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Analysis of ARIA that is a novel gene regulating endothelial apoptosis in the regulation of neovessel formation

Research Project

Project/Area Number 20590885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

IKEDA Koji  Kyoto Prefectural University of Medicine, 医学研究科, 助教 (90423871)

Co-Investigator(Renkei-kenkyūsha) MATSUBARA Hiroaki  京都府立医科大学, 医学研究科, 教授 (10239072)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords分子血管病態学 / 血管新生 / 血管内皮細胞 / アポトーシス / PI3K / Akt
Research Abstract

We have generated ARIA (former BLADE) knockout mice, and analyzed the ARIA function in the regulation of neovessel formation. By using the hind-limb ischemia model, we revealed that genetic deletion of ARIA substantiallyenhanced the ischemia-induced neovascularization. Moreover, we found that ARIA is highly expressed in endothelial progenitor cells as well, and regulates their angiogenic functions by modulating the PI3K/Akt pathway.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Apoptosis regulator through modulating IAP expression (ARIA) regulates the PI3K/Akt pathway in endothelial and endothelial progenitor cells.2011

    • Author(s)
      Koide M, Ikeda K (corresponding author), Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Proc Natl Acad Sci USA in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] Endothelial FGF receptor signaling accelerates atherosclerosis.2011

    • Author(s)
      Che J, Okigaki M, Takahashi T, Katsume A, Adachi Y, Yamaguchi S, Matsunaga S, Takeda M, Matsui A, Kishita E, Ikeda K, Yamada H, Matsubara H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 300(1)

    • Related Report
      2010 Final Research Report
  • [Journal Article] p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic condition.2010

    • Author(s)
      Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, Ikeda K, Tatsumi T, Matsubara H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 299(6)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.2010

    • Author(s)
      Nakagawa Y, Ikeda K (corresponding author), Akakabe Y, Koide M, Uraoka M, Yutaka KT, Kurimoto-Nakano R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30(10)

      Pages: 1908-1915

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pathophysiology of vascular calcification : pivotal role of cellular senescence in vascular smooth muscle cells.2010

    • Author(s)
      Burton DG, Matsubara H, Ikeda K (last author).
    • Journal Title

      Exp Gerontol. 45(11)

      Pages: 819-824

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bone marrow AT1 augments neointimal formation by promoting mobilization of smooth muscle progenitors via platelet-derived SDF-1alpha.2010

    • Author(s)
      Yokoi H, Yamada H, Tsubakimoto Y, Takata H, Kawahito H, Kishida S, Kato T, Matsui A, Hirai H, Ashihara E, Maekawa T, Iwai M, Horiuchi M, Ikeda K, Takahashi T, Okigaki M, Matsubara H.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30(1)

      Pages: 60-67

    • Related Report
      2010 Final Research Report
  • [Journal Article] Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.2010

    • Author(s)
      Nakagawa Y, Ikeda K, Akakabe Y, Koide M, Uraoka M, Yutaka KT, Kurimoto-Nakano R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 30 Pages: 1908-1915

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology of vascular calcification : pivotal role of cellular senescence in vascular smooth muscle cells.2010

    • Author(s)
      Burton DG, Matsubara H, Ikeda K.
    • Journal Title

      Exp Gerontol.

      Volume: 45 Pages: 819-824

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-22009

    • Author(s)
      Ikeda K, Nakano R, Uraoka M, Nakagawa Y, Koide M, Katsume A, Minamino K, Yamada E, Yamada H, Quertermous T, Matsubara H
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 82278232-82278232

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replicative senescent vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transistion2009

    • Author(s)
      Nakano-Kurimoto R, Ikeda K, Uraoka M, Nakagawa Y, Yutaka K, Koide M, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H
    • Journal Title

      Am J Physiol Heart Circ Physiol 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system2009

    • Author(s)
      Uraoka M, Ikeda K, Nakagawa Y, Koide M, Akakabe Y, Nakano-Kurimoto R, Takahashi T, Matoba S, Yamada H, Okigaki M, Matsubara H
    • Journal Title

      Biochem Biophys Res Commun. 390

      Pages: 12021207-12021207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ARIA regulates ischemia-induced angiogenesis and vasculogenesis through modulating the PI3K/Akt/eNOS signaling pathway.2010

    • Author(s)
      Koide M, Ikeda K, Kitamura Y, Akakabe Y, Nakagawa Y, Matsubara H.
    • Organizer
      AHA scientific sessions, Circulation 122(23) : A-14736
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of ARIA as a novel factor regulating endothelial cell apoptosis and angiogenesis in vivo.2010

    • Author(s)
      Koide M, Ikeda K, Nakagawa Y, Akakabe Y, Kurimoto R, Matsubara H.
    • Organizer
      第74回日本循環器学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of ARIA as a novel factor regulating endothelial apoptosis and angiogenesis in vivo.2010

    • Author(s)
      Koide M, Ikeda K, Akakabe Y, Uraoka M, Nakagawa Y, Kurimoto R, Matsubara H.
    • Organizer
      心血管内分泌学会
    • Place of Presentation
      奈良
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of ARIA as a novel factor regulating endothelial cell apoptosis and angiogenesis in vivo.2009

    • Author(s)
      Masahiro Koide, Koji Ikeda, Maki Uraoka, Yusuke Nakagawa, Yoshiki Akakabe, Ritsuko Kurimoto, Hiroaki Matsubara.
    • Organizer
      American Heart Association(米国心臓病学術会議)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular identification and characterization of a novel gene thatregulates endothetial cell apoptosis and angiogenesis2008

    • Author(s)
      Koji Ikeda
    • Organizer
      アメリカ心臓病学会
    • Place of Presentation
      米国ニューオーリンズ
    • Related Report
      2008 Annual Research Report
  • [Book] 血管新生療法(循環器疾患-疾患モデルの作成と利用)第2章9節2010

    • Author(s)
      池田宏二, 他
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2010 Final Research Report
  • [Book] 循環器疾患-疾患モデルの作成と利用第2章 第9節 血管新生療法2010

    • Author(s)
      池田宏二
    • Publisher
      株式会社 エル・アイ・シー
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.f.kpu-m.ac.jp/k/med2/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/med2/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.f.kup-m.ac.jp/k/med2/

    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 肥満・インスリン感受性を制御する遺伝子およびそのノックアウト動物および本意電子の機能調節を介した肥満及び/又はメタボリック症候群の予防及び/又は治療薬のスクリーニング2011

    • Inventor(s)
      池田宏二、松原弘明、赤壁佳樹
    • Industrial Property Rights Holder
      池田宏二、松原弘明、赤壁佳樹
    • Industrial Property Number
      2011-009375
    • Filing Date
      2011-01-20
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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