| Project/Area Number |
20590853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Kochi University |
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Principal Investigator |
ZHENG Can Kochi University, 教育研究部・医療学系, 助教 (50443495)
|
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| Co-Investigator(Renkei-kenkyūsha) |
LI Meihua 国立循環器病センター(研究所), 循環動態機能部, 特任研究員 (60443496)
KAWADA Toru 国立循環器病センター(研究所), 循環動態機能部, 室長 (30243752)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 迷走神経刺激 / 特発拡張型心筋症 / 自己免疫 / 心筋症 / 迷走神経 / 電気刺激 / 神経電気刺激 / 心機能 |
|---|
| Research Abstract |
Myocarditis is an inflammatory heart disease, considered as one of the main causes of dilated cardiomyopathy, a fatal heart disease. Current therapeutic strategy is focus on the anti-inflammatory and nosotropic treatments by pharmaceutics. In this study, we hypothesis and verified that vagal nerve stimulation may exert beneficial effects on cardiac inflammation and demonstrated that vagal stimulation attenuates ventricle remodeling and improve survival after myocardial infarction, which may be associated with suppression of acute inflammatory reactions.
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