| Project/Area Number |
20590921
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
CHIN Kazuo Kyoto University, 大学院・医学研究科, 教授 (90197640)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGA Toru 京都大学, 大学院・医学研究科, 講師 (90378670)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 閉塞型睡眠時無呼吸 / 血小板凝集能 / 持続的低酸素 / 間欠的低酸素 / 心血管障害 / HIF-1 / メタボリック症候群 / 睡眠時睡眠時無呼吸 / 持続気道陽圧 |
|---|
| Research Abstract |
We showed that platelet aggregability was increased in patients with moderate-to-severe obstructive sleep apnea (OSA) partly through an intermittent hypoxia and reoxygenation phenomenon, which is pathophysiologically characteristic of OSA. As the effects of the severity of OSA on platelet aggregability were stronger in patients with vascular risk factors, the co-existence of OSA should be examined for the treatment of patients with multiple risk factors. Continuous therapy with continuous positive airway pressure (CPAP) improved platelet aggregability at 90 days. Thus, one of the reasons for the increase in cardiovascular events in OSA could be increased platelet aggregability. Under the hypoxic conditions which were induced by our machine, intermittent hypoxia induced TNF-α、and sustained hypoxia induced hypoxia inducible factor-1 (HIF-1) in HeLa cells.
|
