Role of connexin-43 in protective signaling incardiomyocyte
| Project/Area Number |
20590870
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
MIURA Tetsuji Sapporo Medical University, 医学部, 教授 (90199951)
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Takayuki 札幌医科大学, 医学部, 講師 (00336405)
TANNO Masaya 札幌医科大学, 医学部, 講師 (00398322)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | コネキシン / 細胞シグナル / 心筋細胞 / 細胞死 / connexin-43 / signal transduction / G protein coupled receptor / β-subunit / mitochondria / 細胞内情報電達 / 細胞内情報伝達 |
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| Research Abstract |
This study aimed to clarify role of connexin-43 (Cx43) in a major cytoprotective signaling, PI3K-Akt-GSK-3β signaling in cardiomyocytes. We found that Cx43 in the sarcolemma contributes to activation of class I_B P13K as a co-factor of β subunit of G proteins. This role of Cx43 is specific to regulation of class I_B P13K and is not required for activation of class I_A PI3K. Cx43 in mitochondria, being necessary for redox signaling by activated mitochondrial ATP-sensitive K^+ channel, was found to be dispensable in PI3K-Akt-GSK-3β signaling by G-protein coupled receptors.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.2010
Author(s)
Hotta H, Miura T. Miki T, Togashi N, Maeda T. Kim SJ, Tanno M Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K.
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Journal Title
Circ Res 106
Pages: 129-132
Related Report
Peer Reviewed
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[Journal Article] Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.2008
Author(s)
Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, Marber MS.
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Journal Title
Circ Res 103
Pages: 307-314
Related Report
Peer Reviewed
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