Association of plasma S100A12 level with cardiovascular diseases.
Project/Area Number |
20590846
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kansai Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MORI Yasukiyo 京都府立医科大学, 医学研究科, 准教授 (40268371)
|
Project Period (FY) |
2008 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 動脈硬化 / 心血管イベント / 慢性腎臓病 / S100A12 / S100A12タンパク質 / 糖尿病 / 糖尿病性腎症 |
Research Abstract |
In end stage renal disease(ESRD) patients, we found that mean plasma S100A12 level was 2.3-fold higher than that in control subjects and that this level was an independent factorassociated with the prevalence of atherosclerotic cardiovascular diseases(CVD) such as ischemic heart disease including myocardial infarction and angina pectoris, symptomatic stroke and symptomatic peripheral vascular disease. Therefore, we anticipate an important role for S100A12 as a novel biomarker to predict CVD in patients with ESRD. Prospective and interventional studies are currently ongoing to further elucidate the relationship between plasma S100A12 level and CVD.
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease2011
Author(s)
Shiotsu Y, Mori Y, Hatta T, Maki N, Iida K, Matsuoka E, Kado H, Ishida R, Kishimoto N, TamagakiK, Nishimura M, Iwamoto N, Ono T, Matsubara H, Kosaki A.
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Journal Title
Nephron Extra
Volume: 1
Pages: 242-250
Related Report
Peer Reviewed
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[Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients2011
Author(s)
Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, HattaT, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A
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Journal Title
Clin. J. Am. Soc. Nephrol.
Volume: 6
Pages: 718-723
Related Report
Peer Reviewed
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[Journal Article] Plasma S100A12 level is associated with cardiovascular disease in hemodialysis patients.2011
Author(s)
Shiotsu Y, Mori Y, Nishimura M, Sakoda C, Tokoro T, Hatta T, Maki N, Iida K, Iwamoto N, Ono T, Matsuoka E, Kishimoto N, Tamagaki K, Matsubara H, Kosaki A
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Journal Title
Clin.J.Am.Soc.Nephrol. 6
Pages: 718-723
Related Report
Peer Reviewed
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[Journal Article] Increased plasma S100A12(EN-RAGE) levels in hemodialysis patients with atherosclerosis2009
Author(s)
Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, Nakajima F, Nagahara M, Urakami M, Iwasaka T, Matsubara H
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Journal Title
Am. J. Nephrol.
Volume: 29
Pages: 18-24
Related Report
Peer Reviewed
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[Journal Article] Increased plasma S100A12 (EN-RAGE) levels in hemodialysis patients with atherosclerosis.2009
Author(s)
Mori Y, Kosaki A, Kishimoto N, Kimura T, Iida K, Fukui M, Nakajima F, Nagahara M, Urakami M, Iwasaka T, Matsubara H
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Journal Title
Am.J.Nephrol. 29
Pages: 18-24
Related Report
Peer Reviewed
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