Elucidation of molecular mechanisms of angiogenesis mediated by angiopoietins and its application for asthma therapy

• Project/Area Number: 20590901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka City University
• Principal Investigator: KANAZAWA Hiroshi Osaka City University, 大学院・医学研究科, 准教授 (90332957)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 閉塞性肺疾患 / VEGF / angioPoietin-1 / angiopoietin-2 / 血管新生 / 肺血管内皮細胞 / 肺微小循環系

Research Abstract

Angiopoietin-1 has been shown to protect the adult vasculature against plasma leakage. In contrast, angiopoietin-2, an antagonist of angiopoietin-1, induces loosening of interactions between endothelial and perivascular support cells, and subsequently reduces vascular integrity. Thus, angiopoietin-1 and -2 may play complementary and coordinated roles in airway angiogenesis and microvascular remodeling.

Research Products

• [Journal Article] Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Respir Med 105 Pages: 24-30
  • Peer Reviewed
• [Journal Article] Increased levels of high mobility group box 1 and endogenous secretory receptor for advanced glycation end products in induced sputum from asthmatic patients. (2011)
  • Author(s): Watanabe T, Asai K, Fujimoto H, Tanaka H, Kanazawa H, Hirata K.
  • Journal Title: Respir Med 105 Pages: 519-525
  • Peer Reviewed
• [Journal Article] Gene polymorphism of epidermal growth factor receptor and airway hyperresponsiveness in young allergic subjects without respiratory symptoms. (2011)
  • Author(s): Yoshikawa T, Kanazawa H, Tanaka J, Yamamoto T, Fujimoto S.
  • Journal Title: Med Sci Monit 16
  • Peer Reviewed
• [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma. (2010)
  • Author(s): Kanazawa H, Kyoh S, Asai K, Hirata K.
  • Journal Title: J Asthma 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Increased levels of Nε-(Carboxy methyl) Lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease : a pilot study. (2010)
  • Author(s): Kanazawa H, Kodama T, Asai K, Matsumura S, Hirata K.
  • Journal Title: Clin Sci 119 Pages: 143-149
  • Peer Reviewed
• [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma (2010)
  • Author(s): Kanazawa H, et al.
  • Journal Title: J Asthma Volume: 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Increased levels of Nε-(Carboxymethyl)Lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease : a pilot study (2010)
  • Author(s): Kanazawa H, et al.
  • Journal Title: Clin Sci Volume: 119 Pages: 143-149
  • Peer Reviewed
• [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma (2010)
  • Author(s): Kanazawa H
  • Journal Title: J Asthma 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Increased levels of N^ε-(Carboxymethyl)Lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease (2010)
  • Author(s): Kanazawa H
  • Journal Title: Clin Sci 119 Pages: 143-149
  • Peer Reviewed
• [Journal Article] Increased levels of angiopoietin-2 in induced sputum from smoking a sthmatic patients (2009)
  • Author(s): Kanazawa H
  • Journal Title: Clin Exp Allergy 39 Pages: 1330-1337
  • Peer Reviewed
• [Journal Article] Angiopoietin-2 as a contributing factor in exercise-induced bronchoconstriction in asthmatic patients with inhaled corticosteroid therapy (2008)
  • Author(s): Kanazawa H
  • Journal Title: J Allergy Clin Immunol 121 Pages: 390-395
  • Peer Reviewed
• [Journal Article] Comparison of N^ε-(Carboxymethyl) Lysine levels and percentage of eosinophils in induced sputum for assessment of small airway involvements in asthma (2008)
  • Author(s): Kyoh S
  • Journal Title: Med Sci Monit 14 Pages: 375-380
  • Peer Reviewed
• [Journal Article] Potential roles of pentosidine on age-and disease-related impairment of pulmonary functions in asthmatic patients.
  • Author(s): Kanazawa H, Tochino Y, Ichimaru Y, Kyoh S, Asai K, Hirata K.
  • Journal Title: J Allergy and Clin Immunol in press
  • Peer Reviewed
• [Journal Article] Comparison of alveolar nitric oxide concentrations using two different methods for the assessment of small airways inflammation in asthma.
  • Author(s): Kobayashi D, Tochino Y, Kanazawa H, Ichimaru Y, Kyoh S, Asai K, Hirata K.
  • Journal Title: Respirology in press
  • Peer Reviewed
• [Presentation] COPDにおける気道および肺血管リモデリング (2010)
  • Author(s): 金澤博
  • Organizer: 日本アレルギー学会秋季大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-26
• [Presentation] COPDにおける気道および肺血管リモデリング (2010)
  • Author(s): 金澤博
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(招待講演)
  • Year and Date: 2010-11-26
• [Presentation] JGL2009から見た成人喘息治療 (2010)
  • Author(s): 金澤博
  • Organizer: 日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-05-29
• [Presentation] Mechanisms of corticosteroid resisitance in smoking asthmatic patients : potential roles of angiopoietin-2 (2010)
  • Author(s): 金澤博
  • Organizer: 日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-24
• [Presentation] 誘発喀痰を用いた気道炎症の評価と治療モニタリング (2008)
  • Author(s): 金澤 博
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-13