Development of intracoronary imaging system to predict and stabilize unstable coronary plaque

• Project/Area Number: 20590849
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: OKURA Hiroyuki Kawasaki Medical School, 医学部, 准教授 (30425136)
• Co-Investigator(Kenkyū-buntansha): KAWAMOTO Takahiro 川崎医科大学, 医学部, 講師 (30368667) ; NEISHI Yoji 川崎医科大学, 医学部, 講師 (80319946) ; YOSHIDA Kiyoshi 川崎医科大学, 医学部, 教授 (60322583)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 冠動脈 / 不安定プラーク / 血管内超音波 / 光干渉断層法 / 虚血性心疾患 / 動脈硬化 / 血管内光干渉断層法 / 急性冠症候群 / 糖尿病

Research Abstract

To investigate plaque characteristics and serial changes in coronary arterial plaque of unstable or vulnerable plaque, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging were performed in patient with coronary artery disease. IVUS-derived tissue characterization revealed that predominant plaque component of the thin-cap fibroatheroma was lipid pool. In addition, positive arterial remodeling contributed to progressive thinning of the fibrous cap.

Research Products

• [Journal Article] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound. (2011)
  • Author(s): Miyamoto Y, Okura H, Kume T, Kawamoto T, Neishi Y, Hayashida A, Yamada R, Imai K, Saito K, Yoshida K
  • Journal Title: JACC Cardiovasc Img (in press)
  • Peer Reviewed
• [Journal Article] Plaque characteristics of thin cap fibroatheroma evaluated by optical coherence tomography and integrated backscatter intravascular ultrasound (2011)
  • Author(s): Miyamoto Y, Okura H, Kawamoto T, Neishi Y, Yoshida K, et al.
  • Journal Title: JACC Cardiovascular Imaging Volume: (in press)
  • Peer Reviewed
• [Journal Article] Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study. (2010)
  • Author(s): Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Imai K, Tsuchiya T, Maehama T, Okahashi N, Obase K, Hayashida A, Neishi Y, Kawamoto T, Yoshida K
  • Journal Title: Circ Cardiovasc Intervent Vol.3, No.2 Pages: 484-490
  • Peer Reviewed
• [Journal Article] Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study (2010)
  • Author(s): Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Hayashida A, Yoshida K, et al.
  • Journal Title: Circulation : Cardiovascular Interventions Volume: 3(5) Pages: 484-90
  • Peer Reviewed
• [Presentation] Arterial Remodeling And Coronary Plaque Compositions : An In Vivo Tissue Characterization using Integrated Backscatter-intravascular Ultrasound. (2010)
  • Author(s): Miyamoto Y, Okura H, Yoshida K, et al.
  • Organizer: Scientific Sessions 2010, American Heart Association
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2010-11-14
• [Presentation] Arterial remodeling and coronary plaque compositions : an in vivo tissue characterization using integrated backscatter-intravagsular ultrasound (2010)
  • Author(s): Miyamoto Y, Okura H, Yoshida K, et al.
  • Organizer: American Heart Association
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2010-11-14
• [Presentation] 脂質低下療法による線維性被膜の経時的変化:スタンダードスタチンとストロングスタチンの比較 (2010)
  • Author(s): 山田亮太郎、大倉宏之、宮本欣倫、根石陽二、土谷哲生、川元隆弘、林田晃弘、吉田清
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-19
• [Presentation] Changes in Fibrous Cap Thickness in Diabetic and Non-diabetic Patients : A Serial Optical Coherence Tomography Study. (2010)
  • Author(s): 山田亮太郎、大倉宏之、根石陽二、川元隆弘、吉田清, ほか
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Changes in Fibrous Cap Thickness in Diabetic and Non-diabetic Patients : A Serial Optical Coherence Tomography Study (2010)
  • Author(s): Yamada R, Okura H, Yoshida K, et al.
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-03-05
• [Presentation] 光干渉断層法とintegrated backscatter intravascular ultrasound によるthin cap fibroaheromaの診断. (2009)
  • Author(s): 宮本欣倫、大倉宏之、根石陽二、川元隆弘、吉田清, ほか
  • Organizer: 第57回日本心臓病学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-19
• [Presentation] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Back scatter Intravascular Ultrasound (2009)
  • Author(s): Miyamoto Y, Okura H, Yoshida K, et al.
  • Organizer: American College of Cardiology
  • Place of Presentation: オーランド、米国
  • Year and Date: 2009-03-30
• [Presentation] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound. (2009)
  • Author(s): Miyamoto Y, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
  • Organizer: Scientific Sessions 2009, American College of Cardiology
  • Place of Presentation: オーランド、米国
  • Year and Date: 2009-03-29
• [Presentation] Relationship between the change of fibrous cap thickness and plaque morphology : six months follow-up study of optical coherence tomography and intravascular ultrasound. (2009)
  • Author(s): Yamada R, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
  • Organizer: Scientific Sessions 2009, American College of Cardiology
  • Place of Presentation: オーランド、米国
  • Year and Date: 2009-03-29
• [Presentation] Relationship between the change of fibrous cap thickness and plaque morphology : Six months follow-up study of optical coherence tomography. (2009)
  • Author(s): Yamada R, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Remarks] ホームページ等