| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The present study elucidated the role of proteinase-activated receptors(PARs) in the early phase of the development of atherosclerotic vascular lesions. Thrombin increased endothelial permeability by two distinct pathways by activating PAR1 ; one is mediated by Gα13, and independent of Ca^<2+>, but dependent of Rho kinase-mediated MLC di-phosphorylation ; other is mediated by Gαq, and independent of MLC di-phosphorylation, but dependent on Ca^<2+>.
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