Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.
| Project/Area Number |
20590883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
HIRANO Mayumi Kyushu University, 大学院・医学研究院, 助教 (80336031)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Katsuya 九州大学, 医学研究院, 准教授 (80291516)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子血管病態学 / 内皮細胞の透過性 / プロテイナーゼ活性化型受容体 / ミオシン軽鎖リン酸化 / Rhaキナーゼ / G蛋白質 / 細胞質Ca^<2+>濃度 / 内皮細胞 / Rhoキナーゼ / ミオシン軽鎖リン酸 / アクチンストレスファイバー |
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| Research Abstract |
The present study elucidated the role of proteinase-activated receptors(PARs) in the early phase of the development of atherosclerotic vascular lesions. Thrombin increased endothelial permeability by two distinct pathways by activating PAR1 ; one is mediated by Gα13, and independent of Ca^<2+>, but dependent of Rho kinase-mediated MLC di-phosphorylation ; other is mediated by Gαq, and independent of MLC di-phosphorylation, but dependent on Ca^<2+>.
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Report
(4 results)
Research Products
(29 results)
