| Project/Area Number |
20590887
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
UEBA Hiroto Jichi Medical University, 医学部, 講師 (80316546)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Masanobu 自治医科大学, 医学部, 教授 (40161286)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | エリスロポエチン / アゴニスト / 動脈硬化 / 血管内皮細胞 / アポトーシス / シグナル伝達 / WHHLMIウサギ |
|---|
| Research Abstract |
Erythropoietin (EPO) has been shown to have nonhematopoietic, tissue-protective effects, including suppression of atherosclerosis. However, prothrombotic effects of EPO hinder its clinical use in non-anemic patients. In the present study, we examined anti-atherosclerotic effects of an EPO receptor agonist (EPORA) that does not have adverse effects of EPO using myocardial infarction?prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits. EPORA demonstrated anti-apoptotic and anti-inflammatory effects and significantly suppressed the progression of coronary atherosclerotic lesions in WHHLMI rabbits. Because EPORA has pleiotropic effects just like statins, it may be a promising candidate for a novel anti-atherosclerotic agent.
|
