To overcome the intractable chronic cough : mechanism of cough and development of therapy

• Project/Area Number: 20590916
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: FUJIMURA Masaki Kanazawa University, 医学系, 准教授 (90190066)
• Co-Investigator(Kenkyū-buntansha): KATAYAMA Nobuyuki 金沢大学, 附属病院, 助教 (30334767) ; OGAWA Haruhiko 金沢大学, 医学系, 協力研究員 (70401908)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 慢性咳嗽 / 難治性 / 咳嗽発生機序 / 知覚神経 / 平滑筋収縮 / 平滑筋

Research Abstract

It has been disclosed that there are at least two pathway of cough reflex : (1) increased cough receptor sensitivity (atopic cough) or hyper-stimulation to cough receptors (sinobronchial syndrome) which are present in inter- and sub epithelium of airway, (2) increased response of sensory nerve endings (Adelta-fibers) in intra- and peri-smooth muscle layer to the smooth muscle contraction (cough variant asthma) or hyper-stimulation (strong smooth muscle contraction) to the nerve endings.

Research Products

• [Journal Article] Gender differences in chronic cough. (2011)
  • Author(s): 藤村政樹
  • Journal Title: Current Respiratory Medicine Reviews 7 in press
  • Peer Reviewed
• [Journal Article] Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs (2011)
  • Author(s): Hori A, Fujimura M, Ohkura N, Tokuda A
  • Journal Title: Cough Volume: in press
  • NAID: 120003913342
  • Peer Reviewed
• [Journal Article] Ventilatory impairment detection based on distribution of respiratory-induced changes in pixel values in dynamic chest radiography : a feasibility study. (2010)
  • Author(s): Tanaka R, Sanada S, Fujimura M
  • Journal Title: Int J Comput Assist Radiol Surg.
  • Peer Reviewed
• [Journal Article] 慢性咳嗽を診る:症例から学ぶ (2010)
  • Author(s): 藤村政樹編集
  • Journal Title: 医薬ジャーナル社、大阪市(改訂版)
• [Journal Article] Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with chronic bronchitis. (2010)
  • Author(s): Ishiura Y, Fujimura M, et al
  • Journal Title: Cough 6 Pages: 7-7
  • Peer Reviewed
• [Journal Article] Effects of Macrolides on Antigen-Induced Increases in Cough Reflex Sensitivity in Guinea Pigs. (2010)
  • Author(s): Tokuda A, Ohkura N, Fujimura M, et al
  • Journal Title: Pulm Pharmacol Ther 23 Pages: 55-61
  • NAID: 120002061088
  • Peer Reviewed
• [Journal Article] Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. (2010)
  • Author(s): Kita T, Fujimura M, et al
  • Journal Title: Allergol Int. 59 Pages: 185-192
  • NAID: 10029670343
  • Peer Reviewed
• [Journal Article] Bronchoconstriction-triggered cough is impaired in typical asthmatics. (2010)
  • Author(s): Ohkura N, Fujimura M, et al
  • Journal Title: J Asthma 47 Pages: 51-54
  • Peer Reviewed
• [Journal Article] Airway wall structure assessed by endobronchial ultrasonography and bronchial hyperresponsiveness in patients with asthma (2010)
  • Author(s): Kita T, Fujimura M, Kurimoto N, Sone T, Inuzuka K. Hirose T, Oribe Y, Myou S, Nakao S
  • Journal Title: J Bronchol Intervent Pulmonol Volume: 17 Pages: 301-305
  • NAID: 120002772010
  • Peer Reviewed
• [Journal Article] Do beta(2)-agonists inhibit capsaicin-induced cough? (2010)
  • Author(s): Ohkura N, Fujimura M, Tokuda A, Katayama N
  • Journal Title: Eur Respir J Volume: 36 Pages: 459-460
  • Peer Reviewed
• [Journal Article] Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with chronic bronchitis (2010)
  • Author(s): Ishiura Y, Fujimura M, Yamamoto H, Ohkura N, Myou S
  • Journal Title: Cough Volume: 6,7(Online)
  • Peer Reviewed
• [Journal Article] Effects of Macrolides on Antigen-Induced Increases in Cough Reflex Sensitivity in Guinea Pig (2010)
  • Author(s): Tokuda A, Ohkura N, Fujimura M, Furusho S, Abo M, Katayama N
  • Journal Title: Pulm Pharmacol Ther Volume: 23 Pages: 55-61
  • NAID: 120002061088
  • Peer Reviewed
• [Journal Article] Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopiccough (2010)
  • Author(s): Kita T, Fujimura M, Myou S, Nishi K, Shirasaki H, Ogawa H, Ishimura Y, Nakao S
  • Journal Title: Allergoi Int Volume: 59 Pages: 185-192
  • Peer Reviewed
• [Journal Article] Bronchoconstriction-triggered cough is impaired in typicalasthmatics (2010)
  • Author(s): Ohkura N, Fujimura M, Tokuda A, Nakade Y, Nishitsuji M, Abo M, Katayama N
  • Journal Title: J Asthma Volume: 47 Pages: 51-54
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 藤村政樹
  • Journal Title: Annual Review 2010呼吸器(永井厚志、巽浩一郎、桑野和善、高橋和久編集)(中外医学社) Pages: 74-78
• [Journal Article] Evaluation of airway hyperresponsiveness and exhaled nitric oxide as risk factors for airway remodeling in patients with stable asthma. (2009)
  • Author(s): Ohkura N, Fujimura M, et al
  • Journal Title: Allergy and Asthma Proc 30 Pages: 419-423
  • Peer Reviewed
• [Journal Article] Bronchodilator effect of deep inspiration and bronchoconstriction-triggered cough. (2009)
  • Author(s): Ohkura N, Fujimura M, et al
  • Journal Title: Cough 5 Pages: 9-9
  • Peer Reviewed
• [Journal Article] The importance of basidiomycetous fungi cultured from the sputum of chronic idiopathic cough. (2009)
  • Author(s): Ogawa H, Fujimura M, et al
  • Journal Title: Respir Med 103 Pages: 1492-1497
  • Peer Reviewed
• [Journal Article] Is Bjerkandera adusta important to fungus-associated chronic cough (FACC) as an allergen (2009)
  • Author(s): Ogawa H, Fujimura M, et al
  • Journal Title: Eight cases'report.J Asthma 46 Pages: 849-855
  • Peer Reviewed
• [Journal Article] COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. (2009)
  • Author(s): Ishiura Y, Fujimura M, et al
  • Journal Title: J Investig Allergol Clin Immunol 19 Pages: 370-374
  • Peer Reviewed
• [Journal Article] Additional effects of pranlukast on exhaled nitric oxide levels in patients with persistent asthma. (2009)
  • Author(s): Ohkura N, Fujimura M, et al
  • Journal Title: Ther Res 30 Pages: 1361-1366
  • Peer Reviewed
• [Journal Article] Efficacy of itraconazole in the treatment of patients with chronic cough whose sputa yield basidiomycetous fungi : fungus-associated chronic cough (FACC). (2009)
  • Author(s): Ogawa H, Fujimura M, et al
  • Journal Title: J Asthma 46 Pages: 407-412
  • Peer Reviewed
• [Journal Article] Bronchoconstriction-triggered cough in conscious guinea pigs. (2009)
  • Author(s): Ohkura N, Fujimura M
  • Journal Title: Exp Lung Res 35 Pages: 296-306
  • Peer Reviewed
• [Journal Article] Bronchoconstriction-triggered cough in conscious guinea pigs (2009)
  • Author(s): Ohkura N, Fujimura M, 他4名
  • Journal Title: Exp Lung Res 35 Pages: 296-306
  • Peer Reviewed
• [Journal Article] Efficacy of itraconazole in the treatment of patients with chronic cough whose sputa yield basidiomycetous fungi : fungus-associated chronic cough(FACC) (2009)
  • Author(s): Ogawa H, Fujimura M, 他2名
  • Journal Title: J Asthma 46 Pages: 407-412
  • Peer Reviewed
• [Journal Article] Effect of KF19514, a phosphodiesterase 4 and 1 inhibitor, on bronchial inflammation and remodeling in murine chronic asthma (2009)
  • Author(s): Kita T, Fujimura M, 他7名
  • Journal Title: Allergol Int 58 Pages: 267-275
  • Peer Reviewed
• [Journal Article] Exhaled nitric oxide (NO) levels in patients with atopic cough and cough variant asthma (2008)
  • Author(s): Fujimura M, 他5名
  • Journal Title: Respirology 13 Pages: 359-364
  • NAID: 120001135522
  • Peer Reviewed
• [Journal Article] Effect of an orally active Th2 cytokine inhibitor, suplatast tosilate, on "atopic cough (2008)
  • Author(s): Ishiura Y, Fujimura M, 他5名
  • Journal Title: Arzneim Forsch/Drug Research 58 Pages: 297-302
  • Peer Reviewed
• [Journal Article] Sputum eosinophilia, airway hyperresponsiveness and airway narrowing in young adults with former asthma (2008)
  • Author(s): Hara J, Fujimura M, 他9名
  • Journal Title: Allergol Int. 57 Pages: 211-217
  • NAID: 10024419767
  • Peer Reviewed
• [Journal Article] Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs.
  • Author(s): Hori A, Fujimura M, et al
  • Journal Title: Cough 2010 in press
  • NAID: 120003913342
  • Peer Reviewed
• [Presentation] Pathophysiology of atopic cough in comparison with cough variant asthma. (2010)
  • Author(s): Fujimura M
  • Organizer: Sino-Japan Specialist Seminar on Cough 2010
  • Place of Presentation: International Congress Center, Shanghai, China(招請講演)
  • Year and Date: 2010-05-29
• [Presentation] Atopic cough (2010)
  • Author(s): Fujimura M
  • Organizer: Sino-Japan Specialist Seminar on Cough
  • Place of Presentation: China/Oriental Riverside Hotel, Pudong, Shanghai
  • Year and Date: 2010-05-28
• [Presentation] 喘息:病態の既知と未知 (2010)
  • Author(s): 藤村政樹
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都府/国立京都国際会館
  • Year and Date: 2010-05-08
• [Presentation] Cough sensitivity, airway responsiveness and exhaled nitric acid (eNO) for predicting the response to bronchodilator therapy (BDT) in patients with chronic non-productive cough. (2010)
  • Author(s): Fujimura M, Tokuda A, Ohkura N.
  • Organizer: 20^<th> ERS Annual Congress
  • Place of Presentation: International Convention Center, Barcelona, Spain
• [Presentation] Usefulness of the self-powered audio device (Lung Flute) for sputum production in patients with nonproductive cough. (2010)
  • Author(s): Tokuda A, Ohkura N, Furusho S, Nishitsuji M, Abo M, Katayama N, Fujimura M.
  • Organizer: 20^<th> ERS Annual Congress
  • Place of Presentation: International Convention Center, Barcelona, Spain
• [Presentation] 小児から成人へ、上気道から下気道へ (2009)
  • Author(s): 藤村政樹
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 長良川国際会議場 岐阜都ホテル(岐阜県)
  • Year and Date: 2009-06-05
• [Presentation] Bronchoconstriction-triggered cough is impaired in typical asthmatics. (2009)
  • Author(s): Ohkura N, Fujimura M, Tokuda A, Nakade, Nishitsuji M, Abo M, Katayama N.
  • Organizer: 19th ERS Annual Congress
  • Place of Presentation: Messe Wien, Vienna
• [Presentation] Modulating effect of carbocysteine on the membrane expression of Toll-like receptor 4 on human bronchial epithelial cells. (2009)
  • Author(s): Tokuda A, Katayama N, Ohkura N, Furusho S, Abo M, Fujimura M.
  • Organizer: 19th ERS Annual Congress
  • Place of Presentation: Messe Wien, Vienna
• [Presentation] Cough in the Asia Pacific region Eosinophilic bronchitis : Prevalence and long-term outcomes (2008)
  • Author(s): Fujimura M
  • Organizer: 13th Congress for the Asian Pacific Society of Respi rology
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-11-22
• [Presentation] Symposium "Cough in the Asia Pacific region". Eosinophilic bronchitis : Prevalence and long-term outcomes. (2008)
  • Author(s): Fujimura M.
  • Organizer: 13th Congress for the Asian Pacific Society of Respirology
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
  • Year and Date: 2008-11-19
• [Presentation] Predictors of efficacy of bronchodilator therapy for chronic non-productive cough : cough reflex sensitivity, exhaled nitric oxide, bronchial responsiveness (2008)
  • Author(s): Fujimura M, Ohkura N, Abo M, Furusho S, Waseda Y.
  • Organizer: 18th ERS Annual Congress
  • Place of Presentation: International Congress Center, Berlin
• [Presentation] Causes of chronic cough in patients with interstitial pneumonia. (2008)
  • Author(s): Waseda Y, Yasui M, Inuzuka K, Takato H, Ichikawa Y, Nishizawa Y, Fujimura M.
  • Organizer: 18th ERS Annual Congress
  • Place of Presentation: International Congress Center, Berlin
• [Presentation] Bronchial responsiveness and chronic non-productive cough responding to bronchodilator therapy. (2008)
  • Author(s): Abo M, Fujimura M, Ohkura N, Waseda Y.
  • Organizer: 18th ERS Annual Congress
  • Place of Presentation: International Congress Center, Berlin
• [Presentation] Airway hyperresponsiveness, but not exhaled nitric oxide, as a risk factor for decline in post-bronchodilator FEV1 in patients with stable asthma. (2008)
  • Author(s): Ohkura N, Fujimura M, Tokuda A, Katayama N, Abo M, Nakao S.
  • Organizer: 18th ERS Annual Congress
  • Place of Presentation: International Congress Center, Berlin
• [Presentation] Symposium "Cough in the Asia Pacific region" Eosinophilic bronchitis (2008)
  • Author(s): Fujimura M
  • Organizer: Prevalence and long-term outcomes 13th Congress for the Asian Pacific Society of Respirology
  • Place of Presentation: Queen Sirikit National Convention Center, Bangkok, Thailand
• [Book] 診療ガイドダイジェスト(慢性咳嗽)(前沢政次、坂東浩編集) (2011)
  • Author(s): 藤村政樹
  • Publisher: 南山堂、東京
• [Book] 咳喘息の診断・治療の意義を探る(気管支喘息治療の新たなストラテジー 大田健編集) (2011)
  • Author(s): 藤村政樹
  • Publisher: 先端医学社、東京
• [Book] 咳喘息.総合アレルギー学(2版) (2010)
  • Author(s): 藤村政樹
  • Publisher: 南山堂、東京
• [Book] 気道過敏症.総合アレルギー学(2版) (2010)
  • Author(s): 藤村政樹
  • Publisher: 南山堂、東京
• [Book] 咳と痰の臨床-内科/耳鼻科/小児科領域から-(内科領域:乾性咳嗽:咳喘息・アトピー咳嗽)(三嶋理晃編集) (2010)
  • Author(s): 藤村政樹
  • Publisher: 医薬ジャーナル社、大阪市
• [Book] ガイドライン/ガイダンス咳嗽こう診る・こう考える(遷延性咳嗽と慢性咳嗽について-総論)(石田直編集) (2010)
  • Author(s): 藤村政樹
  • Publisher: 日本医事新報社、東京
• [Book] 診療ガイドラインUP-TO-DATE2010-2011(咳嗽)(門脇孝、小室一成、宮地良樹監修) (2010)
  • Author(s): 藤村政樹
  • Publisher: メディカルレビュー社、大阪
• [Book] 慢性咳嗽を診る:症例から学ぶ(総論:診断に役立つ検査-呼吸機能検査)(藤村政樹編集)(改訂版) (2010)
  • Author(s): 藤村政樹
  • Publisher: 医薬ジャーナル社、大阪市
• [Book] 慢性咳嗽を診る:症例ら学ぶ(総論:慢性咳嗽の定義と基礎病態)(藤村政樹編集)(改訂版) (2010)
  • Author(s): 藤村政樹
  • Publisher: 医薬ジャール社、大阪市
• [Book] Annual Review 2010呼吸器(遷延性咳)(永井厚志、巽浩一郎、桑野和善、高橋和久編集) (2010)
  • Author(s): 藤村政樹
  • Publisher: 中外医学社、東京
• [Book] 改訂版 慢性咳漱を診る:症例から学ぶ 藤村政樹編集 (2010)
  • Author(s): 藤村政樹
  • Total Pages: 275
  • Publisher: 医薬ジャーナル社
• [Book] 診療ガイドラインUP-TO-DATE 2010-2011 (2010)
  • Author(s): 藤村政樹
  • Publisher: メディカルレビュー社、大阪
• [Book] 呼吸器系症状と検査異常A症状・所見:咳嗽、喘鳴.(チャート内科診断学富野康日己編集) (2009)
  • Author(s): 藤村政樹
  • Publisher: 中外医学社東京
• [Book] 別冊日本臨床:呼吸器症候群(第2版)II.(慢性咳嗽) (2009)
  • Author(s): 藤村政樹
  • Publisher: 日本臨床社、大阪
• [Book] 別冊日本臨床:呼吸器症候群(第2版)II.(アトピー咳嗽(非喘息性好酸球性気管支炎).) (2009)
  • Author(s): 藤村政樹
  • Publisher: 日本臨床社、大阪
• [Book] 別冊 日本臨床 : 呼吸器症候群(第2版)II (2009)
  • Author(s): 藤村政樹
  • Publisher: 日本臨床社
• [Book] 呼吸器:慢性咳嗽(2ページで解説:診療ガイドダイジェスト)(前沢政次、板東浩編) (2008)
  • Author(s): 藤村政樹
  • Publisher: 南山堂、東京