The role of signal repressor SOCS3 in development of heart failure

• Project/Area Number: 20590873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kurume University
• Principal Investigator: YASUKAWA Hideo Kurume University, 医学部, 講師 (60289361)
• Co-Investigator(Kenkyū-buntansha): FUTAMATA Nobuyoshi 久留米大学, 医学部, 助教 (70412509)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心不全 / サイトカイン / JAK / STAT / SOCS / 心筋梗塞 / JAK/STAT / SOCS3 / Jak

Research Abstract

We generated cardiac-specific SOCS3 knockout (SOCS3-CKO) mice. These mice showed increased activation of gp130 downstream signaling from 15 weeks of age and developed heart failure from around 25 weeks of age. Ca^<2+> transients were significantly increased in SOCS3-CKO failing hearts. We also found various ventricular arrhythmias in SOCS3-CKO non-failing hearts. To determine whether the cardiac phenotype is mediated through gp130 signaling, we generated cardiac-specific gp130 and SOCS3 double knockout mice. Double KO mice lived significantly longer and showed completely different histological abnormalities compared to SOCS3-CKO mice. These results demonstrate the critical role of SOCS3 regulation on cardiac gp130 signaling in the pathogenesis of contractile dysfunction and ventricular arrhythmias.

Research Products

• [Journal Article] Reduction and activation of circulating dendritic cells in patients with decompensated heart failure. (2011)
  • Author(s): Sugi Y, Yasukawa H, Kai H, Fukui D, Futamata N, Mawatari K, Oba T, Nagata N, Kyougoku S, Koga M, Imaizumi T.
  • Journal Title: Int J Cardiol. 147 Pages: 258-64
  • Peer Reviewed
• [Journal Article] II.疾患の病因と病態 7.たこつぼ心筋症の病因をめぐって. (2011)
  • Author(s): 安川秀雄、南知子、今泉勉
  • Journal Title: Annual Review循環器2011 Pages: 100-104
• [Journal Article] Suppressors of Cytokine Signaling (SOCS) Proteins and JAK/STAT Pathways : Regulation of T-Cell Inflammation by SOCS1 and SOCS3 (2011)
  • Author(s): Tamiya T, Kashiwagi I, Takahashi R, Yasukawa H, Yoshimura A
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31 Pages: 980-985
  • Peer Reviewed
• [Journal Article] Factors associated with plasma ghrelin level in Japanese general population. (2011)
  • Author(s): Nanjo Y, Adachi H, Hirai Y, Enomoto M, Fukami A, Otsuka M, Yoshikawa K, Yokoi K, Ogata K, Tsukagawa E, Kasahara A, Murayama K, Yasukawa H, Kojima M, Imaizumi T
  • Journal Title: Clin Endocrinol Volume: 74 Pages: 453-458
  • Peer Reviewed
• [Journal Article] Reduction and activation of circulating dendritic cells in patients with decompen sated heart failure. (2011)
  • Author(s): Sugi Y, Yasukawa H, Kai H, Fukui D, Futamata N, Mawatari K, Oba T, Nagata T, Kyougoku S, Koga M, Imaizumi T
  • Journal Title: Int J Cardiology Volume: 147 Pages: 707-712
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats. (2011)
  • Author(s): Takemiya K, Kai H, Yasukawa H, Tahara N, Kato S, Imaizumi T
  • Journal Title: Basic Res Cardiol Volume: 105 Pages: 409-417
  • Peer Reviewed
• [Journal Article] サイトカインネットワークと動脈硬化の病態.医学のあゆみ (2010)
  • Author(s): 安川秀雄、今泉勉
  • Journal Title: サイトカインと疾患 Vol.234 No.5 Pages: 527-531
• [Journal Article] 動脈硬化の病態におけるサイトカインとT細胞の役割. (2010)
  • Author(s): 安川秀雄、Ziad Mallat、大場豊治、今泉勉
  • Journal Title: 実験医学<増刊:サイトカインによる免疫制御と疾患> Vol.28 No.12
• [Journal Article] 最新・心不全 Update-研究と臨床の最前線、虚血性心不全 -梗塞後心筋リモデリングの分子機序 (2009)
  • Author(s): 安川秀雄、今泉勉
  • Journal Title: 医学のあゆみ 232 Pages: 316-321
• [Journal Article] 大動脈瘤の分子生物学、炎症シグナルと組織障害 (2009)
  • Author(s): 安川秀雄、大島英樹、今泉勉
  • Journal Title: 血管医学 10 Pages: 43-48
• [Journal Article] Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. (2009)
  • Author(s): Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z
  • Journal Title: J Exp Med 206 Pages: 2067-2077
  • Peer Reviewed
• [Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis. (2009)
  • Author(s): Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis (2009)
  • Author(s): Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A
  • Journal Title: PLoS One 4
  • Peer Reviewed
• [Journal Article] Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis (2009)
  • Author(s): Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z
  • Journal Title: J Exp Med 206 Pages: 2067-2077
  • Peer Reviewed
• [Journal Article] 最新・心不全 Update 研究と臨床の最前線、虚血性心不全 -梗塞後心筋リモデリングの分子機序 (2009)
  • Author(s): 安川秀雄、今泉勉
  • Journal Title: 医学のあゆみ 232 Pages: 316-321
• [Journal Article] 心筋症の最前線 循環器専門医のための診る・識る・治す心筋症診断update臨床症状、身体所見 (2008)
  • Author(s): 安川秀雄、永田隆信、京極幸子、今泉勉
  • Journal Title: Heart View Pages: 8-12
• [Journal Article] 新しい診断と治療のABC 心筋症 肥大型心筋症の予後 (2008)
  • Author(s): 安川秀雄、大場豊治、馬渡一寿、今泉勉
  • Journal Title: 最新医学別冊 Pages: 89-99
• [Journal Article] うっ血性心不全 テーラーメード治療を目指した治療薬の選択と使用法ガイドラインUpdate (2008)
  • Author(s): 二又誠儀、安川秀雄、今泉勉
  • Journal Title: Medical Practice 25 Pages: 1551-1560
• [Journal Article] 心不全研究の最前線"細胞内シグナリングと治療標的分子"、心不全の病態におけるJAKシグナル制御の役割、-Negative Regulation of JAK Signaling and Cardiac Injury- (2008)
  • Author(s): 安川秀雄、大場豊治、馬渡一寿、今泉勉
  • Journal Title: 心臓 40 Pages: 176-180
• [Journal Article] Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. (2008)
  • Author(s): Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A.
  • Journal Title: J Immunol 180 Pages: 3746-56
  • Peer Reviewed
• [Journal Article] Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. (2008)
  • Author(s): Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A.
  • Journal Title: Hepatology 47 Pages: 1644-54
  • Peer Reviewed
• [Journal Article] SOCS1 protects mice against concanavalin-A-induced hepatitis by inhibiting Fas, STAT1 and JNK-mediated apoptosis. (2008)
  • Author(s): Torisu, et al.
  • Journal Title: Hepatology 47 Pages: 1644-1654
  • Peer Reviewed
• [Journal Article] Loss of SOCS1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFNγ on STAT3 and Smads. (2008)
  • Author(s): Tanaka, et al.
  • Journal Title: J Immunol 180 Pages: 3746-3755
  • Peer Reviewed
• [Journal Article] 心不全研究の最前線“細胞内シグナリングと治療標的分子"、心不全の病態におけるJAKシグナル制御の役割、-Negative Regulation of JAK Signaling and Cardiac In jury-. (2008)
  • Author(s): 安川秀雄, 他
  • Journal Title: 心臓 40 Pages: 176-180
• [Journal Article] うつ血性心不全テーラーメード治療を目指した治療薬の選択と使用法ガイドラインUpdate (2008)
  • Author(s): 二又誠儀, 他
  • Journal Title: Medical Practice 25 Pages: 1551-1560
• [Journal Article] Neuronal suppressor of cytokine signaling-3 (Socs3) deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase (PI3K) signaling.
  • Author(s): Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. (in press)
  • Peer Reviewed
• [Journal Article] Neuronal suppressor of cytokine signaling-3 (Socs3) deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase (PI3K) signaling
  • Author(s): Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Reduction and activation of circulating dendritic cells in patients with decompensated heart failure.Int J Cardiol
  • Author(s): Sugi Y, Yasukawa H, Kai H, Fukui D, Futamata N, Mawatari K, Oba T, Nagata T, Kyougoku S, Koga M, Imaizumi T
  • Journal Title: Int J Cardiology (印刷中)
  • Peer Reviewed
• [Presentation] Activation of protective intracellular signaling pathways in the heart by skeletal muscle-derived cytokines during remote ischemic preconditioning (2010)
  • Author(s): Oba T, Yasukawa H, Futamata N, Mawatari K, Nagata T, Kyougoku S, Oshima H, Imaizumi T
  • Organizer: The American Heart Association, The 83th Scientific Sessions
  • Place of Presentation: シカゴ
  • Year and Date: 2010-11-17
• [Presentation] Reduction of myocardial ischemia-reperfusion injury in cardiac-specific SOCS3 deficient mice by activating cardioprotective signaling pathways (2010)
  • Author(s): Nagata T, Yasukawa H, Oba T, Mawatari K, Kyougoku S, Ohshima H, Yajima T, Knowlton K, Imaizumi T
  • Organizer: The American Heart Association, The 83th Scientific Sessions
  • Place of Presentation: シカゴ
  • Year and Date: 2010-11-17
• [Presentation] The role of dendritic cells in the pathogenesis of heart failure (2010)
  • Author(s): Yasukawa H, Sugi Y, Ohshima H, Imaizumi T
  • Organizer: The XX World Congress of the ISHR (International Society for Heart Research)
  • Place of Presentation: 京都
  • Year and Date: 2010-05-16
• [Presentation] The Role of Suppressor of Cytokine Signaling-3 in Lipopolysa ccharide-induced Left Ventricular Dysfunction in Mice (2010)
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Kirk U Knowlton, Imaizumi T
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-22
• [Presentation] Lacking SOCS3 in Cardiomyocyte Improved Left Ventricular Remodeling and Survival After Acute Myocardial Infarction (2010)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Nagata T, Kyougoku S, Imaizumi T
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-21
• [Presentation] Pioglitazone attenuates atherosclerotic plaque inflammation in impaired glucose tolerance-Evaluation by serial 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (2010)
  • Author(s): Mizoguchi M, Tahara N, Nitta Y, Kodama N, Oba T, Mawatari K, Yasukawa H, Ishibashi M, Imaizumi T
  • Organizer: The American Heart Association, The 83th Scientific Sessions
  • Place of Presentation: Chicago, USA
• [Presentation] Activation of protective intracellular signaling pathways in the heart by skeletal muscle-derived cytokines during remote ischemic preconditioning. (2010)
  • Author(s): Oba T, Yasukawa H, Futamata N, Mawatari K, Nagata T, Kyougoku S, Oshima H, Imaizumi T
  • Organizer: The American Heart Association, The 83th Scientific Sessions
  • Place of Presentation: Chicago, USA
• [Presentation] Reduction of myocardial ischemia-reperfusion injury in cardiac-specific SOCS3 deficient mice by activating cardioprotective signaling pathways. (2010)
  • Author(s): Nagata T, Yasukawa H, Oba T, Mawatari K, Kyougoku S, Ohshima H, Yajima T, Knowlton K, Imaizumi T
  • Organizer: The American Heart Association, The 83th Scientific Sessions
  • Place of Presentation: Chicago, USA
• [Presentation] The role of dendritic cells in the pathogenesis of heart failure. (2010)
  • Author(s): Yasukawa H, Sugi Y, Ohshima H, Imaizumi T
  • Organizer: The XX World Congress of the ISHR (International Society for Heart Research), Symposium: The Molecular mechanism of myocarditis and heart failure
  • Place of Presentation: Kyoto
• [Presentation] Cardiac-specific deletion of SOCS3 improved lipopolysaccharid e-induced cardiac dysfunction via mitochondria stabilization (2009)
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Nagata T, Kyogoku S, Hoshijima M, Kirk U Knowlton, Imaizumi T
  • Organizer: The American Heart Association Scientific Sessions 2009
  • Place of Presentation: 米国オーランド
  • Year and Date: 2009-11-15
• [Presentation] Cardiac-Specific Deletion of SOCS3 Prevented Myocardial Apoptosis After Acute Myocardial Infarction Through Inhibiting Mitochondrial Damage (2009)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Yajima T, Hoshijima M, Knowlton KU, Imaizumi T
  • Organizer: The American Heart Association Scientific Sessions 2009
  • Place of Presentation: 米国オーランド
  • Year and Date: 2009-11-15
• [Presentation] Cardiac-Specific Deletion of SOCS3 prevented Myocardial Apoptosis After Myocardial Infarction through inhibiting Mitochondrial damage (2009)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Yajima T, Hoshijima M, Knowlton KU, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-01
• [Presentation] Negative regulation of cytokine signaling and endotoxemia-ind uced myocardial dysfunction (2009)
  • Author(s): 安川秀雄, 今泉勉
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-01
• [Presentation] Prevention of Doxorubicin Induced Left Ventricular Dysfunction in Cardiac-Specific SOCS3 Deficient Mice (2009)
  • Author(s): Kyougoku S, Yasukawa H, Oba T, Futamata N, Mawatari K, Nagata T, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-31
• [Presentation] Suppressor of ERK1/2 Signaling Sprouty4 Does Not Play a Role in the Development of Cardiac Remodeling After Acute Myocardial Infarctio (2009)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Futamata N, Nagata T, Sachiko K, Sasaki K, Yoshimura A, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-31
• [Presentation] サイトカインの機能調節と心筋梗塞後心室リモデリング (2009)
  • Author(s): 安川秀雄、大場豊治、永田隆信、今泉勉
  • Organizer: 第29回日本小児循環動態研究会
  • Place of Presentation: 久留米
  • Year and Date: 2009-10-10
• [Presentation] Cardiacspecific deletion of SOCS3 improved lipopolysaccharide - induced cardiac dysfunction via mitochondria stabilization. (2009)
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Nagata T, Kyogoku S, Hoshijima M, Knowlton KU, Imaizumi T
  • Organizer: The American Heart Association, The 82th Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Cardiac-specific deletion of SOCS3 myocardial apoptosis after acute myocardial infarction through inhibiting mitochondrial damage. (2009)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Yajima T, Hoshijima M, Knowlton KU, Imaizumi T prevented
  • Organizer: The American Heart Association, The 82th Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Prevention of Doxorubicin Induced Left Ventricular Dysfunction in Cardiac-Specific SOCS3 Deficient Mice. (2009)
  • Author(s): Kyougoku S, Yasukawa H, Oba T, Futamata N, Mawatari K, Nagata T, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Suppressor of ERK1/2 Signaling Sprouty4 Does Not Play a Role in the Development of Cardiac Remodeling After Acute Myocardial Infarction. (2009)
  • Author(s): Mawatari K, Yasukawa H, Oba T, Futamata N, Nagata T, Sachiko K, Sasaki K, Yoshimura A, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Cardiac-Specific Deletion of SOCS3 prevented Myocardial Apoptosis After Myocardial Infarction through inhibiting Mitochondrial damage. (2009)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Yajima T, Hoshijima M, Knowlton KU, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Negative regulation of cytokine signaling and endotoxemia-induced myocardial dysfunction. (2009)
  • Author(s): Yasukawa H, Imaizumi T
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Negative regulation of cytokine signaling and endotoxemia-induced myocardial dysfunction. (2009)
  • Author(s): Yasukawa H
  • Organizer: The 13th Japanese Heart Failure Society Meeting
  • Place of Presentation: Fukuoka
• [Presentation] The Role of Suppressor of Cytokine Signaling-3 in LPS - induced Left Ventricular Dysfunction in Mice. (2009)
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Kirk U Knowlton, Imaizumi T
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Lacking SOCS3 in Cardiomyocyte Improved Left Ventricular Remodeling and Survival After Acute Myocardial Infarction. (2009)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Nagata T, Kyougoku S, Imaizumi T
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Cardiac-specific deletion of SOCS3 improved cardiac function and survival after acute myocardial infarction in mice. (2008)
  • Author(s): Oba T
  • Organizer: The American Heart Association Scientific Sessions 2008
  • Place of Presentation: 米国 : ニューオーリンズ
  • Year and Date: 2008-11-11
• [Presentation] Cardiac-specific SOCS3 deficient mice shows resistance to lipopolysacc haride-induced left ventricular dysfunction. (2008)
  • Author(s): Futamata N
  • Organizer: The American Heart Association Scientific Sessions 2008
  • Place of Presentation: 米国 : ニューオーリンズ
  • Year and Date: 2008-11-09
• [Presentation] Suppressor of cytokine signaling-3 (SOCS3) and cardiac injury during ischemia (2008)
  • Author(s): Yasukawa H
  • Organizer: 2008 La Jolla-Rome-Yamaguchi-Seoul Conference on Cardiovascular Research
  • Place of Presentation: 韓国 : ソウル
  • Year and Date: 2008-10-26
• [Presentation] Cardiac-specific SOCS3 deficient mice shows resistance to lipopolysaccharide-induced left ventricular dysfunction. (2008)
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Nagata T, Fukui D, Hoshijima M, Imaizumi T
  • Organizer: The American Heart Association, The 81^<th> Scientific Sessions
  • Place of Presentation: New Orleans, USA
• [Presentation] Factors for inflammation of carotid plaque may be different from those for carotid plaque formation. (2008)
  • Author(s): Mizoguchi M, Tahara N, Yasukawa H, Yamagishi S, Ishibashi M, Imaizumi T
  • Organizer: The American Heart Association, The 81^<th> Scientific Sessions
  • Place of Presentation: New Orleans, USA
• [Presentation] Cardiac-specific deletion of SOCS3 improved cardiac function and survival after acute myocardial infarction in mice. (2008)
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Fukui D, Sugi Y, Hoshijima M, Yajima T, Knowlton KU, Imaizumi T
  • Organizer: The American Heart Association, The 81^<th> Scientific Sessions
  • Place of Presentation: New Orleans, USA
• [Presentation] Suppressor of cytokine signaling-3 (SOCS3) and cardiac injury during ischemia. (2008)
  • Author(s): Yasukawa H, Imaizumi T
  • Organizer: 2008 La Jolla-Rome-Yamaguchi-Seoul Conference on Cardiovascular Research -Frontiers in Cardiovascular Cellular and Molecular Therapeutics-
  • Place of Presentation: Seoul, Korea
• [Presentation] Negative regulation of JAK signaling and heart failure. (2008)
  • Author(s): YasukawaH, Imaizumi T
  • Organizer: 第11日本心不全学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cardiac-specific deletion of suppressor of cytokine signaling -3 prevents LPS-Induced cardiac dysfunction viamitochondrial stabilization.
  • Author(s): Futamata N, Yasukawa H, Oba T, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Yajima T, Hoshijima M, Knowlton KU, Imaizumi T
  • Organizer: 第74回日本循環器学会学術集会
• [Presentation] Cardiac-specific deletion of SOCS3 prevented myocardial apoptosis after acute myocardial infarction via inhibiting mitochondrial damage.
  • Author(s): Oba T, Yasukawa H, Sasaki K, Futamata N, Mawatari K, Nagata T, Kyogoku S, Ohshima H, Fukui D, Sugi Y, Imaizumi T
  • Organizer: 第74回日本循環器学会学術集会
• [Presentation] Inhibition of doxorubicin induced cardiomyopathy in cardiacspecific SOCS3 deficient mice.
  • Author(s): Kyogoku S, Yasukawa H, Oba T, Futamata N, Mawatari K, Nagata T, Ohshima H, Imaizumi T
  • Organizer: 第74回日本循環器学会学術集会
• [Book] 第1部心機能評価を知るための基礎医学§1分子から細胞まで 6.筋原線維の構造と収縮弛緩特性.診療に活かす心機能評価-症例で身につける評価法のポイント (2011)
  • Author(s): 大場豊治、安川秀雄、今泉勉
  • Total Pages: 290
  • Publisher: 羊土社
• [Book] 実地医家に必須の56疾患(和田攻、大久保昭行、矢崎義雄、大内尉義編)(I.循環器疾患 7.うっ血性心不全.テーラーメイド治療のための治療薬の選択と使用法ガイドライン Medical Practice vol.27 臨時増刊号) (2010)
  • Author(s): 二又誠義、安川秀雄、大内田昌直、今泉勉
  • Publisher: 文光堂、東京
• [Book] 診療に活かす心機能評価-症例で身につける評価法のポイント(北風政史編)(第1部心機能評価を知るための基礎医学 §1 分子から細胞まで 6.筋原線維の構造と収縮弛緩特性) (2010)
  • Author(s): 大場豊治、安川秀雄、今泉勉
  • Publisher: 羊土社、東京
• [Book] I.循環器疾患 7.うっ血性心不全 テーラーメイド治療のための治療薬の選択と使用法ガイドライン 実地医家に必須の56疾患(Medical Practice vol.27臨時増刊号) (2010)
  • Author(s): 二又誠儀、安川秀雄、大内田昌直、今泉勉
  • Total Pages: 393
  • Publisher: 羊土社
• [Book] 新・診療プラクティス12 冠動脈疾患の病態に迫る(吉川純一、伊藤浩編)(虚血性不全心の病態に迫る心筋障害に迫る左室リモデリングと心不全) (2008)
  • Author(s): 安川秀雄、今泉勉
  • Publisher: 文光堂、東京
• [Book] 新・診療プラクティス12 冠動脈疾患の病態に迫る (2008)
  • Author(s): 安川秀雄, 今泉勉
  • Total Pages: 351
  • Publisher: 文光堂
• [Remarks] ホームページ等
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  • URL: http://www.med.kurume-u.ac.jp/med/imed3/
• [Patent(Industrial Property Rights)] SOCS3遺伝子がコードするSOCS3タンパク質の発現を抑制し得るRNA干渉分子、及びその利用 (2009)
  • Inventor(s): 安川秀雄、大場豊治、今泉勉
  • Industrial Property Rights Holder: 久留米大学
  • Filing Date: 2009