| Project/Area Number |
20590848
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
KAWAMOTO Takahiro Kawasaki Medical School, 医学部, 講師 (30368667)
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| Co-Investigator(Kenkyū-buntansha) |
OKURA Hiroyuki 川崎医科大学, 医学部, 准教授 (30425136)
NEISHI Yoji 川崎医科大学, 医学部, 講師 (80319946)
TSUCHIYA Tetsuo 川崎医科大学, 医学部, 助教 (80388959)
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| Research Collaborator |
NEZUO Shintaro 川崎医科大学, 医学部, 助教 (10412173)
MAEHAMA Tomoko 川崎医科大学, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 一酸化窒素 / 血管内皮機能 / メタボリック症候群 / 心血管イベント / 動物実験 / メタボリック症侯群 / 冠循環 / 内皮機能 / インスリン抵抗性 |
|---|
| Research Abstract |
We evaluated the endothelial dependent nitric oxide production in a canine model of metabolic syndrome induced by high fat diets and we demonstrated that the endothelium-dependent nitric oxide production was diminished according to the deterioration of insulin resistance. However, drug induced maximal hyperemia of coronary microcirculation was maintained in a same model, so it was possible that in case of the elimination of nitric oxide bioavailability, coronary vasodilatation was maintained by other vasoactive factors, such as adenosine or prostaglandin. We also evaluated the optimal value of the cuff pressure and the ischemic time at measurement of the flow mediated vasodilatation response of human forearm and demonstrated that resting blood pressure plus 30 mmHg and 5 minutes were optimal.
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