Role of microRNAs on metabolic control in the heart

• Project/Area Number: 20590864
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto University
• Principal Investigator: ONO Koh Kyoto University, 医学研究科, 講師 (00359275)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: マイクロRNA / 心肥大 / 心不全 / 動脈硬化 / microRNA / コレステロール / SREBP2 / ABCA1 / ATP / ミトコンドリア / 心筋 / 糖代謝

Research Abstract

About 1000miRNAs have already been discovered in human and it is estimated that they can regulate more than 50% of genes. We have shown that specific miRNAs have function in cardiac hypertrophy, heart failure, and metabolic disorders. Some of miRNAs are good targets for the treatment of such disease conditions. We also revealed that circulating miR-1 and miR-133a can be used as biomarkers for myocardial injury and there is a possibility that they can affect in other cells/organs.

Research Products

• [Journal Article] Increased microRNA-1 and microRNA-133a Levels in Serum of Patients with Cardiovascular Disease Indicate the Existence of Myocardial Damage. (2011)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Kinoshita M, Watanabe S, Baba O, Kojima Y, Shizuta S, Imai M, Tamura T, Kita T, Kimura T.
  • Journal Title: Circulation : Cardiovascular Genetics. in press
  • Peer Reviewed
• [Journal Article] MicroRNA links obesity and impaired glucose metabolism. (2011)
  • Author(s): Ono K.
  • Journal Title: Cell Res. in press
  • NAID: 120004225541
  • Peer Reviewed
• [Journal Article] MicroRNAs and Cardiovascular Diseases. (2011)
  • Author(s): Ono K, Kuwabara Y, Han J.
  • Journal Title: FEBS J. 278 Pages: 1619-33
  • NAID: 40020456062
  • Peer Reviewed
• [Journal Article] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2011)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T.
  • Journal Title: Mol Cell Biol. 31 Pages: 744-55
  • NAID: 120002871162
  • Peer Reviewed
• [Journal Article] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo Proc Natl (2010)
  • Author(s): Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • Journal Title: Acad Sci USA. 107 Pages: 17321-6
  • Peer Reviewed
• [Journal Article] Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. (2010)
  • Author(s): Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Molecular Endoclinology. 24 Pages: 1978-87
  • Peer Reviewed
• [Journal Article] Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB (2010)
  • Author(s): Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Pathway Cardiovascular Res. 87 Pages: 656-664
  • Peer Reviewed
• [Journal Article] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes. (2010)
  • Author(s): Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
  • Journal Title: J Biol Chem. 285 Pages: 4920-30
  • Peer Reviewed
• [Journal Article] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • Author(s): Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Journal of Molecular and Cellular Cardiology. 48 Pages: 1157-68
  • NAID: 120002381089
  • Peer Reviewed
• [Journal Article] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo (2010)
  • Author(s): Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107 Pages: 17321-6
  • Peer Reviewed
• [Journal Article] Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. (2010)
  • Author(s): Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Molecular Endoclinology. Volume: 24 Pages: 1978-87
  • Peer Reviewed
• [Journal Article] Acute Doxorubicin Cardiotoxicity Is Associated with miR-146a-induced Inhibition of the Neuregulin-ErbB Pathway (2010)
  • Author(s): Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Cardiovascular Res Volume: 87 Pages: 656-664
  • Peer Reviewed
• [Journal Article] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via ARL2 in neonatal rat cardiac myocytes. (2010)
  • Author(s): Nishi H, Ono K, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe Mori R, Hasegawa K, Kita T, Kimura T.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 4920-30
  • Peer Reviewed
• [Journal Article] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • Author(s): Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T
  • Journal Title: Journal of Molecular and Cellular Cardiology. Volume: 48 Pages: 1157-68
  • NAID: 120002381089
  • Peer Reviewed
• [Journal Article] Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing. (2010)
  • Author(s): Ono K, Wang X, Kim SO, Armstrong LC, Bornstein P, Han J.
  • Journal Title: Protein Cell Pages: 161-173
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure : association with adiponectin. (2010)
  • Author(s): Watanabe S, Tamura T, Ono K, Horiuchi H, Kimura T, Kita T, Furukawa Y.
  • Journal Title: Eur J Heart Failure Volume: 12 Pages: 1214-22
  • Peer Reviewed
• [Journal Article] LOX-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice. (2010)
  • Author(s): Takanabe-Mori R, Ono K, Sowa N, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K.
  • Journal Title: Biochem Biophys Res Commun Volume: 398 Pages: 576-80
  • Peer Reviewed
• [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. (2010)
  • Author(s): Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
  • Journal Title: Cardiovasc Res. Volume: 88 Pages: 314-3
  • Peer Reviewed
• [Journal Article] Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy. (2010)
  • Author(s): Wada H, Shinjo D, Kameda S, Ono K, Satoh N, Morimoto T, Osakada, G, Nakano T, Fujita M, Shimatsu A, Hasegawa K.
  • Journal Title: Heart Vessels. Volume: 25 Pages: 45-50
  • Peer Reviewed
• [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. (2010)
  • Author(s): Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: Atherosclerosis Volume: 208 Pages: 512-517
  • Peer Reviewed
• [Journal Article] A case with sudden onset of position-dependent hypoxemia caused by reopening of foramen ovale. (2010)
  • Author(s): Tada T, Fujita M, Goto T, Tamura T, Ono K, Kita T, Takahashi K, Nagata H, Sakata R, Kimura T
  • Journal Title: Journal of Cardiology Cases Volume: 1
  • Peer Reviewed
• [Journal Article] Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress. (2010)
  • Author(s): Nagao K, Ono K, Iwanaga Y, Tamaki Y, Kojima Y, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Journal of Molecular and Cellular Cardiology.
  • NAID: 120002381089
  • Peer Reviewed
• [Journal Article] Transmitral E/A ratio decreases in association with abdominal fat accumulation in patients with impaired glucose tolerance or mild diabetes without left ventricular hypertrophy. (2010)
  • Author(s): Wada H, Shinjo D, Kameda S, Ono K, Satoh N, Morimoto T, Osakada G, Nakano T, Fujita M, Shimatsu A, Hasegawa K.
  • Journal Title: Heart Vessels. 25 Pages: 45-50
  • Peer Reviewed
• [Journal Article] Soluble VEGF receptor-2 is increased in sera of subjects with metabolic syndrome in association with insulin resistance. (2010)
  • Author(s): Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: Atherosclerosis 208 Pages: 512-517
  • Peer Reviewed
• [Journal Article] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. (2009)
  • Author(s): Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R, Hasegawa K, Kita T, Kimura T.
  • Journal Title: Biochem Biophys Res Commun. 389 Pages: 315-20
  • Peer Reviewed
• [Journal Article] MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells. (2009)
  • Author(s): Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: Circulation J. 73 Pages: 1492-7
  • Peer Reviewed
• [Journal Article] The search for Nkx2-5-regulated genes using purified embryonic stem cell-derived cardiomyocytes with Nkx2-5gene targeting. (2009)
  • Author(s): Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Tanaka M, Kimura T.
  • Journal Title: Biochem Biophys Res Commun. 390 Pages: 821-826
  • Peer Reviewed
• [Journal Article] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. (2009)
  • Author(s): Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Takanabe R, Hasegawa K, Kita T, Kimura T
  • Journal Title: Biochem Biophys Res Commun. 389 Pages: 315-320
  • Peer Reviewed
• [Journal Article] Impact of CYP2C19 Polymorphisms on the Antiplatelet Effect of Clopidogrel in an Actual ClinicalSetting in Japan. (2009)
  • Author(s): Jinnai T, Horiuchi H, Makiyama T, Tazaki J, Tada T, Akao M, Ono K, Hoshino K, Naruse Y, Takahashi K, Watanabe H, Kita T, Kimura T.
  • Journal Title: Circ J. 73 Pages: 498-503
  • Peer Reviewed
• [Journal Article] MicroRNA-1 and MicroRNA-133 in Spontaneous Myocardial Differentiation of Mouse Embryonic Stem Cells. (2009)
  • Author(s): Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T Wada H, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: Circ J. 73 Pages: 1492-1497
  • Peer Reviewed
• [Journal Article] Progranulin Expression in Advanced Human Atherosclerotic Plaque (2009)
  • Author(s): Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K-I, Nishimura M, Yoshida Y, Nakashima Y, Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M.
  • Journal Title: Atherosclerosis. 206 Pages: 102-108
  • Peer Reviewed
• [Journal Article] Progranulin Expression in Advanced Human Atherosclerotic Plaque (2009)
  • Author(s): Sugimoto M, Arai H, Tamura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, Kita T, Harada S, Kamei K, Yokode M.
  • Journal Title: Atherosclerosis. 204 Pages: 388-394
  • Peer Reviewed
• [Journal Article] Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. (2008)
  • Author(s): Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K.
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 728-32
  • Peer Reviewed
• [Journal Article] TG-interacting factor is reauired for the differentiation of preadipocytes. (2008)
  • Author(s): Horie-T, Ono-K, Kinoshita-M, Nishi-H, Nagao-K, Kawamura-T, Abe-Y, Wada-H, Shimatsu-A, Kita-T, Hasegawa-K.
  • Journal Title: J Lipid Res. 49 Pages: 1224-34
  • Peer Reviewed
• [Journal Article] Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes. (2008)
  • Author(s): Horie-T, Ono-K, Nagao-K, Nishi-H, Kinoshita-M, Kawamura-T, Wada-H, Shimatsu-A, Kita-T, Hasegawa-K.
  • Journal Title: J Cell Physiol. 215 Pages: 733-42
  • Peer Reviewed
• [Journal Article] Up-regulated expression of miicroRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. (2008)
  • Author(s): Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K.
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 728-32
  • Peer Reviewed
• [Journal Article] Inhibition of CCN1 suppressed neointimal hyperplasia in a rat balloon injury model. (2008)
  • Author(s): Matsumae-H, Yoshida-Y, Ono-K, Togi-K, Inoue-K, Furukawa-Y, Nakashima-Y, Koima-Y, Nobuyoshi-M, Kita-T, Tanak-M.
  • Journal Title: Arterioscler Thromb Vase Biol. 28 Pages: 1077-83
  • Peer Reviewed
• [Journal Article] Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome. (2008)
  • Author(s): Satoh-N, Wada-H, Ono-K, Yamakage-H, Yamada-K, Nakano-T, Hattori-M, Shimatsu-A, Kuzuya-H, Hasegawa-K.
  • Journal Title: Circulation J 72 Pages: 932-9
  • Peer Reviewed
• [Journal Article] Statins activate GATA-6 and induce differentiated vascular smooth muscle cells. (2008)
  • Author(s): Waa H, Abe M, Ono K, Morimoto T, Kawamura T, Takaya T, Satoh N, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: Circulation J 374 Pages: 731-6
  • Peer Reviewed
• [Journal Article] Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes. (2008)
  • Author(s): Maruyama R, Goto K, Takemra G, Ono K, Nagao K, Horie T, Tsujimoto A, Kanamori H, Miyata S, Ushikoshi H, Nagashima K, Minatoguchi S, Fuj iwara T, Fuj iwara H.
  • Journal Title: Am J Physiol Heart Circ Physiol. 295
  • Peer Reviewed
• [Journal Article] Identification of p300-targeted acetylated residues in GATA-4 during hypertrophic responses in cardiac myocytes. (2008)
  • Author(s): Takaya T, Kawaiura T, Moriffloto T, Ono K, Kita T, Shimatsu A, Hasegawa K.
  • Journal Title: J Biol Chem. 283 Pages: 9828-35
  • Peer Reviewed
• [Journal Article] Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. (2008)
  • Author(s): Sugimoto M, Arai H, Taraura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, Kita T, Harada S, Kamei K, Yokode M.
  • Journal Title: Atherosclerosis. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice. (2008)
  • Author(s): Taiura Y, Sugimoto M, Murayama T, Ueda Y, Kanamori H, Ono K, Ariyasu H, Akamizu T, Kita T, Yokode M, Arai H.
  • Journal Title: Arterioscler Thromb Vase Biol. 28 Pages: 2195-201
  • Peer Reviewed
• [Presentation] Plenary session. (2011)
  • Author(s): Ono K.
  • Organizer: MicroRNA-33 Encoded by an Intron of Srebp2 Cooperates to Control HDL in Vivo.
  • Place of Presentation: 横浜市
• [Presentation] Young Investigator's Award Finalists Lectures-2 (2011)
  • Author(s): Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T.
  • Organizer: MicroRNA-33 Encoded by an Intron of Srebp2 Regulates HDL in vivo.
  • Place of Presentation: 横浜市
• [Presentation] MiR-146a-induced Inhibition of Neuregulinl- (2011)
  • Author(s): Horie T, Ono K, Nishi H, Kinoshita M, Watanabe S, Kuwabara Y, Baba O, Mori R, Nagao K, Iwanaga Y, Nishi E, Hasegawa K, Kita T, Kimura T.
  • Organizer: ErbB4 Pathway may be Involved in Deterioration of Cardiotoxicity under Concurrent Chemotherapy with Doxorubicin and Trastuzumab.
  • Place of Presentation: 横浜市
• [Presentation] Elevated MicroRNA-1 and MicroRNA- (2011)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Baba O, Kita T, Kimura T.
  • Organizer: 133a Levels in Serum of Patients with Acute Cronary Syndrome Indicate the Myocardial Damage.
  • Place of Presentation: 横浜市
• [Presentation] SREBP2のイントロンにコードされるマイクロRNA-33は生体においてHDLの形成を制御する (2010)
  • Author(s): 堀江貴裕、尾野亘、西仁勇、長央和也、木下美菜子、桑原康秀、森利依子、長谷川浩二、北徹、木村剛
  • Organizer: 第2回 京阪神心不全研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-04
• [Presentation] Progranulin is expressed in the human atherosclerotic plaque and reduces IL-8 secretion from smooth muscle cells, endothelial cells, and macrophages. (2010)
  • Author(s): Kojima Y, Ono K, Inoue K, Yoshida Y, Nakashima Y, Nobuyoshi M, Kita T, Kimura T, Tanaka M.
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Ca2+/Calmodulin-dependent kinase kinase beta (CaMKKbeta) contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • Author(s): Watanabe S, Ono K, Horie T, Nagao K, Nishi H, Kinoshita M, Kuwabara Y, Kimura T.
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Midterm outcome of Inoue stent graft for the treatment of thoracic aortic aneurysm and dissections. (2010)
  • Author(s): Tazaki J, Tohma M, Higashitani N, Tamura T, Ono K, Marui A, Sakata R, Inoue K, Kimura T.
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] Impact of microRNAs on cardiomyocyte metabolism. (2010)
  • Author(s): Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] MiR-146-mediated reduction of ErbB4 is an early event in doxorubicin-induced cardiomyocyte cell death. (2010)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Kuwabara Y, Hasegawa K, Kita T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] MicroRNA-27a regulates beta cardiac myosin heavy chaingene expression by targeting thyroid hormone receptor beta-1. (2010)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T.
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Soluble VEGF receptor-2 is a possible novel indicator of impaired angiogenesis in metabolic syndrome. (2010)
  • Author(s): Wada H, Satoh N, Kitaoka S, Ono K, Morimoto T, Kawamura T, Nakano T, Fujita M, Kita T, Shimatsu A, Hasegawa K.
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Long-term clinical outcomes of unprotected left main stenting with sirolimus eluting stents : Correlation between the SYNTAX score and clinical outcomes. (2010)
  • Author(s): Shiomi H, Tamura T, Katoh Y, Tada T, Tazaki J, Jinnai T, Ono K, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] Implantation of sirolimus-eluting stents for coronary artery ostial stenosis in Takayasu artetitis. (2010)
  • Author(s): Shiomi H, Tamura T, Katoh Y, Tada T, Tazaki J, Jinnai T, Ono K, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] MicroRNA-378, which exists intronic lesion of PGC-1beta, deteriorate cardiomyocyte survival under oxidative stress. (2010)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kinoshita M, Kojima Y, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] LOX-1 is required for overexpression fo MCP-1 in mesenteric fat tissue of obese mice. (2010)
  • Author(s): Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Roles of lectin-like oxidized low-density lipoprotein receptor-1 for glucose tolerance in normal and obese mice. (2010)
  • Author(s): Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] MicroRNA 26b family encoded by the introns of small CTD Phosphatases (SCPs) 1 to 3 suppresses phenylephrine-induced cardiomyocyte hypertrophy by targeting TRPC3/6 and GATA4 (2010)
  • Author(s): Ono K, Sowa N, Horie T, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Chicago, Illinois
• [Presentation] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab. (2010)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Chicago, Illinois
• [Presentation] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2010)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Chicago, Illinois
• [Presentation] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome. (2010)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Chicago, Illinois
• [Presentation] MicroRNA-448 regulates adipocyte differentiation by targeting KLF5. (2010)
  • Author(s): Kinoshita M, Ono K, Kuwabara Y, Nishi H, Nagao K, Horie T, Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] Impact of microRNAs on cardiomyocyte metabolism. Topic 12 (2010)
  • Author(s): Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expressions by targeting thyroid hormone receptor beta 1. (2010)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Mori-Takanabe R, Hasegawa K, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] MicroRNA-378, which exists intronic lesion of PGC-lbeta, deteriorates cardiomyocyte survival under oxidative stress. (2010)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kinoshita M, Kojima Y, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] microRNA-146-mediated reduction of ErbB4 is an early event in Doxorubicin-induced cardiomyocyte cell death. (2010)
  • Author(s): Horie T, Ono K, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, takanabe R, Watanabe S, Kojima Y, Nakashima Y, Iwanaga Y, Hasegawa K, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2010)
  • Author(s): Nagao K, Ono K, Horie T, Kinoshita M, Nishi H, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
• [Presentation] MicroRNA 26b family encoded by the introns of small CTD Phosphatases (SCPs) 1 to 3 suppresses phenylephrine-induced cardiomyocyte hypertrophy by targeting TRPC3/6 and GATA4 (2010)
  • Author(s): Ono K, Sowa N, Horie T, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] MiR-146a-induced inhibition of the neuregulin-ErbB4 pathway may be involved in deterioration of cardiotoxicity under concurrent chemotherapy with doxorubicin and Trastuzumab. (2010)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Watanabe S, Kuwabara Y, Nakashima Y, Takanabe-Mori R, Nishi E, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Ca2+/Calumodulin-dependent kinase kinase beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • Author(s): Watanabe S, Ono K, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Baba O, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] MicroRNA-27a regulates beta-myocin heavy chain gene expression by targeting thyroid hormone receptor beta 1 in neonatal rat ventricular myocytes. (2010)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Baba O, Nakashima Y, Nagao K, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] MicroRNA-1 and microRNA-133a are useful as early diagnostic biomarkers in patients with acute coronary syndrome. (2010)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Kinoshita M, Watanabe S, Nakashima Y, Nagao K, Kojima Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Serum adiponectin levels are increased by pathophysiologically induced left ventricular hypertrophy. (2010)
  • Author(s): Wada H, Akao M, Masunaga N, Takaya T, Takanabe-Mori R, Abe M, Funatsu J, Nakajima Y, Kanasaki M, Osakabe G, Nakano T, Ono K, Satoh-Asahara N, Shimatsu A, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Lox-1 is required for the adiposal expression of proinflammatory cytokines in high-fat diet-induced obese mice. (2010)
  • Author(s): Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Metastasis-associated protein S100A4 contributes to cardiac fibrosis through the modulation of PTEN. (2010)
  • Author(s): Tamaki Y, Okuda J, Niizuma S, Kawashima T, Kato T, Inuzuka Y, Shioi T, Ono K, Koshimizu T, Miyazaki S, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA
• [Presentation] Ca2+/calmodulin-dependent kinase kinase beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure. (2010)
  • Author(s): Watanabe S, Ono K, Horie T, Nishi H, Kuwabara Y, Kimura T
  • Organizer: European Society of Cardiology Congress 2010
  • Place of Presentation: Stockholm, Sweden
• [Presentation] ドキソルビシンによる心筋障害にはmiR-146aによるneuregulin/ErbBシグナルの抑制が関わる (2010)
  • Author(s): 堀江貴裕、尾野亘、西仁勇、長央和也、木下美菜子、桑原康秀、森利依子、長谷川浩二、北徹、木村剛
  • Organizer: 第47回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
• [Presentation] MicroRNA-448は脂肪細胞分化を抑制する (2010)
  • Author(s): 木下美菜子、尾野亘、桑原康秀、西仁勇、長央和也、堀江貴裕、森利依子、長谷川浩二、北徹、木村剛
  • Organizer: 第47回日本臨床分子医学会学術集会
  • Place of Presentation: 東京
• [Presentation] MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Ar12 in neonatal rat cardiac myocytes. (2010)
  • Author(s): Ono K, Nishi H, Iwanaga Y, Horie T, Nagao K, Takemura G, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: ISHR World Congress 2010 Kyoto
  • Place of Presentation: Kyoto
• [Presentation] Ca2+/calmodulin-dependent kinase kinase β(CaMKKβ)contributes to energy supply in adaptive phase of pressure-overload-induced heart failure (2010)
  • Author(s): Watanabe S, Ono K, Kimura T
  • Organizer: 第33回心筋代謝研究会
  • Place of Presentation: 東京
• [Presentation] MicroRNA-15b, -16, 195, and -424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] MicroRNA-378, which exists intronic lesion of PGC-1beta, deteriorate cardiomyocyte survival under oxidative stress. (2009)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kojima Y, Kinoshita M, Mori R, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] Aortic stenosis and acquired Type 2a von Willebrand syndrome : correlation between severity of aortic stenosis and gastrointestinal angiodysplasia (Heyde's syndrome) (2009)
  • Author(s): Sowa-N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] Let-7/miR-98 family regulates the expression fo GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • Author(s): Tamura T, Tada T, Ono K, Horiuchi H, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] Roles of lectin-like oxidized low-density lipoprotein (LDL) receptor-1 for maintenance of normal glucose tolerance in normal and obese states. (2009)
  • Author(s): Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Satoh N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] The identification of the NKX2-5-regulated genes using purified ES cell-derived cardiomyocytes (2009)
  • Author(s): Nakashima Y, Ono K, Yoshida Y, Kojima Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-16
• [Presentation] Acute doxorubicin cardiomyopathy is associated with miR-146a-induced inhibition of the neuregulin-ErbB4 pathway. (2009)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-16
• [Presentation] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • Author(s): Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kojima Y, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-16
• [Presentation] Inhibition of histone deacetylation markedly induces myocardial differentiation of induced pluripotent stem cells in mice. (2009)
  • Author(s): Kaichi-S, Hasegawa K, Takaya T, Morimoto T, Kawamura T, Ono K, Yokoo N, Mima T, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-16
• [Presentation] Expression of LOX-1 (OLR1) is markedly increased in the adipose tissue of high-fat diet-induced obese mice in close association with MCP-1. (2009)
  • Author(s): Takanabe-Mori R, Ono K, Abe Y, Wada H, Takaya T, Satoh N, Shimatsu A, Fujito M, Sawamura T, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions 2009
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2009-11-16
• [Presentation] MicroRNA-15b, -16, 195, and -424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • Organizer: 第13回日本心不全学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-01
• [Presentation] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • Author(s): Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kuwabara Y, Tamaki Y, Kojima Y, Iwanaga Y, Kita T
  • Organizer: European Society of Cardiology ongress 2009
  • Place of Presentation: Barcelona, Spein
  • Year and Date: 2009-09-01
• [Presentation] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes (2009)
  • Author(s): Horie T, Ono K, Horie T, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, Kuwabara Y, Abe Y, Takanabe R, Wada H, Hasegawa K, Kita T
  • Organizer: 第32回心筋代謝研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-05
• [Presentation] Let-7/miR-98 family regulates the expression of GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • Author(s): Sowa-N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-05-23
• [Presentation] Acute doxorubicin cardiomyopathy is associated with miR-146a-induced inhibition of the neuregulin-ErbB4 pathway. (2009)
  • Author(s): Horie T, Ono K, lwanaga Y, Nishi H, Nagao K, Kinoshita M, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress. (2009)
  • Author(s): Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Kojima Y, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] MicroRNA-15b, -16, 195, and-424, which have the same seed sequence, regulate ADP-rybosylation factor-like 2 and cellular ATP levels in neonatal rat cardiomyocytes (2009)
  • Author(s): Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara-Y, Takanabe-Mori R, Hasegawa K, Takemura G, Iwanaga Y, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] MicroRNA-378, which exists intronic lesion of PGC-lbeta, deteriorate cardiomyocyte survival under oxidative stress. (2009)
  • Author(s): Kuwabara Y, Ono K, Horie T, Nishi H, Nagao K, Watanabe S, Kojima Y, Kinoshita M, Mori R, Kita T, Kimura T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] Let-7/miR-98 family regulates the expression of GLUT4 by targeting Mef-2C in metabolic control of cardiomyocytes. (2009)
  • Author(s): Sowa N, Ono K, Horie T, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Takanabe-Mori R, Kita T, Kimura T, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: Orlando, Florida
• [Presentation] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the development of cardiomyocyte survival. (2009)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Kuwabara Y, Hasegawa K, Kita T
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
• [Presentation] Neural cell adhesion molecule is upregulated by metabolic stress and enhances the cardiomyocyte survival. (2009)
  • Author(s): Nagao K, Ono K, Horie T, Kinoshita M, Nishi H, Tamaki Y, Kuwabara Y, Iwanaga Y, Kita T.
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
• [Presentation] microRNAをターゲットとした肥満に伴う心血管系疾患治療法の開発 (2008)
  • Author(s): 尾野亘, 堀江貴裕, 西仁勇, 長央和也, 木下美菜子, 北徹
  • Organizer: 第4回メタボリックシンドローム研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-19
• [Presentation] Neural cell adhesion molecule isupregulated by metabolic stress and enhances the cardiomyocyte survival rate through neurite-cardiomyocyte communication. (2008)
  • Author(s): Nagao K, Ono K, Horie T, Kojima Y, Nishi H, Kinoshita M, Kita T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the deterioration of cardiomyocyte survival. (2008)
  • Author(s): Horie T, Ono K, Iwanaga Y, Nishi H, Nagao K, Kinoshita M, Mori R, Hasegawa K, Kita T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Upregulation of microRNA-27a, which downregulates retionoid X receptor a, controls cardiac myosin heavy chain gene expression in neonatal rat cardioyocyte. (2008)
  • Author(s): Nishi H, Ono K, Kinoshita M, Nagao K, Horie T, Takanabe R, Hasegawa K, Iwanaga Y, Kita T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Up-regulated expression of microRNA-143 in association with obesity in the adipose tissue of mice fed with high fat diet. (2008)
  • Author(s): Takanabe R, Ono K, Takaya T, Horie T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Neural cell adhesion molecule is upregulated by metabolic stress and enhances the cardiomyocyte survival rate through neurite-cardiomyocyte communication (2008)
  • Author(s): Nagao K, Ono K, Horie T, Koj ima Y, Nishi H, Kinoshita M, Kita T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] NF-kB-dependent induction of microRNA-146 downregulates ErbB4 and may be involved in the deterioration of cardiomyocyte survival (2008)
  • Author(s): Horie T, Ono K, Iwanaga Y, NishiH, Nagao K, Kinoshita M, Mori R, Hasegawa K, Kita T
  • Organizer: American Heart Association Ammual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Upregulation of microRNA-27a, which downregulates retionoid X receptor a, controls cardiac myosin heavy chain gene expression in neonatal rat cardioyocyte (2008)
  • Author(s): Nishi H, Ono K, Kinoshita M, Nagao K, Horie T, Takanabe R, Hasegawa K, Iwanaga Y, Kita T
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Up-regulatex expression of microaRNA-143 in association with obesity in the adipose tissue of mice fed with high fat diet (2008)
  • Author(s): Takanabe R, Ono K, Takaya T, Horie T, Wada H, Kita T, Shimatsu A, Hasegawa K
  • Organizer: American Heart Association Annual Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] IGF axis and adiponectin as prognostic markers of patients with congestive heart failure (2008)
  • Author(s): Watanabe S, Tamura T, Ono K, Kita T, Kimura T, Furukawa Y
  • Organizer: European Society of Cardiology Congres
  • Place of Presentation: Munich, Germany
• [Presentation] Upregulation of microRNA targeting retionoid X receptor a contributes to development of cardiachypertrophy (2008)
  • Author(s): Nishi H, Ono K, Horie T. Kinoshita M. Nagao K, Iwanaga Y, Hasegawa K, Kita T
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control incardiac myocytes (2008)
  • Author(s): Horie T, Ono K, Kinoshita M, Nishi H, Nagao K, Mori R, Iwanaga Y, Hasegawa K, Kita T
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Overexpression of microRNA-1 in mouse embryonic stem cells represses myocardial differentiation (2008)
  • Author(s): Takaya-T, Kawamura T, Ono K, Takanabe R, Kaichi S, Kita T, Wada H, Morimoto T, Shimatsu A, Hasegawa K
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] A soluble VEGF receptor-2 is possible novel biomarker of cardiovascular risk in the metabolic syndrome. (2008)
  • Author(s): Wada H, Satoh N, Ono K, Shinjo D, Morimoto T, Nakano T, Shimatsu A, Fujita M, Hasegawa K
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Cyclin-dependent kinase-9 is required for the differentiation of mouse ES cells into cardiac myocytes. (2008)
  • Author(s): Kaichi S, Takaya T, Sunagawa Y, Kawamura T, Ono K, Moriraoto T, Kita T, Baba S, Hidaka K, Morisaki T, Heike T, Nakahata T, Shimatsu A, Hasegawa K
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] miR-133は心筋細胞における代謝調節においてKLF15をターゲットとしてGLUT4の発現を制御している. (2008)
  • Author(s): 堀江貴裕, 尾野亘, 西仁勇, 長央和也, 木下美菜子, 森利依子, 岩永善高, 長谷川浩二, 北徹
  • Organizer: 第45回日本臨床分子医学会学術集会
  • Place of Presentation: 神戸
• [Presentation] miR-27aはラット心筋細胞においてミオシン重鎖の発現を制御する (2008)
  • Author(s): 西仁勇, 尾野亘, 木下美菜子, 長央和也, 堀江貴裕, 岩永善高, 森利依子, 長谷川浩二, 北徹
  • Organizer: 第45回本臨床分子医学会学術集会
  • Place of Presentation: 神戸
• [Presentation] microRNA-1の過剰発現はマウスES細胞の心筋分化を抑制する (2008)
  • Author(s): 高谷智英, 川村晃久, 尾野亘, 高鍋利依子, 鶏内伸二, 馬場志郎, 平家俊男, 中畑龍俊, 森本達也, 北徹, 島津章, 長谷川浩二
  • Organizer: 第45回日本臨床分子医学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Trapping genes that encode secreted and transmembrane proteins in H9C2 cardiomyoblasts. (2008)
  • Author(s): Nagao K, Ono K, Horie T, Nishi H, Kinoshita M, Hasegawa K, Kita T
  • Organizer: 第31回心筋代謝研究会
  • Place of Presentation: 東京
• [Book] Micro RNA-33を介したHDL-コレステロール調節のあらたなメカニズム.医学のあゆみ(237) (2011)
  • Author(s): 尾野亘、木村剛
• [Book] miRNA-33は生体内でHDLコレステロールを制御する 実験医学(29(4)) (2011)
  • Author(s): 尾野亘、堀江貴裕、木村剛、北徹
• [Book] SREBP2のイントロンにコードされるマイクロRNA-33は生体においてHDL形成を制御するTherapeutic Research(32(6)) (2011)
  • Author(s): 尾野亘
• [Book] 「心筋梗塞モデル(小動物)」循環器疾患-疾患モデルの作成と利用 (2010)
  • Author(s): 尾野亘
  • Publisher: Life Science Information center.
• [Book] Biology topics. MicroRNAと心疾患. Bio Clinica.(25(6)) (2010)
  • Author(s): 尾野亘、木村剛
• [Book] Biology topics.MicroRNAと心疾患 (2010)
  • Author(s): 尾野亘、木村剛
  • Total Pages: 4
  • Publisher: Bio Clinica
• [Book] 「心筋梗塞モデル(小動物)」循環器疾患-疾患モデルの作成と利用 (2010)
  • Author(s): 尾野亘
  • Total Pages: 5
  • Publisher: Life Science Information center
• [Book] 分子心血管病「メタボリックシンドロームと冠動脈イベントのリスク」 (2009)
  • Author(s): 尾野亘、木村剛
  • Total Pages: 9
  • Publisher: 先端医学社
• [Remarks] ホームページ等
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [Remarks]
  • URL: http://kyoto-u-cardio.jp/kisokenkyu/metabolic/
• [Remarks]
  • URL: http://kyoto-u-cardio.ip/kisokenkyu/metabolic/