| Project/Area Number |
20590903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
YOSHIKAWA Masanori Nara Medical University, 医学部, 准教授 (80271203)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 奈良県立医科大学, 医学部, 教授 (20195374)
TOMODA Koichi 奈良県立医科大学, 医学部, 講師 (90364059)
ANDOH Akira 滋賀医科大学, 医学部, 教授 (90252395)
YAMAMOTO Yoshifumi 奈良県立医科大学, 医学部, 助教 (00458035)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 慢性閉塞性肺疾患 / 全身性炎症 / 肺-消化管ネットワーク / 喫煙 / 腸内環境 / 全身炎症 |
|---|
| Research Abstract |
In smoke exposed animals, food intake and body weight gain were less than those in non-smoking controls while plasma acyl-ghrelin levels were elevated. In addition, the change in bacterial flora and decrease in short chain fatty acids in cecum were found. Supplementation of fiber-free diet resulted in remarkable suppression of body weight gain, deterioration of gut environment and the reduction of serum antioxidant activity. It was shown that discontinuous feeding with fiber-free diet accelerated elastase- induced emphysema in smoke exposed rats, while amount of food intake did not decreased.
These data suggest that deterioration of gut environment by cigarette smoke may contribute to nutritional depletion and systemic inflammation, which in turn may develop the pulmonary emphysema. In conclusion, we have demonstrated an existence of lung-gut network which may be associated with the development of chronic obstructive lung disease.
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