Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure
| Project/Area Number |
20590869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TANNO Masaya Sapporo Medical University, 医学部, 助教 (00398322)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Tetsuji 札幌医科大学, 医学部, 教授 (90199951)
HORIO Yoshiyuki 札幌医科大学, 医学部, 教授 (30181530)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子心臓病態学 / 心不全 / エピジェネティクス / ヒストン脱アセチル化酵素 / 細胞内局在 / 酸化ストレス / 細胞死 |
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| Research Abstract |
SIRT1 shuttled between the nuclei and cytoplasm. Nuclear SIRT1 suppressed oxidative stress-induced cell death by up-regulating Mn-SOD. SIRT1 accumulated in nuclei in cardiomyocytes of failing hearts probably as an endogenous adaptive mechanism and activation of SIRT1 by resveratrol reduced the mortality in cardiomyopathic hamsters. These findings suggest that SIRT1 activator may be a novel therapeutic approach for chronic heart failure.
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Report
(4 results)
Research Products
(17 results)
