Anti-atherosclerotic effects of an erythropoietin receptor agonist
Project/Area Number |
20590887
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Jichi Medical University |
Principal Investigator |
UEBA Hiroto Jichi Medical University, 医学部, 講師 (80316546)
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Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Masanobu 自治医科大学, 医学部, 教授 (40161286)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | エリスロポエチン / アゴニスト / 動脈硬化 / 血管内皮細胞 / アポトーシス / シグナル伝達 / WHHLMIウサギ |
Research Abstract |
Erythropoietin (EPO) has been shown to have nonhematopoietic, tissue-protective effects, including suppression of atherosclerosis. However, prothrombotic effects of EPO hinder its clinical use in non-anemic patients. In the present study, we examined anti-atherosclerotic effects of an EPO receptor agonist (EPORA) that does not have adverse effects of EPO using myocardial infarction?prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. EPORA demonstrated anti-apoptotic and anti-inflammatory effects and significantly suppressed the progression of coronary atherosclerotic lesions in WHHLMI rabbits. Because EPORA has pleiotropic effects just like statins, it may be a promising candidate for a novel anti-atherosclerotic agent.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Role of osteopontin and αvβ3 integrin in the regulation of endothelial cell survival by endothelial cell-monocyte interaction.2010
Author(s)
Ueba, H, Hashimoto, S, Umemoto, T, Ako, J, Momomura, S, Kawakami, M.
Organizer
第42回日本動脈硬化学会総会
Place of Presentation
岐阜市
Year and Date
2010-07-15
Related Report
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[Presentation] Cardiomyocyte protection by a nonerythropoietic, tissue-protective peptide derived from erythropoietin.2010
Author(s)
Ueba, H, Brines, M, Yamin, M, Umemoto, T, Ako, J, Momomura, S, Cerami, A, Kawakami, M.
Organizer
第74回日本循環器学会総会
Place of Presentation
京都市
Year and Date
2010-03-05
Related Report
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[Presentation] Induction of endothelial cell apoptosis and monocyte matrix metalloproteinase-9 production by C-reactive protein.2009
Author(s)
Ueba, H, Nabata, A, Kuroki, M, Hashimoto, S, Umemoto, T, Sugawara, Y, Kubo, N, Momomura, S, Kawakami, M.
Organizer
第73回日本循環器学会総会
Place of Presentation
大阪市
Year and Date
2009-03-21
Related Report
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