Role of BCL6 a transcriptional repressor in the pathogenesis of chronic pulmonary inflammatory disease.

• Project/Area Number: 20590913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: ARIMA Masafumi Chiba University, 大学院・医学研究院, 講師 (00202763)
• Co-Investigator(Kenkyū-buntansha): HATANO Masahiko 千葉大学, 大学院・医学研究院, 教授 (20208523)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 気道上皮細胞 / 気道炎症 / 転写因子 / BCL6 / Th2 / Th1サイトカイン / Bcl6 / Th2/Th1サイトカイン / 転写抑制因子 / ケモカイン / ヒストン修飾

Research Abstract

There is synteny in the CC-type chemokine gene clusters between humans (CCL2/MCP-1, CCL7MCP-3, CCL11/Eotaxin, CCL8/MCP-2, CCL13/MCP-4, and CCL1/I-309) and mice (CCL2, CCL7, CCL11, CCL12/MCP-5, CCL8, and CCL1). Since many putative Bcl6/STAT-binding sequences are observed in the clusters, we examined roles of a transcriptional repressor Bcl6 in expression of these chemokine genes in alveolar epithelial cells. We showed that expression of the chemokine genes in the cluster is coordinately repressed by Bcl6 and the airway inflammation is potentially mediated by the chemokines produced by pulmonary epithelium.

Research Products

• [Journal Article] Bcl6 is required for the development of mouse CD4^+ and CD8^+ dendritic cells. (2011)
  • Author(s): Ohtsuka, H., Sakamoto, A., Horigome, S., Ichii, H., Arima, M., Hatano, M., Okada, S., Tokuhisa, T.
  • Journal Title: J Immunol. 186 Pages: 255-263
  • Peer Reviewed
• [Journal Article] Overexpression of the leukotriene C 4 synthase gene in mice reproduces human aspirin-induced asthma. (2011)
  • Author(s): Hirata, H., Arima, M., Fukushima, Y., Honda, K., Tokuhisa , T., Fukuda, T.MD.
  • Journal Title: Clinical & Experimental Allergy. in press.
  • Peer Reviewed
• [Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-21. (2011)
  • Author(s): Yoshida, N., Kitayama, D., Arima, M., Sakamoto, A., Inamine, A., Takano, H., Grusby, M.J., Hatano, M., Koike, T., Tokuhisa.
  • Journal Title: J Immunol. 186 Pages: 2800-2808
  • Peer Reviewed
• [Journal Article] Overexpression of the leukotriene C_4 synthase gene in mice reproduceshuman aspirin-induced asthma. (2011)
  • Author(s): Hirata, H., et al.
  • Journal Title: Clin.Exp.Allergy Volume: 41 In press
  • Peer Reviewed
• [Journal Article] CXCR4 expression on activated B cells is down-regulated by CD63 and IL-21 (2011)
  • Author(s): Yoshida, N., et al.
  • Journal Title: J.Immunol. Volume: 186 Pages: 2800-2808
  • Peer Reviewed
• [Journal Article] Bc16 is required for the development of mouse CD4^+ and CD8^+ dendritic cells. (2011)
  • Author(s): Ohtsuka, H., et al.
  • Journal Title: J.Immunol. Volume: 186 Pages: 255-263
  • Peer Reviewed
• [Journal Article] A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism. (2010)
  • Author(s): Ohta Y.
  • Journal Title: Int J Oncol. 36 Pages: 427-434
  • Peer Reviewed
• [Journal Article] 【CD4+T細胞の機能的亜群への分化】Th2細胞の分化と転写因子(解説/特集) (2009)
  • Author(s): 有馬雅史
  • Journal Title: 臨床免疫・アレルギー科 51 Pages: 462-470
• [Journal Article] Effects of Th2 pulmonary inflammation in mice with bleomycin-induced pulmonary fibrosis. (2008)
  • Author(s): Hirata, H., Arima, M., Fukushima, Y., Ishii, Y., Tokuhisa, T., Fukuda, T.
  • Journal Title: Respirology. 13 Pages: 788-798
  • Peer Reviewed
• [Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21. (2008)
  • Author(s): Kitayama, D., Sakamoto, A., Arima, M., Hatano, M., Miyazaki, M., Tokuhisa, T.
  • Journal Title: Mol Immunol. 45 Pages: 1337-1345
  • Peer Reviewed
• [Journal Article] Effective collaboration between IL-4 and IL-21 on B cell activation. (2008)
  • Author(s): Saito, T., Kitayama, D., Sakamoto, A., Tsuruoka, N., Arima, M., Hatano, M., Miyazaki, M., Tokuhisa, T.
  • Journal Title: Immunobiology. 213 Pages: 545-555
  • Peer Reviewed
• [Journal Article] Effects of Th2 pulmonary inflammation in mice with bleomycin-induced pulmonary fibrosis (2008)
  • Author(s): Hirata H.
  • Journal Title: Respirology 13 Pages: 788-98
  • Peer Reviewed
• [Journal Article] Effective collaboration between IL-4 and IL-21 on B cell activation (2008)
  • Author(s): Saito T.
  • Journal Title: Immunobiology 213 Pages: 545-55
  • Peer Reviewed
• [Journal Article] A role for Bcl6 in sequential class switch recombination to IgE in B cells stimulated with IL-4 and IL-21 (2008)
  • Author(s): Kitayama D.
  • Journal Title: Mol Immunol 45 Pages: 1337-45
  • Peer Reviewed
• [Presentation] A critical role of the intron enhancer element of the IL-4 gene in Th2 cytokine expression. (2010)
  • Author(s): 有馬雅史
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-12-03
• [Presentation] 転写抑制因子BCL6によるアレルギー性炎症の網羅的制御機序 (2010)
  • Author(s): 有馬雅史
  • Organizer: 第60回日本アレルギー学会。(教育講演)
  • Place of Presentation: 東京都
  • Year and Date: 2010-11-25
• [Presentation] 転写抑制因子BCL6によるアレルギー性炎症の網羅的制御機序 (2010)
  • Author(s): 有馬雅史
  • Organizer: 第60回日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] A critical role of the intron enhancer element of the IL-4 gene in Th2 cytokine expression (2009)
  • Author(s): Arima M.
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-12-03
• [Presentation] ヘルパーT細胞Th1/TH2細胞を中心としたその発生分化に迫る:Th2サイトカイン発現に対するIL-4遺伝子イントロンエンハンサーの機能 (2008)
  • Author(s): 有馬雅史
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2008-12-01
• [Presentation] ヘルパーT細胞Th1/Th2細胞を中心としたその発生分化に迫る:Th2サイトカイン発現に対するIL-4遺伝子イントロンエンハンサーの機能 (2008)
  • Author(s): 有馬雅史
  • Organizer: 日本免疫学会総会・学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2008-11-01
• [Remarks] ホームページ等
  • URL: http://www.m.chiba-u.ac.jp/class/devgen/
• [Remarks]
  • URL: http://www.m.chiba-u.ac.jp/class/devgen/