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Immunomodulationtherapyagainstdilatedcardiomyopathy

Research Project

Project/Area Number 20590852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKitasato University

Principal Investigator

BABA Akiyasu  Kitasato University, 北里研究所病院, 研究員 (60296572)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords拡張型心筋症 / 免疫吸着療法 / 心筋自己抗体
Research Abstract

Some DCM (dilated cardiomyopathy) patients have autoantibodies against their heart, which we can remove from the body by immunoadsorption therapy. This study discovered a characteristic of the patient whom this therapy worked for well. When we completely removed autoantibodies from the body by this treatment, the cardiac function get better. Even if autoantibodies increase again in the body, and the cardiac function reverses, we may perform the immunoadsorption many times.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (54 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 6 results) Presentation (25 results) Book (4 results) Remarks (4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Specific immunoadsorption therapy using a tryptophan column in patients with refractory heart failure due to dilated cardiomyopathy.2011

    • Author(s)
      Nagatomo Y, Baba A, et al.
    • Journal Title

      J Clin Apher 26(1)

      Pages: 1-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Specific immunoadsorption therapy using a tryptophan column in patients with refractory heart failure due to dilated cardiomyopathy.2011

    • Author(s)
      Nagatomo Y, Baba A, et al
    • Journal Title

      J Clin Apher

      Volume: 26(1) Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete elimination of cardiodepressant IgG3 autoantibodies by immunoadsorption in patients with severe heart failure.2010

    • Author(s)
      馬場彰泰, et al.
    • Journal Title

      Circ J 74

      Pages: 1372-1378

    • NAID

      10030695502

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【心不全 研究と臨床の最前線】心不全の治療【非薬物治療】重症拡張型心筋症に対する免疫吸着療法2010

    • Author(s)
      吉川勉,長友祐司,馬場彰泰
    • Journal Title

      医学のあゆみ 232

      Pages: 544-547

    • Related Report
      2010 Final Research Report
  • [Journal Article] Complete elimination of cardiodepressant IgG3 autoantibodies by immunoadsorption in patients with severe heart failure2010

    • Author(s)
      Baba A, et al.
    • Journal Title

      Circ J (in press 未定)

    • NAID

      10030695502

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【心不全 研究と臨床の最前線】心不全の治療【非薬物治療】重症拡張型心筋症に対する免疫吸着療法2010

    • Author(s)
      吉川勉, 長友祐司, 馬場彰泰
    • Journal Title

      医学のあゆみ 232

      Pages: 544-547

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Autoimmune mechanisms underlying dilated cardiomyopathy.2009

    • Author(s)
      Yoshikawa T, Baba A, Nagatomo Y
    • Journal Title

      Circ J 73

      Pages: 602-607

    • NAID

      10025928808

    • Related Report
      2010 Final Research Report
  • [Journal Article] A pilot study on the role of autoantibody targeting the betal-adrenergic receptor in the response to beta-blocker therapy for congestive heart failure.2009

    • Author(s)
      Nagatomo Y, Yoshikawa T, Kohno T, Yoshizawa A, Baba A, et al.
    • Journal Title

      J Card Fail 15

      Pages: 224-232

    • Related Report
      2010 Final Research Report
  • [Journal Article] 免疫吸着療法とピモベンダン少量分割投与が有用であった拡張型心筋症の一例2009

    • Author(s)
      馬場彰泰, ら
    • Journal Title

      診療と新薬 46

      Pages: 795-798

    • Related Report
      2010 Final Research Report
  • [Journal Article] 拡張型心筋症に対して免疫吸着療法が著効を示した1例2009

    • Author(s)
      森田弘之,馬場彰泰, ら
    • Journal Title

      日本アフェレシス学会雑誌 28

      Pages: 167-179

    • Related Report
      2010 Final Research Report
  • [Journal Article] A pilot study on the role of autoantibody targeting the beta1-adrenergic receptor in the response to beta-blocker therapy for congestive heart failure.2009

    • Author(s)
      Nagatomo Y, Yoshikawa T, Kohno T, Yoshizawa A, Baba A, et al
    • Journal Title

      J Card Fail 15

      Pages: 224-232

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmune mechanisms underlying dilated cardiomyopathy.2009

    • Author(s)
      Yoshikawa T, Baba A, Nagatomo Y.
    • Journal Title

      Circ J 73

      Pages: 602-607

    • NAID

      10025928808

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫吸着療法とピモベンダン少量分割投与が有用であった拡張型心筋症の一例2009

    • Author(s)
      馬場彰泰, 島田恵, 高橋路子, 赤石誠
    • Journal Title

      診療と新薬 46

      Pages: 795-798

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 拡張型心筋症に対して免疫吸着療法が著効を示した1例2009

    • Author(s)
      森田弘之, 馬場彰泰, ら
    • Journal Title

      日本アフェレシス学会雑誌 28

      Pages: 167-170

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies in atrial fibrillation : actor, biomarker or bystander?2008

    • Author(s)
      Baba A, Fu M
    • Journal Title

      Autoimmunity 41

      Pages: 470-472

    • Related Report
      2010 Final Research Report
  • [Journal Article] 拡張型心筋症の免疫吸着療法2008

    • Author(s)
      馬場彰泰
    • Journal Title

      呼吸と循環 56

      Pages: 371-375

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] Autoantibodies in atrial fibrillation : actor, biomarker or bystander?2008

    • Author(s)
      Baba A, Fu M.
    • Journal Title

      Autoimmunity 41

      Pages: 470-472

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 井上学術奨励賞受賞記念講演「心不全アフェレシスに関する検討」2010

    • Author(s)
      馬場彰泰
    • Organizer
      第31回日本アフェレシス学会学術集会
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ワークショップ7透析患者の心不全を考える「抗心筋抗体と透析患者の心不全」2010

    • Author(s)
      馬場彰泰, ら
    • Organizer
      第55回日本透析医学会学術集会
    • Year and Date
      2010-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] ワークショップ7 透析患者の心不全を考える「抗心筋抗体と透析患者の心不全」2010

    • Author(s)
      馬場彰泰、清元秀泰、緒方浩顕、杉本徳一郎
    • Organizer
      第55回日本透析医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心不全のアフェレシス2010

    • Author(s)
      馬場彰泰
    • Organizer
      第47回山梨小児循環器懇話会
    • Place of Presentation
      招待講演
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 心不全のアフェレシス(招待講演)2010

    • Author(s)
      馬場彰泰
    • Organizer
      第47回山梨小児循環器懇話会
    • Place of Presentation
      甲府
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anti-myocardial autoantibodies in hemodialysis patients.2010

    • Author(s)
      Rokumaru Y, Baba A, et al.
    • Organizer
      第74回日本循環器学会学術大会
    • Year and Date
      2010-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Anti-myocardial autoantibodies in hemodialysis patients2010

    • Author(s)
      Yuri Rokumaru, Akiyasu Baba, Makoto Akaishi, Megumi Shimada
    • Organizer
      第74回日本循環器学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Specific immunoadsorption therapy using a new tryptophan column in patients with refractroy heart failure due to dilated cardiomyopathy2010

    • Author(s)
      Yoshikawa T, Nagatomo Y, Baba A, et al.
    • Organizer
      第74回日本循環器学会学術大会
    • Place of Presentation
      パネルディスカッション
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Specific immunoadsorption therapy using a new tryptophan column in patients with refractroy heart failure due to dilated cardiomyopathy(パネルディスカッション)2010

    • Author(s)
      Tsutomu Yoshikawa, Yuji Nagatomo, Akihiro Yoshizawa, Yasuo Kurita, Satoshi Ogawa, Iwao Nakamura, Toshiaki Monkawa, Takashi Matsubara, Yasuhisa Wakabayashi, Makoto Akaishi, Akiyasu Baba
    • Organizer
      第74回日本循環器学会総会・学術大会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 拡張型心筋症に対する免疫吸着療法の安全性・有効性の検討2009

    • Author(s)
      門川俊明,馬場彰泰, ら
    • Organizer
      第28回日本アフェレシス学会関西地方会
    • Place of Presentation
      特別講演
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 拡張型心筋症に対する免疫吸着療法の安全性・有効性の検討(特別講演)2009

    • Author(s)
      門川俊明、林松彦、長友祐司、馬場彰泰、吉川勉
    • Organizer
      第28回日本アフェレシス学会 関西地方会
    • Place of Presentation
      金沢
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性心不全の治療ガイドラインを検証する:慢性心不全患者におけるβ遮断薬有効性の個体差:βアドレナリン受容体抗体を指標とした解析2009

    • Author(s)
      吉川勉,長友祐司,馬場彰泰, ら
    • Organizer
      第57回日本心臓病学会学術集会
    • Year and Date
      2009-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性心不全の治療ガイドラインを検証する:慢性心不全患者におけるβ遮断薬有効性の個体差:βアドレナリン受容体抗体を指標とした解析2009

    • Author(s)
      吉川勉、長友祐司、河野隆志、吉澤彰宏、馬場彰泰、安斉俊久、目黒知己、佐藤徹、小川聡
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 透析患者における液性免疫異常の検討2009

    • Author(s)
      六丸友里,馬場彰泰, ら
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Year and Date
      2009-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 透析患者における液性免疫異常の検討2009

    • Author(s)
      六丸友里、馬場彰泰、露崎薫、厚田幸一郎、清元秀泰、緒方浩顕
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓血管病のアフェレシス治療:重症拡張型心筋症に対するトリプトファンカラムを用いた免疫吸着療法2009

    • Author(s)
      長友祐司,馬場彰泰, ら
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 炎症性腸疾患を合併した拡張型心筋症に対して血漿交換療法を行った1例2009

    • Author(s)
      村山章,馬場彰泰, ら
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 心臓血管病のアフェレシス治療:重症拡張型心筋症に対するトリプトファンカラムを用いた免疫吸着療法2009

    • Author(s)
      長友祐司、馬場彰泰、伊藤博之、内藤広太郎、吉澤彰宏、栗田康生、中村岩男、門川俊明、松原隆、若林靖久、小川聡、赤石誠、吉川勉
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性腸疾患を合併した拡張型心筋症に対して血漿交換療法を行った1例2009

    • Author(s)
      村山章、馬場彰泰、渡辺憲明、島田恵、赤石誠、若林靖久
    • Organizer
      第30回日本アフェレシス学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 透析患者における抗M2ムスカリン受容体抗体2009

    • Author(s)
      六丸友理,馬場彰泰
    • Organizer
      第18回日本アフェレシス学会関東甲信越地方会
    • Year and Date
      2009-04-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 透析患者における抗M2ムスカリン受容体抗体2009

    • Author(s)
      六丸友理、馬場彰泰、露崎薫、厚田幸一郎、緒方浩顕
    • Organizer
      第18回日本アフェレシス学会関東甲信越地方会
    • Place of Presentation
      柏
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 拡張型心筋症に対する免疫吸着療法2009

    • Author(s)
      馬場彰泰
    • Organizer
      第5回長野県重症心不全研究会
    • Place of Presentation
      招待講演
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 拡張型心筋症に対する免疫吸着療法(招待講演)2009

    • Author(s)
      馬場彰泰
    • Organizer
      第5回長野県重症心不全研究会
    • Place of Presentation
      松本
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Therapeutic apheresis in Japan at the front : Cardiodepressant IgG3 autoantibody elimination by immunoadsorption in patients with dilated cardiomyopathy.2009

    • Author(s)
      馬場彰泰
    • Organizer
      #12 World apheresis association Meeting.
    • Year and Date
      2009-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Therapeutic apheresis in Japan at the front : Cardiodepressant IgG3 autoantibody elimination by immunoadsorption in patients with dilated cardiomyopathy.2009

    • Author(s)
      Akiyasu Baba
    • Organizer
      #12 World apheresis association Meeting
    • Place of Presentation
      アルゼンチン、ブエノスアイレス
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Book] アフェレシスマニュアル改訂第3版(クリニカルエンジニアリング別冊) 臨床編III-4-b.拡張型心筋症2010

    • Author(s)
      馬場彰泰(分担)
    • Publisher
      秀潤社
    • Related Report
      2010 Annual Research Report
  • [Book] 【血液浄化療法2009】血液浄化のトピックス 心筋症とアフェレシス2009

    • Author(s)
      馬場彰泰
    • Total Pages
      3
    • Publisher
      東京医学社
    • Related Report
      2009 Annual Research Report
  • [Book] 血液浄化療法2009(心筋症とアフェレシス(血液浄化のトピックス))2008

    • Author(s)
      馬場彰泰
    • Total Pages
      752
    • Publisher
      東京医学社
    • Related Report
      2010 Final Research Report
  • [Book] 拡張型心筋症(アフェレシスマニュアル改訂第3版(クリニカルエンジニアリング別冊)臨床編III-4-b)

    • Author(s)
      馬場彰泰
    • Publisher
      秀潤社
    • Related Report
      2010 Final Research Report
  • [Remarks] 日本心臓移植研究 HP、2008年学術報告「拡張型心筋症による重症心不全に対する免疫吸着療法」

    • URL

      http://www.med.osaka-u.ac.jp/pub/surg1/JSHT/report/img/report0812.pdf

    • Related Report
      2010 Final Research Report
  • [Remarks] 読売新聞[夕刊企画]免疫吸着療法拡張型心筋症に効果

    • URL

      http://www.yomidr.yomiuri.co.jp/page.jsp?id=21606

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.kitasato-u.ac.jp/hokken-hp/consultation/guide/diagnosis/circulation/immunoadsorption.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kitasatou.ac.jp/hokken.hp/consultation/guide/diagnosis/circulation/immunoadsorption.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] Methods for Predicting Effectiveness of Apheresis Therapy for Heart Failure2010

    • Inventor(s)
      Akiyasu Baba
    • Industrial Property Rights Holder
      Kitasato In stitute
    • Filing Date
      2010
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 心不全アフェレシス治療の効果の予測方法2009

    • Inventor(s)
      馬場彰泰
    • Industrial Property Rights Holder
      北里大学
    • Industrial Property Number
      2008-218033
    • Filing Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心不全アフェレーシス治療の効果の予測方法(Methods for Predicting Effectiveness of Apheresis Therapy for Heart Failure)2008

    • Inventor(s)
      馬場彰泰
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2008-08-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 心不全アフェレーシス治療の効果の予測方法(Methods for Predicting Effectiveness of Apheresis Therapy for Heart Failure)2008

    • Inventor(s)
      馬場彰泰
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2008-08-27
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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