| Project/Area Number |
20590892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
SHIBATA Yoko Yamagata University, 医学部, 講師 (60333978)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Tetsu 山形大学, 医学部, 講師 (40359568)
ABE Shuichi 山形大学, 医学部, 助教 (40400543)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | MafB / 喫煙 / 肺気腫 / 転写因子 / 遺伝子改変マウス |
|---|
| Research Abstract |
We generated the macrophage scavenger receptor enhancer-promoter dominant negative (DN) MafB TG mice that could repress MafB transcription activity only in macrophages. In this TG mouse, alveolar macrophages decreased, possibly due to enhanced apoptosis. Furthermore, the alteration of cell shapes and the reduction of phagocytic capacity were observed in this TG mouse. This study revealed that the various in vivo role of transcription factor MafB, such as suppression of apoptosis, maintenance of cell shape, and regulation of phagocytic function.
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