Arrhythmogenic mechanism of gap junctional uncoupling
| Project/Area Number |
20590860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
HONJO Haruo Nagoya University, 環境医学研究所, 准教授 (70262912)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Kaichiro 名古屋大学, 環境医学研究所, 教授 (50194973)
TSUJI Yukiomi 名古屋大学, 環境医学研究所, 助教 (60432217)
KODAMA Itsuo 名古屋大学, 環境医学研究所, 名誉教授 (30124720)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ギャップ接合 / 致死性不整脈 / スパイラルリエントリー / 光学マッピング / 活動電位 / 興奮伝播 / スパイラル・リエントリー / 興奮伝導 / 湾曲効果 / 電気生理学 / 不整脈 / 空間定数 / 拡散係数 / リエントリー |
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| Research Abstract |
Arrhythmogenic mechanisms of intercellular electrical uncoupling was investigated by optical mapping of purfued rabbit hearts. Pharmacological inhibition of myocardial gap junctions stabilized the dynamics of spiral-wave reentry and facilitated its perpetuation, whereas enhancement of gap junctional coupling destabilized spiral-wave reentry and promoted its early self-termination by compromising propagation of excitation waves with strong curvature near the rotation center. These results suggest that enhancement of gap junctional coupling could be a useful strategy for the treatment of life-threatening arrhythmias in diseased hearts with gap junctional remodeling.
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Report
(4 results)
Research Products
(42 results)
