Co-analysis of multi-gene polymorphisms related to future development of asthma

• Project/Area Number: 20590902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka City University
• Principal Investigator: YOSHIKAWA Takahiro Osaka City University, 大学院・医学研究科, 准教授 (10381998)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 喘息予備軍 / 多遺伝子同時解析 / 気道過敏性

Research Abstract

Airway hyperresponsiveness (AHR) is a hallmark of bronchial asthma. Some of young atopic adults without respiratory symptoms exhibit AHR, and they as well as those with a remission of childhood asthma constitute a possible risk group for adult-onset asthma. The present study raised the possibility that gene polymorphism of epidermal growth factor receptor (EGFR) and protease activated receptor (PAR)-1 might be associated with the formation of these risk groups.

Research Products

• [Journal Article] Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Respir Med. 105 Pages: 24-30
  • Peer Reviewed
• [Journal Article] Characteristics of young atopic adults with self-reported past wheeze and airway hyperresponsiveness. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Allergol Int. (accepted)
  • NAID: 130004873045
  • Peer Reviewed
• [Journal Article] Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. (2011)
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Respir Med. Volume: 105 Pages: 24-30
  • Peer Reviewed
• [Journal Article] Gene polymorphism of epidermal growth factor receptor and airway hyperresponsiveness in young allergic subjects without respiratory symptoms. (2010)
  • Author(s): Yoshikawa T, Kanazawa H, Tanaka J, Fujimoto S, Yamamoto T.
  • Journal Title: Med Sci Monit 16
  • Peer Reviewed
• [Journal Article] Gene polymorphism of epidermal growth factor receptor and airway hyper responsiveness in young allergic subjects without respiratory symptoms (2010)
  • Author(s): Yoshikawa T, Kanazawa H, Tanaka J, Fujimoto S, Yamamoto T
  • Journal Title: Med Sci Monit. 16
  • Peer Reviewed
• [Journal Article] Characteristics of young atopic adults with self-reported past wheeze and airway hyperresponsiveness.
  • Author(s): Yoshikawa T, Kanazawa H.
  • Journal Title: Allergol Int. Volume: (In press)
  • NAID: 130004873045
  • Peer Reviewed
• [Remarks] ホームページ等
  • URL: http://www.med.osaka-cu.ac.jp/sportsmed/
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