| Project/Area Number |
20590876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHNEDA Osamu University of Tsukuba, 大学院・人間総合科学研究科, 教授 (30311872)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Toshiharu 筑波大学, 大学院・人間総合科学研究科, 助教 (50400677)
長野 真澄 筑波大学, 大学院・人間総合科学研究科, 助教 (30436282)
|
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANO Masumi 筑波大学, 大学院・人間総合科学研究科, 助教 (30436282)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再生医学 / 循環器・高血圧 / 移植・再生医療 / 細胞・組織 / 創傷治癒 / 虚血 |
|---|
| Research Abstract |
We have reported previously that ALDH-Low EPC possess hypoxic response. In this study, we examined how hypoxia-inducible factor (HIF) is involved in the repair of ischemic tissue in a mouse flap model. HIF-2alpha but not HIF-1alpha was highly associated with the reduced tissue damage in ischemia. Finally, we found that HIF-target genes, VEGF and CXCR4, have an important role for the neovascularization in ischemic tissue.
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