| Project/Area Number |
20590872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Keio University |
|---|
Principal Investigator |
ANZAI Toshihisa Keio University, 医学部, 講師 (60232089)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Toshiyuki 慶應義塾大学, 医学部, 共同研究員 (20286470)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOYASU Shigeo 慶應義塾大学, 医学部, 教授 (90153684)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 心筋梗塞 / 炎症 / 左室リモデリング / 樹状細胞 / 免疫応答 / 循環器・高血圧 / 免疫学 / 細胞・組織 / 病理学 / ストレス |
|---|
| Research Abstract |
An excessive inflammatory response after myocardial infarction (MI) is reported to be associated with cardiac dysfunction and poor clinical outcomes after MI. However, the precise regulatory mechanism to control the inflammatory response has been unclear. The present study demonstrated that bone-marrow derived dendritic cells (BMDCs) have a protective effect against cardiac dysfunction after MI through decreased macrophages and inflammatory monocytes-mediated inflammatory response, extracellular matrix degradation, and cardiac apoptosis.
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