation (BMS versus DES) demonstrated marked differences in the neointimal formation between BMS and DES, especially the development of neovascular microchannels in DES restenosis site, which should suggest the necessity of the development of further new marker reflecting neovascular formation. As the novel biomarker for the most upstream of plaque vulnerability, the present investigation demonstrated usefulness of the combination of sLOX-1, MMP-9, MPO,high-sensitivity troponin T and NT-proBNP. These assessment and OCT analysis revealed high prevalence of high-risk plaque for peri-procedural myocardial injury following percutaneous coronary intervention even in patients with stable coronary artery disease, which was mostly characterized by larger angle of lipid plaque and thinner fibrous cap at the culprit lesion by OCT, namely, silent vulnerable plaque or the upstream vulnerable plaque.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 2008

All Journal Article (48 results) (of which Peer Reviewed: 47 results) Presentation (29 results) Book (4 results)

  • [Journal Article] Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 as an Early Biomarker for ST Elevation Myocardial Infarction2011

    • Author(s)
      Kobayashi N, Hata N, Kume N, Seino Y, Inami T, Yokoyama S, Shinada T, Tomita K, Kaneshige T, Mizuno K
    • Journal Title

      E pub75(6)(online)

      Pages: 1433-1439

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography analysis for restenosis of drug-Eluting stents2011

    • Author(s)
      Yamamoto M, Takano M, Murakami D, Inami T, Kimata N, Inami S, Okamatsu K, Ohba T, Seino Y, Mizuo K
    • Journal Title

      International Journal of Cardiology 146(1)

      Pages: 100-103

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Late vascular responses from 2 to4 years after implantation of sirolimus-eluting stents : Serial observations by intracoronary optical coherence tomography2011

    • Author(s)
      Takano M, Yamamoto M, Mizuno M, Murakami D, Inami T, Kimata N, Murai K, Kobayashi N, Okamatsu K, Seino Y, Mizuno K
    • Journal Title

      Circulation Cardiovascular Interventions 3(5)

      Pages: 476-489

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography analysis for restenosis of drug-eluting stens2011

    • Author(s)
      Yamamoto M, Takano M, Murakami D, Inami T, Kimata N, Inami S, Okamatsu K, Ohba T, Seino Y, Mizuno K
    • Journal Title

      International Journal of Cardiology

      Volume: 146(1) Pages: 100-103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of small thrombus formation in restenotic bare-metal stent lesions associated with acute coronary syndrome : Identification by optical coherence tomography2011

    • Author(s)
      Yamamoto M, Takano M, Murakami D, Inami T, Kobayashi N, Shirakabe A, Inami S, Kokamatsu K, Ohba T, Aoki S, Seino Y, Mizuno K
    • Journal Title

      International Journay of Cardiology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delayed Healing of a Coronary Stent Granft2011

    • Author(s)
      Takano M, Yamamoto M, Inami T, Murakami D, Seino Y, Mizuno K
    • Journal Title

      Cardiovascular Interventions

      Volume: 4(4) Pages: 466-467

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated peripheral blood mononuclear cell count is an independent predictor of left ventricular remodeling in patients with acute myocardial infarction2011

    • Author(s)
      Aoki S, Nakagomi A, Asai K, Takano H, Yasutake M, Seino Y, Mizuno K
    • Journal Title

      Journal of Cardiology

      Volume: 57 Pages: 202-207

    • NAID

      10031159563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble Lection-Like Oxidized Low-Density Lipoprotein Recepter 1 as an Early Biomarker for ST Elevation Myocardial Infarction2011

    • Author(s)
      Kobayashi N, Hata N, Kume N, Seino Y, Inami T, Yokoyama S, Shinada T, Tomita K, Kaneshige T, Mizuno K
    • Journal Title

      Circulation Journal

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Refractory coronary spastic angina may induce sudden cardiac death even in young patients under appropriate medication2011

    • Author(s)
      Murakami D, Negishi K, Yamamoto M, Tokuyama H, Kobayashi N, Takano M, Seino Y, Mizuno K
    • Journal Title

      International Journal of Cardiology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of Monocyte Proinflammatory Cytokine Production by C-Reactive Protein is Significantly Related to Ongoing Myocardial Damage and Future Cardiac Events in Patients With Chronic Heart Failure2010

    • Author(s)
      Nakagomi S, Seino Y, Endoh Y, Kusama Y, Atarashi H, Mizuno K
    • Journal Title

      Journal of Cardiac Failure 16(7)

      Pages: 562-571

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neovascular microchannels in sirolimus-eluting stent occlusion at last phase2010

    • Author(s)
      Takano M, Yamamoto M, Seino Y, Mizuno K
    • Journal Title

      JACC : Cardiovascular Interventions 13(11)

      Pages: 1202-1203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical Coherence tomography after new scoring balloon angioplasty for in-stent restenosis and de novo coronary lesion2010

    • Author(s)
      Takano M, Yamamoto M, Murakami D, Takano H, Asai K, Yasutake M, Seino Y, Mizuno K
    • Journal Title

      International Journal of Cardiology 141(3)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of Smoking Status to Serum Level of N-Terminal Pro-Brain NatriureticPeptide in Middle-Agged Men Without Overt Cardiovascular Disease2010

    • Author(s)
      Otsuka T, Kawada T, Seino Y, Ibuki C, Katsumata M, Kodani E
    • Journal Title

      American Journal of Cardiology 106(10)

      Pages: 1456-1460

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal pro-BNP is a novel biomarker for integrated cardio-renal burden and early risk stratification in patients admitted for cardiac emergency2010

    • Author(s)
      Yamashita T, Seino Y, Ogawa A, Ogata M, Fukushima M, Tanaka K, Mizuno K
    • Journal Title

      Journal of Cardiology 55(3)

      Pages: 377-383

    • NAID

      10027052747

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Appearance of Lipid-Laden Intima and Neovascularization After Implantation of Bare-Metal Stents2010

    • Author(s)
      Takano M, Yamamoto M, Inami S, Murakami D, Ohba T, Seino Y, Mizuno K
    • Journal Title

      Journal of American College of Cardiology 55

      Pages: 26-32

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of Monocyte Proinflammatory Cytokine Production by C-Reactive Protein is Significantly Related to Ongoing Myocardial Damage and Future Cardiac Events in Patients With Chronic Heart Failure2010

    • Author(s)
      Nakagomi A, Seino Y, Endoh Y, Kusama Y, Atarashi H, Mizuno K
    • Journal Title

      Journal of Cardiac Failure

      Volume: 16(7) Pages: 562-571

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neovascular microchannels in sirolimus-eluting stent occlusion at last phase2010

    • Author(s)
      Takano M, Yamamoto M, Seino Y, Mizuno K
    • Journal Title

      JACC : Cardiovascular Interventions

      Volume: 3(11) Pages: 1202-1203

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Coherence tomography after new scoring balloon angioplasty for in-stent restenosis and de novo coronary lesion2010

    • Author(s)
      Takano M, Yamamoto M, Murakami D, Takano H, Asai K, Yasutake M, Seino Y, Mizuno K
    • Journal Title

      Internationall Journal of Cardiology

      Volume: 141(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reccurent very late thrombosis of drug-eluting stent : optical coherence tomography findings2010

    • Author(s)
      Kobayashi N, Takano M, Hata N, Yamamoto M, Shinada T, Takahashi Y, Tomita K, Kitamura M, Kurihara O, Mizuno K
    • Journal Title

      Journal of Cardiology Cases

      Volume: 2(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography findings in a case of acute myocardial infarction caused by coronary vasospasm2010

    • Author(s)
      Kobayashi N, Takano M, Hata N, Yamamoto M, Shinada T, Takayoshi Y, Tomita K, Kitamura M, Mizuno K
    • Journal Title

      International Heart Journal

      Volume: 51(4) Pages: 291-292

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombus in sirolimus-eluting stent identified by optical coherence tomography2010

    • Author(s)
      Takano M, Yamamoto M, Seino Y, Mizuno K
    • Journal Title

      Clinical Cardiology

      Volume: 33(12)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late vascular responses from 2 to 4 years after implalltation of sirolimus-eluting stents : Serial observations by intracoronary optical coherence tomography2010

    • Author(s)
      Takano M, Yamamoto M, Mizuno M, Murakami D, Inami T, Kimata N, Murai K, Kobayashi N, Okamatsu K, Ohba T, Seino Y, Mizuno K
    • Journal Title

      Circulation Cardiovascular Interventions

      Volume: 3(5) Pages: 476-489

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal pro-BNP is a novel biomarker for integrated cardio-renal burden and early risk stratification in patients dmitted for cardiac emergency2010

    • Author(s)
      Yamashita T, Seino Y, Ogawa A, Ogata K, Fukushima M, Tanaka, K, Mizuno K
    • Journal Title

      Journal of Cardiology

      Volume: 55(3) Pages: 377-377

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of Smoking Status to Serum Level of N-Terminal Pro-Brain Natriuretic Peptide in Middle-Agged Men Without Overt Cardiovascular Disease2010

    • Author(s)
      Otsuka T, Kawada T, Seino Y, Ibuki C, Katsumata M, Kodan E
    • Journal Title

      American Journal of Cardiology

      Volume: 106(10) Pages: 1456-1460

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal pro-BNP is a novel biomarker for integrated cardio-renal burden and early risk stratification in patients admitted for cardiac emergency2010

    • Author(s)
      Teruyo Yamashita, Yoshihiko Seino, Akio Ogawa, Ken-ichi Ogata, Masato Fukushima, keiji Tanaka, Kyoichi Mizuno
    • Journal Title

      Journal of Cardiology 55

      Pages: 377-383

    • NAID

      10027052747

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between neointimal coverage of Sirolimus-eluting stents and lesion characteristics S study with serial coronary angioscopy2009

    • Author(s)
      Yamamoto M, Okamatsu K, Inami S, Takano M,Yokoyama S, Ohba T, Ibuki C, Hata N, Seino Y, Mizuno K
    • Journal Title

      American Heart Journal 58(1)

      Pages: 99-104

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性冠症候群:冠先端画像とバイオマーカー2009

    • Author(s)
      清野精彦
    • Journal Title

      進歩する心臓研究 29

      Pages: 35-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マルチバイオマーカーを用いた急性冠症候群2009

    • Author(s)
      清野精彦
    • Journal Title

      分子血管病 10(6)

      Pages: 46-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevation of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009

    • Author(s)
      Yamamoto M, Seino Y, Okamatsu K, Inami T, Murakami D, Ohba T, Aoki S, Ibuki C, Takano M, Mizuno K, Hata N
    • Journal Title

      Circulation 120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Link of Sleep Apnea Syndrome to Coronary Atheroseclerotic Burden and Elevated Cardiac Biomarkers in Stable Coronary Artery Disease Patient2009

    • Author(s)
      Inami T, Seino Y, Yamamoto M, Kimata N, Murakami D, Takano M,Ohba T, Aoki S, Ibuki C, Mizuno K
    • Journal Title

      Circulation 120

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Various optical coherence tomographic findings in restenotic lesions after Sirolimus-eluting stent implantation2009

    • Author(s)
      Takano M, Xie Y, Murakami D, Inami S, Yamamoto M, Ohba T, Seino Y, Mizuno K
    • Journal Title

      International Journal of Cardiology 134(2)

      Pages: 263-265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Appnearance of Lipid-Laden Intima and Neovascularization After Implantation of Bare-Metal Stents2009

    • Author(s)
      Masamichi Takano, Masanori Yamamoto, Shigenobu Inami, Daisuke Murakami, Takayoshi Ohba, Yoshihiko Seino, Kyoichi Mizuno
    • Journal Title

      Journal of American College of Cardiology 55

      Pages: 26-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extended Follow-Up by Serial Angioscopic Observation for Bare-Metal Stents in Native Coronary Arteries : From Healing Response to Atherosclerotic Transformation of Neointima2009

    • Author(s)
      Shinya Yokoyama, Masamichi Takano, Masanori Yamamoto, Shigenobu Inami, Shunta Sakai, Kentaro Okamatsu, Shinichi Okuni, Koji Seimiya, Daisuke Murakami, Takayoshi Ohba, Ryota Uemura, Yoshihiko Seino, Noritale Hata, Kyoichi Mizuno
    • Journal Title

      Circulation : Cardiovasc Intervent 2

      Pages: 205-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between neointimal coverage of sirolimus-eluting stents and lesion characteristics : S study with serial coronary angioscopy2009

    • Author(s)
      Masanori Yamamoto, Kentaro Okamatsu, Shigenobu Inami, Masamichi Takano, Shinya Yokoyama, Takayoshi Ohba, Chikao Ibuki, Noritake Hata, Yoshihiko Seino, Kyoichi Mizuno
    • Journal Title

      American Heart Journal 2

      Pages: 99-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性冠症候群: 冠先端画像とバイオマーカー2009

    • Author(s)
      清野精彦
    • Journal Title

      進歩する心臓研究 29

      Pages: 35-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マルチバイオマーカーを用いた急性冠症候群2009

    • Author(s)
      清野精彦
    • Journal Title

      分子血管病 10

      Pages: 46-50

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Elevation of soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009

    • Author(s)
      Masanori Yamamoto, Yoshihiko Seino, Kentaro Okamatsu, Toru Inami, Daisuke Murakami, Takayoshi Ohba, Satoshi Aoki, Chikao Ibuki, Masamichi Takano, Kyoichi Mizuno, Noritake Hata
    • Journal Title

      Circulation 120

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Link of Sleep Apnea Syndrome to Coronary Atherosclerotic Burden and Elevated Cardiac Biomarkers in Stable Coronary Artery Disease Patient2009

    • Author(s)
      Toru Inami, Yoshihiko Seino, et al.
    • Journal Title

      Circulation 120

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生化学マーカー2009

    • Author(s)
      清野精彦
    • Journal Title

      救急医学 特集 : 急性冠症候群 up to date 33

      Pages: 155-160

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4 . 冠動脈先端画像診断 : 血管内視鏡を用いた急性冠症候群の洞察(II)2009

    • Author(s)
      岡松健太郎, 清野精彦, 水野杏一
    • Journal Title

      日医大医会誌 5

      Pages: 6-8

    • NAID

      130004471407

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term follow-up evaluation after sirolimus-elutingstent implantation by optical coherence tomography : de novo coved struts persist?2008

    • Author(s)
      Takano M, Yamamoto M, Inami S, Murakami D, Seimiya K, Ohba T, Seino Y, Mizuno k
    • Journal Title

      Journal of the American College of Cardiology 51(9)

      Pages: 968-969

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of neointimal coverage by optical coherence tomography of a sirolimus eluting stent versus a bare-metal stent three months after implantation2008

    • Author(s)
      Xie Y, Takano M, Murakami D, Yamamoto M, Okamatsu K, Inami T, Seimiya K, Ohba T, Seino Y, Mizuno K
    • Journal Title

      American Journal of Cardiology 102(1)

      Pages: 27-31

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated levels of both cardiomyocyte membrane and myofibril damage markers predict adverse outcomes in patients with chronic heart failure2008

    • Author(s)
      Setsuta K, Seino Y, Kitahara Y, Arau M, Ohbayashi T, Takano T, Mizuno K
    • Journal Title

      Circulation Journal 72(4)

      Pages: 569-574

    • NAID

      110006656899

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of association large angiographic late loss and low risk of in-stent thrombus : angioscopic comparison between paclitaxel- and sirolimus-eluting stent2008

    • Author(s)
      Takano M, Yamamoto M, Murakami D, Inami S, Okamatsu K, Seimiya, K, Ohba T, Seino Y, Mizuno K
    • Journal Title

      Circulation : Cardiovascular Interventions2008 1

      Pages: 20-27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term follow-up evaluation after sirolimus-eluting stent implantation by optical coherence tomography : do uncoved struts persist?2008

    • Author(s)
      Takano M, Yamamoto M, Inami S, Murakami D, Seimiya K, Ohba T, Seino Y, Mizuno K
    • Journal Title

      Journal of American College of Cardiology 51

      Pages: 968-969

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of neointimal coverage by optical coherence tomography of a sirolimus-eluting stent versus a bare-metal stent three monthsafter implantation2008

    • Author(s)
      Xie Y, Takano M, Murakami D Yamamoto M, Okamatsu K, Inami S, Seimiya K, Ohba T. Seino Y, Mizuno K
    • Journal Title

      American Journal of Cardiology 102

      Pages: 27-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Various optical coherence tomographic findings in restenotic lesions after Sirolimus-eluting stent implantation2008

    • Author(s)
      Takano M, Xie Y, Murakami D Inami S, Yamamoto M, Ohba T, Seino Y, Mizuno K
    • Journal Title

      International Journal of Cardiology (Epub a Head print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated levels of both cardiomyocyte membrane and myofibril damage markers predict adverse outcomes in patients with chronic heart failure2008

    • Author(s)
      Setsuta K, Seino Y, Kitahara Y Arau M, Ohbayashi T, Takano T, Mizuno K
    • Journal Title

      Circulation Journal 72

      Pages: 569-574

    • NAID

      110006656899

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ACE-1 or ARB Have a Potential Effect to improve endothelial Dysfunction 6 months after SES Implantation2011

    • Author(s)
      Murakami D, Takano M, Kimata N, Inami T, Murai K, Ohba T, Ibuki C, Seino Y, Mizuno K
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微小心筋障害の進展と対策-心血管バイオマーカーで探る2010

    • Author(s)
      清野精彦
    • Organizer
      第109回日本循環器学会九州地方会
    • Place of Presentation
      長崎
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性冠症候群と冠攣縮性狭心症の鑑別におけるsLOX-1の有用性2010

    • Author(s)
      小林宣明, 畑典武, 久米典昭, 品田卓郎, 富田和憲, 北村光信, 白壁章宏, 野崎文, 徳山榮男, 稲見徹, 清野精彦, 水野杏一
    • Organizer
      第58回日本心臓病学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biomarkers Strategy2010

    • Author(s)
      清野精彦
    • Organizer
      第14回日本心不全学会(シンポジウム)
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Biomarkers Strategy2010

    • Author(s)
      Seino Y
    • Organizer
      第14回日本心不全学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 薬剤溶出性ステント留置後の新生内膜被覆を与える病変背景に関する血管内視鏡を用いた検討2010

    • Author(s)
      山本真功, 岡松健太郎, 高野雅充, 栗原理, 志村徹郎, 根岸経太, 稲見徹, 村上大介, 大場崇芳, 清野精彦, 水野杏一
    • Organizer
      第24回日本心臓血管内視鏡学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管内視鏡ならびにOCTによるvulnerable plaqueの評価2010

    • Author(s)
      高野雅充, 村上大介, 山本真功, 清野精彦, 水野杏一
    • Organizer
      第24回日本心臓血管内視鏡学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性心不全患者における単球の産生するサイトカインと血清脂質値,長期予後との関係2010

    • Author(s)
      中込明裕, 浅井俊之, 小杉宗範, 吉川雅智, 小谷栄太郎, 草間芳樹, 清野精彦, 新博次, 水野杏一
    • Organizer
      第58回日本心臓病学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACE-1 or ARB improve endothelial dysfunction 6 months after SES implantation2010

    • Author(s)
      Murakami D, Yamamoto M, Katayama N, Inami T, Takano M, Ohba T, Ibuki C, Seino Y, Mizuno K
    • Organizer
      CVIT2010日本心血管インターベンション治療学会
    • Place of Presentation
      官城県
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 微小心筋障害の進展と対策-心血管バイオマーカーで探る2010

    • Author(s)
      清野精彦
    • Organizer
      第109回日本循環器学会九州地方会
    • Place of Presentation
      長崎ブリックホール(教育講演)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 心筋障害の進展:心血管バイオマーカーで迫る2010

    • Author(s)
      清野精彦
    • Organizer
      第216回日本循環器学会関東甲信越地方会
    • Place of Presentation
      東京ステーションコンファレンス(教育講演)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 心筋傷害の進展:心血管バイオマーカーで迫る2010

    • Author(s)
      清野精彦
    • Organizer
      第216回日本循環器学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Very Late Thrombosis Originating from Bare-Metal Stent Segment during Extended Long-Term Follow-Up insights from Optical Coherence Tomography and Angioscopic Observations2010

    • Author(s)
      Masamichi Takano, Masanori Yamamoto, Yoshihiko Seino, kyoichi Mizuno
    • Organizer
      第74回日本循環器学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Recurrent Restenosis of Sirolimus-Eluting Stent Implantation for Paclitaxel-Eluting Stent Restenosis : different Abnormal Findings of Optical Coherence Tomography2010

    • Author(s)
      Masanori Yamamoto
    • Organizer
      Complex Cardiovascular Therapeutics 2010
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2010-01-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] OCT findings of DES follow-Up : Comarison with coronary angioscopy2010

    • Author(s)
      Masamichi Takano
    • Organizer
      Complex Cardiovascular Therapeutics 2010
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2010-01-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Elevation of soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009

    • Author(s)
      Yamamoto M, Seino Y, Okamatsu K, Inami T, Murakami D, Ohba T, Aoki S, Ibuki C, Takano M, Mizuno K, Hata N
    • Organizer
      American Heart Association Scientific Session 2009
    • Place of Presentation
      米国, Orlando
    • Year and Date
      2009-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Link of Sleep Apnea Syndrome to Coronary Atherosclerotic Burden and Elevated Cardiac Biomarkers in Stable Coronary Artery Disease Patients2009

    • Author(s)
      Inami T, Seino Y, Yamamoto M, Kimata N, Murakami D, Takano M, Ohba T, Aoki S, Ibuki C, Mizuno K
    • Organizer
      American Heart Association Scientific Session 2009
    • Place of Presentation
      米国, Orlando
    • Year and Date
      2009-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Elevation of soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels After Plaque Disruption2009

    • Author(s)
      Masanori Yamamoto, Yoshihiko Seino, et al
    • Organizer
      American Heart Association Scientific Meeting 2009
    • Place of Presentation
      Orlando, U.S.A
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Link of Sleep Apnea Syndrome to Coronary Atherosclerotic Burden and Elevated Cardiac Biomarkers in Stable Coronary Artery Disease Patient2009

    • Author(s)
      Toru Inami
    • Organizer
      American Heart Association Scientific Meeting 2009
    • Place of Presentation
      Orlando, U.S.A
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 安定冠動脈疾患における睡眠時無呼吸症候群と冠動脈病変形成および心筋バイオマーカーの関連性2009

    • Author(s)
      稲見徹,清野精彦,山本真功,木股仲恒,村上大介,大場崇芳,青木聡
    • Organizer
      第57回日本心臓病学会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 安定冠動脈疾患における睡眠時無呼吸症候群と冠動脈病変形成および心筋バイオマーカーの関連性2009

    • Author(s)
      稲見徹、清野精彦, 他7名
    • Organizer
      第57回日本心臓病学会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 冠動脈疾患に対する先端画像とマルチバイオマーカー・ストラテジー2009

    • Author(s)
      清野精彦
    • Organizer
      第20回日本臨床化学学会東海・北陸支部総会
    • Place of Presentation
      名古屋国際会議場(教育講演)
    • Year and Date
      2009-08-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 冠動脈疾患に対する先端画像とマルチバイオマーカー・ストラテジー2009

    • Author(s)
      清野精彦
    • Organizer
      第20回日本臨床化学学会東海・北陸支部総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-08-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] OCT画像における残存血液が与える影響2009

    • Author(s)
      水野正之、高野雅充, 他3名
    • Organizer
      第18回日本心血管インターベンション治療学会
    • Place of Presentation
      ロイトン札幌 (札幌)
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of bi-edge late restenotic lesions in a sirolimus-eluting steneluting stent case by coronary angioscopy and OCT2009

    • Author(s)
      Toru Inami, Masamichi Takano, et al.
    • Organizer
      第18回日本心血管インターベンション治療学会
    • Place of Presentation
      ロイトン札幌(札幌)札幌
    • Year and Date
      2009-06-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Minute Myocardial Injury Detected by High -Sensitivity Troponin T Measurement in Stable Coronary Artery Disease Patients significant link to NT-proBNP Elevation.2009

    • Author(s)
      Kimata N, Seino Y, Yamamoto M, Inami S, Murakami D, Tara S, et al 他
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Minute Myocardial Injury Detected by High-Sensitivity Troponin T Measurement in Stable Coronary Artery Disease Patients : significant link to NT-proBNP Elevation2009

    • Author(s)
      Nakahisa Kimata, et al.
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪国際会議場(ポスター会場4)
    • Year and Date
      2009-03-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Even Mild Elevation of sLOX-1 may Reflect Coronary Atherose- clerotic Plaque Burden in Non-AMI Coronary Artery Disease Patients2009

    • Author(s)
      Inami T, Yamamoto M, Kimata N, Okada K, Tara S, Murakami D, Tajika K, Ohba T, Aoki S, Ibuki C, Yohoyama S, Hata N, Takano M, Seino Y
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Even Mild Elevation of sLOX-1 may Reflect Coronary Atheroseclerotic Plaque Burden in Non-AMI Coronary Artery Disease Patients.2009

    • Author(s)
      Toru Inami, et al.
    • Organizer
      第73回日本循環器学会
    • Place of Presentation
      大阪国際会議場(第5会場)
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Book] Annual Review循環器(1)2011

    • Author(s)
      清野精彦
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review循環器2010

    • Author(s)
      清野精彦
    • Total Pages
      8
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 別冊医学のあゆみ特集号心血管マルチバイオマーカー・ストラテジー(1)2009

    • Author(s)
      清野精彦
    • Total Pages
      122
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 医学のあゆみ特集号 心血管マルチバイオマーカー・ストラテジー2008

    • Author(s)
      清野精彦
    • Total Pages
      111
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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