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Association of plasma S100A12 level with cardiovascular diseases.

Research Project

Project/Area Number 20590846
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKansai Medical University

Principal Investigator

KOSAKI Atsushi  関西医科大学, 医学部, 講師 (40330188)

Co-Investigator(Kenkyū-buntansha) MORI Yasukiyo  京都府立医科大学, 医学研究科, 准教授 (40268371)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords動脈硬化 / 心血管イベント / 慢性腎臓病 / S100A12 / S100A12タンパク質 / 糖尿病 / 糖尿病性腎症
Research Abstract

In end stage renal disease(ESRD) patients, we found that mean plasma S100A12 level was 2.3-fold higher than that in control subjects and that this level was an independent factorassociated with the prevalence of atherosclerotic cardiovascular diseases(CVD) such as ischemic heart disease including myocardial infarction and angina pectoris, symptomatic stroke and symptomatic peripheral vascular disease. Therefore, we anticipate an important role for S100A12 as a novel biomarker to predict CVD in patients with ESRD. Prospective and interventional studies are currently ongoing to further elucidate the relationship between plasma S100A12 level and CVD.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (8 results)

  • [Journal Article] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease2011

    • Author(s)
      Shiotsu Y, Mori Y, Hatta T, Maki N, Iida K, Matsuoka E, Kado H, Ishida R, Kishimoto N, TamagakiK, Nishimura M, Iwamoto N, Ono T, Matsubara H, Kosaki A.
    • Journal Title

      Nephron Extra

      Volume: 1 Pages: 242-250

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients2011

    • Author(s)
      Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, HattaT, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A
    • Journal Title

      Clin. J. Am. Soc. Nephrol.

      Volume: 6 Pages: 718-723

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 levels and peripheral arterial disease in end-stase renal disease2011

    • Author(s)
      Yayoi Shiotsu, 等
    • Journal Title

      Nephron Extra

      Volume: 1 Issue: 1 Pages: 242-250

    • DOI

      10.1159/000335198

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients2011

    • Author(s)
      Yayoi Shiotsu, 等
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 6 Issue: 4 Pages: 718-723

    • DOI

      10.2215/cjn.08310910

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients.2011

    • Author(s)
      Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, Hatta T, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A
    • Journal Title

      Clin.J.Am.Soc.Nephrol. 6

      Pages: 718-723

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Increased plasma S100A12(EN-RAGE) levels in hemodialysis patients with atherosclerosis2009

    • Author(s)
      Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, Nakajima F, Nagahara M, Urakami M, Iwasaka T, Matsubara H
    • Journal Title

      Am. J. Nephrol.

      Volume: 29 Pages: 18-24

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased plasma S100A12 (EN-RAGE) levels in hemodialysis patients with atherosclerosis.2009

    • Author(s)
      Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, Nakajima F, Nagahara M, Urakami M, Iwasaka T, Matsubara H
    • Journal Title

      Am.J.Nephrol. 29

      Pages: 18-24

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Increased plasma S100A12(EN-RAGE)levels in hemodialysis patients with atherosclerosis2009

    • Author(s)
      Mori Yasukiyo
    • Journal Title

      Am J Nephrol 29

      Pages: 18-24

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased plasma S100A12 (EN-RAGE) levels in hemodialysis patients with atherosclerosis.2009

    • Author(s)
      Mori Yasukiyo
    • Journal Title

      Am J Nephrol 29

      Pages: 18-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 concentrations in peritoneal dialysis patients and subclinical chronic inflammatory disease.2008

    • Author(s)
      Uchiyama-Tanaka, Y.
    • Journal Title

      Ther Apher Dial 12

      Pages: 28-32

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease2011

    • Author(s)
      Mori Y, Shiotsu Y, Matsuoka E, Kosaki A
    • Organizer
      ASN's Annual Renal Week Meeting 2011
    • Place of Presentation
      Philadelphia, PA. USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease2011

    • Author(s)
      Yasukiyo Mori
    • Organizer
      ASN's Annual Renal Week Meeting 2011
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases in non-diabetic hemodialysis patients2010

    • Author(s)
      Mori Y, Shiotsu Y, Kosaki A
    • Organizer
      ASN's Annual Renal Week Meeting 2010
    • Place of Presentation
      Denver, Co. USA
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases in non-diabetic hemodialysis patients.2010

    • Author(s)
      Mori Y, Shiotsu Y, Kosaki A
    • Organizer
      ASN's Annual Renal Week Meeting 2010
    • Place of Presentation
      Denver, Co.USA
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] 血中S100A12タンパク質の動脈硬化性血管障害イベントへの関与に関する研究2010

    • Author(s)
      小崎篤志、森泰清
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-05-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases inhemodialysis patients2009

    • Author(s)
      Mori Y, Shiotsu Y, Nishimura M, Hatta T, Maki N, Iida K, Matsubara H, Kosaki A
    • Organizer
      ASN's Annual Renal Week Meeting 2009
    • Place of Presentation
      San Diego, CA. USA
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases in hemodialysis patients.2009

    • Author(s)
      Mori Y, Shiotsu Y, Nishimura M, Hatta T, Maki N, Iida K, Matsubara H, Kosaki A
    • Organizer
      ASN's Annual Renal Week Meeting 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-10-30
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Increased plasma S100A12 level is associated with cardiovascular diseases in hemodialysis patients2009

    • Author(s)
      Yayoi Shiotsu
    • Organizer
      ASN's Annual Renal Week Meeting 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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