Identification and characterization of proteins bound to MURC which is involved in cardiac dysfunction and arrhythmia
Project/Area Number |
20590863
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
UEYAMA Tomomi Kyoto Prefectural University of Medicine, 医学研究科, 講師 (80379388)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 心不全 / 不整脈 / 筋特異的遺伝子 / 結合蛋白質 / MURC |
Research Abstract |
We found that MURC was localized to caveolae at the plasma membrane of cardiomyocytes, and that MURC was associated with caveolin-3, PTRF/cavin-1, SDPR/cavin-2, and SRBC/cavin-3. We also found that overexpression of MURC in cardiomyocytes induced distension of caveolae and transgenic mice expressing MURC in the heart exhibited deformation of caveolae in cardiomyocytes.
|
Report
(4 results)
Research Products
(23 results)
-
-
-
[Journal Article] Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.2009
Author(s)
Satomi-Kobayashi S, Ueyama T, Mueller S, Toh R, Masano T, Sakoda T, Rikitake Y, Miyoshi J, Matsubara H, Oh H, Kawashima S, Hirata K, Takai Y.
-
Journal Title
Hypertension 54
Pages: 825-831
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.2008
Author(s)
Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Takahashi T, Harada K, Shioi T, Matsubara H, Oh H.
-
Journal Title
Mol Cell Biol. 28
Pages: 3424-3436
Related Report
Peer Reviewed
-
[Journal Article] MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis.2008
Author(s)
Tagawa M, Ueyama T, Ogata T, Takehara N, Nakajima N, Isodono K, Asada S, Takahashi T, Matsubara H, Oh H.
-
Journal Title
Am J Physiol-Cell Physiol 295
Related Report
Peer Reviewed
-
[Journal Article] Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction.2008
Author(s)
Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H.
-
Journal Title
J Am Coll Cardiol. 52
Pages: 1858-1865
Related Report
Peer Reviewed
-
-
-
[Presentation] MURC induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway.2010
Author(s)
Naito D, Ogata T, Amano K, Taniguchi T, Isodono K, Adachi A, Imoto H, Nakanishi N, Kangawa H, Takahashi T, Ueyama T, Matsubara H
Organizer
International Symposium on Cardiovascular Endocrinology and Metabolism
Place of Presentation
Nara, Japan
Related Report
-
[Presentation] MURC, muscle-restricted coiled- coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes.2010
Author(s)
Taniguchi T, Ogata T, Naito D, Nakanishi N, Miyagawa K, Amano K, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Morimoto T, Takahashi T, Oh H, Ueyama T, Matsubara H
Organizer
American Heart Association (米国心臓病学術会議)
Place of Presentation
Chicago, USA
Related Report
-
-
-
[Presentation] PARM-1, a novel transmembrane molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.2010
Author(s)
Isodono K, Takahashi T, Imoto H, Nakanishi N, Ogata T, Asada S, Adachi A, Kangawa H, Ueyama T, Matsubara H
Organizer
第74回日本循環器学会総会
Place of Presentation
京都
Related Report
-
-
-
-
-
[Presentation] MURC, a muscle-restricted coiled-coil protein, induces cardiomyocyte hypertrophy through the extracellular signal-regulated kinase pathway.2008
Author(s)
Ogata T, Ueyama T, Isodono K, Imoto H, Tagawa M, Takehara N, Asada S, Adachi A, Takahashi T, Matsubara Hiroaki, Oh H.
Organizer
American Heart Association Basic Cardiovascular Sciences Conference
Place of Presentation
Keystone, USA
Related Report
-
[Presentation] A novel muscle-restricted coiled-coil protein, MURC, induces cardiac dysfunction accompanied with an altered gene expression profile.2008
Author(s)
Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Shioi T, Takahashi T, Matsubara Hiroaki, Oh H.
Organizer
第72回日本循環器学会
Place of Presentation
福岡
Related Report
-
[Presentation] A novel but evolutionarily conserved muscle-restricted coiled-coil protein, MURC, regulates myogenic differentiation in C2C12 cells.2008
Author(s)
Tagawa M, Ueyama T, Ogata T, Nakajima N, Isodono K, Asada S, Takehara N, Takahashi T, Matsubara Hiroaki, Oh H.
Organizer
第72回日本循環器学会
Place of Presentation
福岡
Related Report