Study on the molecular mechanisms and treatment for the impaired exercise capacity in metabolic syndrome
| Project/Area Number |
20590854
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KINUGAWA Shintaro Hokkaido University, 大学院・医学研究科, 助教 (60399871)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Hiroyuki 北海道大学, 大学院・医学研究科, 教授 (70264017)
FURUMOTO Tomoo 北海道大学, 大学院・医学研究科, 特任助教 (10399925)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKITA Koichi 北翔大学, 大学院・生涯学習研究科, 教授 (80382539)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | メタボリックシンドローム / 運動能力 / 酸化ストレス / ミトコンドリア機能 / 骨格筋 / 小動物用トレッドミル |
|---|
| Research Abstract |
The exercise capacity was impaired in metabolic syndrome mice, which was associated with mitochondrial dysfunction in the skeletal muscle. Furthermore, NAD (P) H oxidase-dependent oxidative stress in skeletal muscle played an important role in the impaired exercise capacity and mitochondrial dysfunction. The present study demonstrated that therapies designed to regulate oxidative stress and maintain mitochondrial function could be beneficial to improve the exercise capacity in metabolic syndrome.
|
Report
(4 results)
Research Products
(29 results)
-
-
-
-
-
-
-
[Journal Article] Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice.2009
Author(s)
Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H
-
Journal Title
Am J Physiol Heart Circ Physiol 297
Pages: 1069-1077
Related Report
Peer Reviewed
-
[Journal Article] Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction.2009
Author(s)
Suga T, Okita K, Morita N, Yokota T, Hirabayashi K, Horiuchi M, Takada S, Takahashi T, Omokawa M, Kinugawa S, Tsutsui H
-
Journal Title
J Appl Physiol 106
Pages: 1119-24
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] Pioglitazone increases the aerobic capacity with improved skeletal muscle energetics in patients with insulin resistance.2010
Author(s)
Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Takahashi M, Ono T, Sobirin AM, Okita K, Tsutsui H
Organizer
European Association for the Study of Diabetes 2010
Place of Presentation
Stockholm, Sweden
Year and Date
2010-09-21
Related Report
-
-
-
-
-
-
[Presentation] Pioglitazone improves aerobic capacity and skeletal muscle high-energy phosphate metabolism in patients with metabolic syndrome.2009
Author(s)
Yokota T, Kinugawa S, Hirabayashi K, Suga T, Matsushima S, Sobirin AM, Ono T, Morita N, Takada S, Omokawa M, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Sessions 2009
Place of Presentation
Orlando, USA
Year and Date
2009-11-18
Related Report
-
-
-
-
-
-
-
-
