Signal transduction molecules associated with the induction and maintenance of airway goblet cell hyperplasia
| Project/Area Number |
20590907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
TAMAOKI Jun Tokyo Women's Medical University, 医学部, 教授 (60147395)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 気管支喘息 / 杯細胞過形成 / 細胞増殖 / ムチン遺伝子 / 上皮細胞成長因子 / 気道過敏性 / 気道リモデリング / 気道上皮 / 杯細胞 / ムチン / シグナル伝達 / 上皮成長因子受容体 / アポトーシス / ERKカスケード / 喘息 / シグナル伝逹 |
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| Research Abstract |
We studied human airway epithelial cells and found that stimulation with TGFα, a ligand of epidermal growth factor receptor (EGFR), increased the expression of genes and proteins of MUC5AC and Bcl-2, and that these effects were inhibited by EGFR and NFκB inhibitors. Furthermore, mucus hypersecretion and airway hyperresponsiveness in the rat model of asthma were attenuated by pretreatment with an EGFR inhibitor. These results suggest that EGFR may play an important role as a signal transduction molecule in airway goblet cell hyperplasia.
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Report
(4 results)
Research Products
(71 results)
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[Book] Airway Secretion Research2009
Author(s)
Tamaoki J, Arai N, Tagaya E, Kondo M, Kawagoe M, Kimura N, Nagai A
Publisher
Japanese Association for Airway Secretion Research
Related Report
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