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the research related to the pathogenesis and novel treatment of pulmonary hypertension making use of genetically-modified mouse

Research Project

Project/Area Number 20590920
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionMie University

Principal Investigator

MARUYAMA Junko  Mie University, 医用工学部, 教授 (50263017)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Kazuo  三重大学, 大学院・医学系研究科, 教授 (20181828)
GABAZZA Esteban (ガバザ エステバン)  三重大学, 大学院・医学系研究科, 教授 (00293770)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炎症 / 右室肥大 / 肺胞洗浄 / モノクロタリン / CD4 / CD8 / 肺高血圧症 / 低酸素 / マウス / 肺血管
Research Abstract

To study the role of CD4/CD8 T cell in the pathogenesis of pulmonary hypertension (PH), the severity of lung inflammation and right ventricular hypertrophy(RVH) was evaluated in monocrotaline(MCT)-induced CD4- or CD8- deficient mice as well as wild-type mice. The inflammation responses in lung were observed in all MCT-induced groups, however, RVH were only observed in wild -type mice, not CD4- nor CD8- deficient mice. From all these results, CD4 and CD8 T cell groups might be associated with the development of pulmonary hypertension.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Book (1 results)

  • [Journal Article] 肺循環・肺高血圧を識る-診断・治療の現在-2011

    • Author(s)
      丸山一男、丸山淳子
    • Journal Title

      Heart View

      Volume: 15 Pages: 74-79

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Effect of all-trans-retinoic acid on the development of chronic hypoxia-induced pulmonary hypertension.2010

    • Author(s)
      Zhang E, Jiang B, Yokochi A, Maruyama J, Mitani Y, Ma N, Maruyama K
    • Journal Title

      Circ J. 74(8)

      Pages: 1696-1703

    • NAID

      10026566030

    • Related Report
      2010 Final Research Report
  • [Journal Article] Colforsin-induced vasodilation in chronic hypoxic pulmonary hypertension in rats.2010

    • Author(s)
      Yokochi A, Itoh H, Maruyama J, Zhang E, Jiang B, Mitani Y, Hamada C, Maruyama K.
    • Journal Title

      J Anesth. 24(3)

      Pages: 432-440

    • NAID

      10026545645

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of all-trans-retinoic acid on the development of chronic hypoxia-induced pulmonary hypertension.2010

    • Author(s)
      丸山淳子、丸山一男, 他
    • Journal Title

      Circ J.

      Volume: 74 Pages: 1696-703

    • NAID

      10026566030

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colforsin-induced vasodilation in chronic hypoxic pulmonary hypertension in rats.2010

    • Author(s)
      丸山淳子、丸山一男, 他
    • Journal Title

      J Anesth

      Volume: 24 Pages: 432-40

    • NAID

      10026545645

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Colforsin-induced asodilation in chronic hypoxic pulmonary hypertension in rats2010

    • Author(s)
      Yokochi A, Itoh, H, Maruyama J., Zhang E, Jiang BH, Mitani Y., Hamada C, Maruyama K
    • Journal Title

      J Anesth (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo plaque composition and morphology in coronary artery lesions in adolescents and young adults long after Kawasaki disease : a virtual histology-intravascular ultrasound study.2009

    • Author(s)
      Mitani Y, Ohashi H, Sawada H, Ikeyama Y, Hayakawa H, Takabayashi S, Maruyama K, Shimpo H, Komada Y.
    • Journal Title

      Circulation 119(21)

      Pages: 2829-2836

    • Related Report
      2010 Final Research Report
  • [Journal Article] Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit.2009

    • Author(s)
      Nakamura A, Wada H, Ikejiri M, Hatada T, Sakurai H, Matsushima Y, Nishioka J, Maruyama K, Isaji S, Takeda T, Nobori T.
    • Journal Title

      Shock. 31(6)

      Pages: 586-591

    • Related Report
      2010 Final Research Report
  • [Journal Article] In vivo plaque composition and morphology in coronary artery lesions in adolescents and young adults long after Kawasaki disease : a virtual histology-intravascular ultrasound study2009

    • Author(s)
      Mitani Y, Ohashi H, Sawada H, Ikeyama Y, Hayakawa H, Takabayashi S, Maruyama K, Shimpo H, Komada Y
    • Journal Title

      Circulation 119

      Pages: 2829-36

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats.2008

    • Author(s)
      丸山淳子, 丸山一男, 他
    • Journal Title

      J Thorac Cardiovasc Surg 136

      Pages: 142-149

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit

    • Author(s)
      丸山一男, 他
    • Journal Title

      Shock (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス肺高血圧症モデルにおける組織学的重症度の評価方法の検討2010

    • Author(s)
      丸山淳子
    • Organizer
      第57回日本麻酔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス慢性肺高血圧症モデルにおける組織学的重症度の評価方法の検討2010

    • Author(s)
      丸山淳子、丸山一男, 他
    • Organizer
      日本麻酔学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] モノクロタリン(MCT)誘発性肺高血圧症(PH)発症におけるT細胞の関与2009

    • Author(s)
      丸山淳子
    • Organizer
      第56回日本麻酔科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-16
    • Related Report
      2010 Final Research Report
  • [Presentation] モノクロタリン誘発生肺高血圧発症におけるT細胞の関与2009

    • Author(s)
      丸山淳子, 丸山一男, 他
    • Organizer
      第56回日本麻酔学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modulation of age in th everity of inflammation and coagulation profile in rat monocrotaline-induced pulmonary hypertension2008

    • Author(s)
      丸山淳子
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of Age in the Severity of Inflammation and Coagulation Profile in Rat Monocrotaline-Induced Pulmonary Hypertension2008

    • Author(s)
      丸山一男, 他
    • Organizer
      アメリカ胸部疾患学会
    • Place of Presentation
      カナダ トロント
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] The effects of thrombin-activable fibrinolysis inhibitor on the inflammatory changes in monocrotaline-induced pulmonary hypertension2008

    • Author(s)
      丸山淳子
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] The Effects of Thrombin-activatable Fibrinolysis Inhibitor on the Inflammatory Changes in Monocrotaline -induced Pulmonary Hypertension2008

    • Author(s)
      丸山淳子, 他
    • Organizer
      アメリカ胸部疾患学会
    • Place of Presentation
      カナダ トロント
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Book] 人工呼吸の考え方2009

    • Author(s)
      丸山一男
    • Total Pages
      271
    • Publisher
      南江堂
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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