| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
We have proposed the possible pathogenesis of COPD due to loss of tissue repair by lung fibroblasts. The lung fibroblasts from COPD patients had less ability of tissue repair than those from control subjects. In addition, the fibroblasts from COPD patients were sensitive against cigarette smoke extract compared to those from healthy subjects. Toll-like receptor 3 agonist, double-stranded RNA, caused the differentiation of lung fibroblasts into myofibroblasts. These results suggest that lung fibroblasts could be a key cell in the pathogenesis of COPD.
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