| Project/Area Number |
20590896
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
ITO Isao Kyoto University, 医学研究科, 助教 (40447975)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MISHIMA Michiaki 京都大学, 医学研究科呼吸器内科, 教授 (60190625)
NIIMI Akio 京都大学, 医学研究科呼吸器内科, 准教授 (30252513)
MURO Shigeo 京都大学, 医学研究科呼吸器内科, 助教 (60344454)
HOSHINO Yuma 京都大学, 医学研究科呼吸器内科, 助教 (00378746)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | II型肺胞上皮細胞 / サーファクタントプロテインC / 上皮間葉移行 / COPD / 気管支喘息 / 気道上皮細胞 / 慢性閉塞性肺疾患 / 末梢気道 |
|---|
| Research Abstract |
By adding appropriate concentration of TGF-β to cultured BEAS-2B cell, the cells exhibited epithelial-mesenchymal transition, which were enhanced by addint TLR-ligands. To perform further experiments on EMT, induced pluripotent stem cells were established from patients with COPD and inducing type II pneumocytes from iPS cells is being tried.
|
