| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Using animal models, we evaluated the role of OPN in eosinophilic airway inflammation, allergen sensitization, airway remodeling and emphysema. We have demonstrated that OPN is a novel chamoattractant of eosinophils and is involved in the eosinophilic airway inflammation in asthma. Whereas, OPN inhibited systemic allergen sensitization. The effect of OPN on airway remodeling and emphysema was not observed.
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