| Project/Area Number |
20590913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Chiba University |
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Principal Investigator |
ARIMA Masafumi Chiba University, 大学院・医学研究院, 講師 (00202763)
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Masahiko 千葉大学, 大学院・医学研究院, 教授 (20208523)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 気道上皮細胞 / 気道炎症 / 転写因子 / BCL6 / Th2 / Th1サイトカイン / Bcl6 / Th2/Th1サイトカイン / 転写抑制因子 / ケモカイン / ヒストン修飾 |
|---|
| Research Abstract |
There is synteny in the CC-type chemokine gene clusters between humans (CCL2/MCP-1, CCL7MCP-3, CCL11/Eotaxin, CCL8/MCP-2, CCL13/MCP-4, and CCL1/I-309) and mice (CCL2, CCL7, CCL11, CCL12/MCP-5, CCL8, and CCL1). Since many putative Bcl6/STAT-binding sequences are observed in the clusters, we examined roles of a transcriptional repressor Bcl6 in expression of these chemokine genes in alveolar epithelial cells. We showed that expression of the chemokine genes in the cluster is coordinately repressed by Bcl6 and the airway inflammation is potentially mediated by the chemokines produced by pulmonary epithelium.
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