Mechanisms of lung inflammation in tetraspanin-knockout mice
| Project/Area Number |
20590897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
TACHIBANA Isao Osaka University, 医学系研究科, 講師 (60324761)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Yoshito 大阪大学, 医学系研究科, 助教 (40452388)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 閉塞性肺疾患 / テトラスパニン / CD9 / マクロファージ / LPS / 炎症 |
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| Research Abstract |
We previously reported that mice doubly deficient in tetraspanins CD9 and CD81 reveal a phenotype mimicking human COPD, an inflammatory lung disease. In this study, we found that CD9 negatively regulates LPS-induced macrophage activation in vitro and prevents lung inflammation in vivo. Expression of CD9 was decreased in peripheral blood monocytes in patients with COPD. These indicate that CD9 decrease may be a pathogenetic factor to COPD.
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Report
(4 results)
Research Products
(18 results)
