• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effect of aging and smoking on the phagocytosis of apoptotic cells in alveolar macrophages

Research Project

Project/Area Number 20590890
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

NASUHARA Yasuyuki  Hokkaido University, 病院, 准教授 (30322811)

Co-Investigator(Kenkyū-buntansha) ITO Yoko  北海道大学, 病院, 助教 (90286451)
BETSUYAKU Tomoko  北海道大学, 大学院・医学研究科, 准教授 (60333605)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords閉塞性肺疾患 / マクロファージ / 喫煙 / アポトーシス / 炎症 / マクロフィージ
Research Abstract

Our aims of this study are to examine expressions of various receptors for recognition and/or clearance of apoptotic cells on macrophages and assess the relationship with aging and/or smoking. The expression of phosphatidylserine receptor (PSR) and scavenger receptor A (SR-A) in alveolar macrophages was downregulated in smokers when compared to lifelong non-smokers only in the older subjects, but not in younger subjects. The expression of PSR is elevated on U937-derived macrophage like cells if these are incubated in CSE. The cigarette smoke extract-induced upregulation of PSR was inhibited by the vascular endothelial growth factor (VEGF) receptor blockade, SU5614, in U937-derived macrophage-like cells. These results showed that VEGF was indirectly associated with the ability to phagocytose apoptotic cells through the expression of PSR.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (103 results)

All 2011 2010 2009 2008

All Journal Article (42 results) (of which Peer Reviewed: 42 results) Presentation (61 results)

  • [Journal Article] The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema.2011

    • Author(s)
      Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.
    • Journal Title

      Am J Respir Crit Care Med. 183

      Pages: 876-884

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of catalase in pulmonary fibrosis.2011

    • Author(s)
      Odajima N, Betsuyaku T, Nagai K, Moriyama C, Wang DH, Takigawa T, Ogino K, Nishimura M.
    • Journal Title

      Respiratory Research. 11

      Pages: 183-183

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema.2011

    • Author(s)
      Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.
    • Journal Title

      Am J Respir Crit Care Med.

      Volume: 183 Pages: 876-884

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis.2010

    • Author(s)
      Odajima N, Betsuyaku T, Yoshida T, Hosokawa T, Nishimura M.
    • Journal Title

      Hum Pathol. 41

      Pages: 935-943

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts.2010

    • Author(s)
      Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA.
    • Journal Title

      Am J Respir Cell Mol Biol. 43

      Pages: 576-584

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics.2010

    • Author(s)
      Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M.
    • Journal Title

      Respir Med. 104

      Pages: 1809-1816

    • NAID

      120002678124

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Levels of transferrin in bronchoalv eolar lavage fluid in sarcoidosis.2010

    • Author(s)
      Shigemura M, Nasuhara Y, Konno S, Hattori T, Shimizu C, Matsuno K, Nishimura M.
    • Journal Title

      Lung. 188

      Pages: 151-157

    • NAID

      120002834677

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines.2010

    • Author(s)
      Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M.
    • Journal Title

      Am J Respir Cell Mol Biol. 42

      Pages: 304-311

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin attenuates elastaseand cigarette smoke-induced pulmonary emphysema in mice.2010

    • Author(s)
      Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol. 296

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of catalase in pulmonary fibrosis.2010

    • Author(s)
      Odajima N, Betsuyaku T, Nagai K, Moriyama C, Wang DH, Takigawa T, Ogino K, Nishimura M.
    • Journal Title

      Respiratory Research

      Volume: 11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喘息として加療されフローボリューム曲線が発見の契機となった成人重複大動脈弓の1例2010

    • Author(s)
      吉田貴之, 今野哲, 高橋歩, 南須原康行, 別役智子, 西村正治
    • Journal Title

      日本呼吸器学会雑誌

      Volume: 48 Pages: 229-234

    • NAID

      10026930665

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis.2010

    • Author(s)
      Odajima N, Betsuyaku T, Yoshida T, Hosokawa T, Nishimura M.
    • Journal Title

      Hum Pathol.

      Volume: 41 Pages: 935-943

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts.2010

    • Author(s)
      Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA.
    • Journal Title

      Am J Respir Cell Mol Biol.

      Volume: 43 Pages: 576-584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of follicular bronchiolitis associated with asthma, eosinophilia, and increased immunoglobulin E.2010

    • Author(s)
      Shimizu K, Konno S, Nasuhara Y, Tanino M, Matsuno Y, Nishimura M.
    • Journal Title

      J Asthma

      Volume: 47 Pages: 1161-1164

    • NAID

      120003537884

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Airflow limitation and airway dimensions assessed perbronchial generation in older asthmatics.2010

    • Author(s)
      Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M.
    • Journal Title

      Respir Med.

      Volume: 104 Pages: 1809-1816

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endobronchial actinomycosis associated with a foreign body--successful short-term treatment with antibiotics--.2010

    • Author(s)
      Maki K, Shinagawa N, Nasuhara Y, Oizumi S, Domen H, Haga H, Nishimura M.
    • Journal Title

      Intern Med.

      Volume: 49 Pages: 1293-1296

    • NAID

      130000299527

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhaled Granulocyte/Macrophage-Colony Stimulating Factor as Therapy of Pulmonary Alveolar Proteinosis2010

    • Author(s)
      Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K
    • Journal Title

      Am J Respir Crit Care Med (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Levels of transferrin in bronchoalveolar lavage fluid in sarcoidosis2010

    • Author(s)
      Shigemura M, Nasuhara Y, Konno S, Hattori T, Shimizu C, Matsuno K, Nishimura M
    • Journal Title

      Lung 188

      Pages: 151-157

    • NAID

      120002834677

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines2010

    • Author(s)
      Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
    • Journal Title

      Am J Respir Cell Mol Biol 42

      Pages: 304-311

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages.2009

    • Author(s)
      Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M.
    • Journal Title

      Biogerontology. 10

      Pages: 173-180

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinases in blood from patients with LAM.2009

    • Author(s)
      Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M.
    • Journal Title

      Respir Med. 103

      Pages: 124-129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between improvedairflow limitation and changes in airway caliber induced by inhaled anticholinergic agents in COPD.2009

    • Author(s)
      Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T,Nishimura M.
    • Journal Title

      Thorax 64

      Pages: 332-338

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胸痛を呈し、胸膜病変の診断と病勢評価にFDG-PET(fluorodeoxyglucose-positron emission tomography)が有用であったサルコイドーシスの1例2009

    • Author(s)
      服部健史, 今野哲, 猪又崇志, 南須原康行, 別役智子, 西村正治
    • Journal Title

      日本呼吸器学会雑誌 47

      Pages: 658-662

    • NAID

      10027676759

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the pharmacodynamics of biapenem in bronchial epithelial lining fluid in healthy volunteers given half-hour and three-hour intravenous infusions2009

    • Author(s)
      Kikuchi E, Kikuchi J, Nasuhara Y, Oizumi S, Ishizaka A, Nishimura M
    • Journal Title

      Antimicrob Agents Chemother 53

      Pages: 2799-2803

    • NAID

      120001415113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice2009

    • Author(s)
      Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages2009

    • Author(s)
      Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
    • Journal Title

      Biogerontology 10

      Pages: 173-180

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinases in blood from patients with LAM2009

    • Author(s)
      Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M
    • Journal Title

      Respir Med 103

      Pages: 124-129

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergic agents in COPD2009

    • Author(s)
      Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
    • Journal Title

      Thorax 64

      Pages: 332-338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice2009

    • Author(s)
      Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
    • Journal Title

      Am J Phvsiol Lung Cell Mol Phvsiol 296(4)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between improved airflow limitation and changes in airway calibre induced by inhaled anticholinergic agents in COPD2009

    • Author(s)
      Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
    • Journal Title

      Thorax 64(4)

      Pages: 332-338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages2009

    • Author(s)
      Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
    • Journal Title

      Biogerontology 10(2)

      Pages: 173-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distal airways in mice exposed to cigarette smoke : Nrf2-regulated genes are increased in Clara cells2008

    • Author(s)
      Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.
    • Journal Title

      Am J Respir Cell Mol Biol 39

      Pages: 400-411

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure2008

    • Author(s)
      Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M.
    • Journal Title

      Respir Res 9

      Pages: 7-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] the Hokkaido COPD Cohort Study Group.:"Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients"2008

    • Author(s)
      Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M
    • Journal Title

      Eur Respir J. 32(2)

      Pages: 372-378

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of basement membrane in EMM PRIN/CD147 induction in rat tracheal epithelial cells2008

    • Author(s)
      Hosokawa T, Betsuyaku T, Odajima N, Suzuki M, Mochitate K, Nasuhara Y, Nishimura M.
    • Journal Title

      Biochem Biophys Res Commun 368(2)

      Pages: 426-432

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual oxidase 1 and 2 expression in airwayepithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease2008

    • Author(s)
      Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
    • Journal Title

      Antioxid Redox Signal 10(4)

      Pages: 705-714

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of protein carbonylation in allergic airway inflammation2008

    • Author(s)
      Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M.
    • Journal Title

      Free Radic Res 42(11-12)

      Pages: 921-929

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients2008

    • Author(s)
      Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M.
    • Journal Title

      Inhal Toxicol 20(3)

      Pages: 349-3

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-Regulated NF-E2-Related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease2008

    • Author(s)
      Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
    • Journal Title

      Am J Respir Cell Mol Biol 39(6)

      Pages: 673-682

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of protein carbonylation in allergic airway inflammation2008

    • Author(s)
      Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
    • Journal Title

      Free Radic Res 42(11-12)

      Pages: 921-929

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease2008

    • Author(s)
      Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
    • Journal Title

      Am J Respir Cell Mol Biol 39(6)

      Pages: 673-682

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients2008

    • Author(s)
      Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M ; Hokkaido COPD Cohort Study Groun
    • Journal Title

      Eur Respir J 32(2)

      Pages: 372-378

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 国立大学付属病院医療安全管理協議会 医師GRMアンケート結果2010

    • Author(s)
      南須原康行
    • Organizer
      第5回医療の質・安全学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glycan X, a keratan sulfate oligosaccharide, attenuates elastase-induced lung inflammation and emphysema in mice.2010

    • Author(s)
      Yoshida T, Gao C, Betsuyaku T, Ota F, Matsumoto A, Nishimura M, Taniguchi N
    • Organizer
      The 106^<th> American Thoracic Society International Conference.
    • Place of Presentation
      New Orleans USA.
    • Year and Date
      2010-06-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Glycan X, a keratan sulfate oligosaccharide, attenuates elastase-induced lung inflammation and emphysema in mice2010

    • Author(s)
      Yoshida T, Gao C, Betsuyaku T, Ota F, Matsumoto A, Nishimura M, Taniguchi N
    • Organizer
      The 106^<th> American Thoracic Society International Conference
    • Place of Presentation
      New Orleans USA
    • Year and Date
      2010-05-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aging affects the airway expression of Nrf2 in response to cigarette smoke.2010

    • Author(s)
      Nagai K, Betsuyaku T, Nishimura M
    • Organizer
      The 106th American Thoracic Society International Conference.
    • Place of Presentation
      New Orleans, USA.
    • Year and Date
      2010-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Aging affects the airway expression of Nrf2 in response to cigarette smoke2010

    • Author(s)
      Nagai K, Betsuyaku T, Nishimura M
    • Organizer
      The 106^<th> American Thoracic Society International Conference
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparison of airway. remodelling assessed by three-dimensional CT between Bronchial Asthma and chronic obstructive pulmonary disease2010

    • Author(s)
      Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M
    • Organizer
      The 106^<th> American Thoracic Society International Conference
    • Place of Presentation
      New Orleans USA
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床安定期の中・高年気管支喘息患者における肺CT3次元気道解析でみた気道病変と気流閉塞との関係2010

    • Author(s)
      清水薫子, 長谷川大, 牧田比呂仁, 南須原康行, 今野哲, 西村正治
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 加齢、短期間喫煙曝露、その後の禁煙が細気管支上皮におけるmicro RNA (miRNA)プロファイルに及ぼす影響2010

    • Author(s)
      守山千夏, 別役智子, 西村正治
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] MMP活性阻害能を有するグリコサミノグリカン(Glycan X)のエラスターゼ誘導マウス肺気腫モデルにおける抗炎症および気腫形成抑制効果の検討2010

    • Author(s)
      吉田貴之, 高叢笑, 別役智子, 太田芙美, 松本明郎, 西村正治, 谷口直之
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アレルギー性気道炎症モデルにおけるDHMEQの効果2010

    • Author(s)
      清水健一, 今野哲, 清水薫子, 谷口菜津子, 伊佐田朗, 高橋歩, 服部健史, 梅澤一夫, 尾崎倫孝, 藤堂省, 西村正治
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加齢、短期間喫煙曝露、その後の禁煙が細気管支上皮におけるmicro RNA(miRNA)プロファイルに及ぼす影響2010

    • Author(s)
      守山千夏, 別役智子, 西村正治
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] COPD患者の1秒量の再現性に与える因子に関する検討2010

    • Author(s)
      山本雅史, 今野哲, 南須原康行, 牧田比呂仁, 西村正治
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 呼吸器疾患のリスクマネジメント2010

    • Author(s)
      南須原康行
    • Organizer
      第50回日本呼吸器学会学術講演会教育講演10
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 呼吸器疾患のリスクマネジメント2010

    • Author(s)
      南須原康行
    • Organizer
      第50回日本呼吸器学会学術講演会 教育講演10
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of catalase in cigarette smoke(CS) -induced pulmonary inflammation and emphysema in murine model.2010

    • Author(s)
      Inomata T, Betsuyaku T, Odajima N, Nagai K, Yoshida T, Moriyama C, Maki K, Nishimura M
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Association of β2-adrenoreseptor genotype with bronchodilator responses (BDR) in COPD.2010

    • Author(s)
      Konno S, Makita H, Hasegawa M, Shimizu K, Taniguchi N, Nasuhara Y, Betsuyaku T, Nishimura M
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 呼吸器内科医を目指す女性医師のキャリアパスならびにキャリア支援2010

    • Author(s)
      駒瀬裕子, 別役智子
    • Organizer
      第50回日本呼吸器学会学術講演会 シンポジウム6 呼吸器科医をいかに育成するか
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 若い喫煙者にこそ、積極的な禁煙治療を2010

    • Author(s)
      別役智子
    • Organizer
      第50回日本呼吸器学会学術講演会 ランチョンセミナー6
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of catalase in cigarette smoke (CS)-induced pulmonary inflammation and emphysema in murine model2010

    • Author(s)
      Inomata T, Betsuyaku T, Odajima N, Nagai K, Yoshida T, Moriyama C, Maki K, Nishimura M
    • Organizer
      第50回日本呼吸器学会学術講演会English mini symposium
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of β2-adrenoreseptor genotype with bronchodilator responses (BDR) in COPD2010

    • Author(s)
      Konno S, Makita H, Hasegawa M, Shimizu K, Taniguchi N, Nasuhara Y, Betsuyaku T, Nishimura M
    • Organizer
      第50回日本呼吸器学会学術講演会English mini symposium
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患(COPD)の自然歴に関する研究-北海道COPDコホート研究4年後の追跡調査-2010

    • Author(s)
      牧田比呂仁, 長井桂, 南須原康行, 長谷川大, 守山千夏, 別役智子, 西村正治
    • Organizer
      第107回日本内科学会総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease.2009

    • Author(s)
      Hasegawa M, Nasuhara Y, akita H, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease2009

    • Author(s)
      Hasegawa M, Nasuhara Y, Makita H, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid (BALF) in lipopolysaccaride (LPS) induced lung injury.2009

    • Author(s)
      Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients.2009

    • Author(s)
      Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] アレルギー性気道炎症モデルにおける気道被覆液中のグルタチオン化蛋白の検討2009

    • Author(s)
      長井桂, 別役智子, 南須原康行, 近藤宇史, 西村正治
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid(BALF)in lipopolysaccaride(LPS)induced lung injury2009

    • Author(s)
      Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients2009

    • Author(s)
      Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      第49回日本呼吸器学会
    • Place of Presentation
      東京:東京国際フォーラム
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients.2009

    • Author(s)
      Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference.
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States.
    • Year and Date
      2009-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Protein S-glutathionylation in the Epithelial Lining Fluid during Allergic Airway Inflammation.2009

    • Author(s)
      Nagai K, Betsuyaku T, Nasuhara Y, Kondo T, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference.
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States.
    • Year and Date
      2009-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Duration of cigarette smoke (CS) exposure affects the resolution of lung inflammation after cessation in mice.2009

    • Author(s)
      Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States.
    • Year and Date
      2009-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid (BALF) in lipopolysaccaride (LPS) induced lung injury.2009

    • Author(s)
      Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States.
    • Year and Date
      2009-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients2009

    • Author(s)
      Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Protein S-glutathionylation in the Epithelial Lining Fluid during Allergic Airway Inflammation2009

    • Author(s)
      Nagai K, Betsuyaku T, Nasuhara Y, Kondo T, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Duration of cigarette smoke(CS)exposure affects the resolution of lung inflammation after cessation in mice2009

    • Author(s)
      Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kinetics of various oxidative stress markers in BAL fluid in lipopolysaccaride(LPS)-induced lung injury2009

    • Author(s)
      Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
    • Organizer
      The 105^<th> American Thoracic Society International Conference
    • Place of Presentation
      The San Diego Convention Center, San Diego, CA, United States
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hokkaido COPD Cohort Study Group : Annual decline in forced expiratory volume in 1 sec (FEV1) in patients with COPD before and after introduction of tiotropium2008

    • Author(s)
      Fuke S, Makita H, Hasegawa M, Nasuhara Y, Betsuyaku T, Nishimura M
    • Organizer
      European Respiratory Society AnnualCongress 2008
    • Place of Presentation
      Berlin Germany
    • Year and Date
      2008-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] The Hokkaido COPD Cohort Study Group : Body mass index is an independent risk factor for exacerbation in patients with COPD2008

    • Author(s)
      Nasuhara Y, Makita H, Nagai K, Betsuyaku T, Nishimura M
    • Organizer
      European Respiratory Society Annual Congress 2008
    • Place of Presentation
      Berlin Germany
    • Year and Date
      2008-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Bronchodilation response assessed by computed tomography in chronic obstructive pulmonary disease (COPD)2008

    • Author(s)
      Hasegawa M, Nasuhara Y, Makita H, Odajima N, Ito Y, Nagai K, Betsuyaku T, Nishimura M
    • Organizer
      European Respiratory Society Annual Congress 2008
    • Place of Presentation
      Berlin Germany
    • Year and Date
      2008-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] EMS10-2 Laminills α5 and γ2 and VEGF are Down-regulated in Lung in Cigarette Smoke-exposed Mice and Emphysema Subjects2008

    • Author(s)
      Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk TL, Nguyet M. Nguyen, Senior RM, Nishimura M
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] アレルギー性気道炎症モデル及び喘息患者における気道被覆液中のカルボニル化蛋白の検討2008

    • Author(s)
      長井桂, 別役智子, 今野哲, 伊藤洋子, 南須原康行, 檜澤伸之, 西村正治
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] PP772線維化肺におけるcatalase発現の検討2008

    • Author(s)
      小田島奈央, 別役智子, 南須原康行, 西村正治
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] COPDの気流制限に及ぼす3次元CT画像で評価した気腫病変と気道病変の関与2008

    • Author(s)
      長谷川大, 南須原康行, 牧田比呂仁, 別役智子, 西村正治
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] MS255・PP695単回喫煙暴露マウスモデルでの好中球性炎症および細気管支上皮のケモカイン産生におよぼす加齢の影響2008

    • Author(s)
      守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臨床安定期の中・高年気管支喘息患者における気流制限と肺CT3次元気道解析でみた気道病変との関係2008

    • Author(s)
      清水薫子, 南須原康行, 長谷川大, 牧田比呂仁, 今野哲, 別役智子, 西村正治
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸 : 神戸コンベンションセンター
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke (CS) Exposure in Aged Mice2008

    • Author(s)
      Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of airway disease and emphysema to airflow limitation in chronic obstructive pulmonary disease (COPD) assessed by three-dimensional computed tomography2008

    • Author(s)
      Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Aging affects lipopolysaccaride (LPS)-induced upregulation of heme oxygenase-1 (HO-1) in the lungs and alveolar macrophages (AMs)2008

    • Author(s)
      Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Aged mice exhibit enhanced expression of chemokines in bronchiolar epithelium and rapid neutrophil accumulation in response to single cigarette smoke (CS) exposure2008

    • Author(s)
      Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
    • Organizer
      The 104th American Thoracic Society InternationalConference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Eosinophils mediate albumin carbonylation in the epithelial lining fluid during allergic airway inflammation2008

    • Author(s)
      Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Decreased catalase expression in bronchiolization and squamous metaplasia in lung fibrosis2008

    • Author(s)
      Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma2008

    • Author(s)
      Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Laminins alpha5 and gamma2 and VEGF are down-regulated in lung in cigarette smoke (CS)-exposed mice and emphysema subjects2008

    • Author(s)
      Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T, Nguyen MN, Senior RM, Nishimura M
    • Organizer
      The 104th American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke(CS)Exposure in Aged Mice2008

    • Author(s)
      Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aging Affects Lipopolysaccaride (LPS)-Induced Upregulation.of Heme Oxygenase-1 (HO-1) in the Lungs and Alveolar Macrophages (AMs)2008

    • Author(s)
      Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation2008

    • Author(s)
      Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO. TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) Assessed by Three-dimensional Computed Tomography2008

    • Author(s)
      Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis2008

    • Author(s)
      Odajima N, Betsuyaku T, Nasuhara Y. Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke (CS)-Exposed Mice and Emphysema Subjects2008

    • Author(s)
      Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T,Nguyen NM, Senior RM, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke (CS) Exposure2008

    • Author(s)
      Moriyama C, Betsuyaku T, Ito Y, Hamamura I, J. Hata J, Takahashi H. Nasuhara Y. Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma2008

    • Author(s)
      Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
    • Organizer
      The 104^<th> American Thoracic Society International Conference
    • Place of Presentation
      Toronto Canada : METRO TORONTO CONVENTION CENTRE
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi