Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.
| Project/Area Number |
20590921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
CHIN Kazuo Kyoto University, 大学院・医学研究科, 教授 (90197640)
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| Co-Investigator(Kenkyū-buntansha) |
OGA Toru 京都大学, 大学院・医学研究科, 講師 (90378670)
HORIUCHI Hisanori 東北大学, 加齢研究所, 教授 (90291426)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 閉塞型睡眠時無呼吸 / 血小板凝集能 / 持続的低酸素 / 間欠的低酸素 / 心血管障害 / HIF-1 / メタボリック症候群 / 睡眠時睡眠時無呼吸 / 持続気道陽圧 |
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| Research Abstract |
We showed that platelet aggregability was increased in patients with moderate-to-severe obstructive sleep apnea (OSA) partly through an intermittent hypoxia and reoxygenation phenomenon, which is pathophysiologically characteristic of OSA. As the effects of the severity of OSA on platelet aggregability were stronger in patients with vascular risk factors, the co-existence of OSA should be examined for the treatment of patients with multiple risk factors. Continuous therapy with continuous positive airway pressure (CPAP) improved platelet aggregability at 90 days. Thus, one of the reasons for the increase in cardiovascular events in OSA could be increased platelet aggregability. Under the hypoxic conditions which were induced by our machine, intermittent hypoxia induced TNF-α、and sustained hypoxia induced hypoxia inducible factor-1 (HIF-1) in HeLa cells.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Associations between obstmctive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan.2010
Author(s)
Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Importance of PaCO2 level a few months after initiation of long-term NPPV.2010
Author(s)
Tsuboi T, Oga T, Machida K, Chihara Y, Harada Y, Niimi A, Handa T, Takahashi K, Ohi M, Mishima M, Chin K.
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Journal Title
Respiratory Medison
Volume: 104
Pages: 1850-1857
Related Report
Peer Reviewed
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[Journal Article] Noninvasive ventilation improves the outcomes of pulmonary complications after liver resection.2010
Author(s)
Narita M, Tanizawa K, Chin K, Handa T, Oga T, Niimi A, Tsuboi T, Ikai I, Mishima M, Uemoto S, Hatano E.
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Journal Title
Internal Medicine
Volume: 49
Pages: 1501-1507
NAID
Related Report
Peer Reviewed
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[Journal Article] Avoidance of reintubation by using sedation during noninvasive positive pressure ventilation in a 3-month-old infant with postoperative respiratory failure.2010
Author(s)
Watanabe K, Chin K, Takahashi K, Murata M, Doi H, Handa T, Toru Oga, Tsuboi T, Ikeda T, Nakahata T, Sakata R, Mishima M.
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Journal Title
Internal Medicine
Volume: 49
Pages: 1159-1162
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009
Author(s)
Oga T, Chin K, Tabuchi A, Sumi K, Takahashi K,Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M'Morimoto T, Mishima M, Kita T, Horiuchi H
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Journal Title
Journal of Atheroclerosis and Thrombosis 16
Pages: 862-869
NAID
Related Report
Peer Reviewed
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[Journal Article] Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kumura H, Ohi M, Fukuhara S.Simple fourvariable screening tool for identification of patients with-disordered breathing.2009
Author(s)
Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kumura H, Ohi M, Fukuhara S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea befbre and after nasal CPAP treatment.2008
Author(s)
Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M.
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Journal Title
Respirology 13
Pages: 810-816
Related Report
Peer Reviewed
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[Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008
Author(s)
Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
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Journal Title
Antioxtdemts & Redox signeding 10
Pages: 715-726
Related Report
Peer Reviewed
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[Journal Article] Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness.
Author(s)
Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka, Y,Wakamura T, Fukuhara S, Mishima M, Kadotani H.
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Journal Title
Journal of Sleep Rrsecrch in press
Related Report
Peer Reviewed
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[Journal Article] Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness.
Author(s)
Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka, Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H.
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Journal Title
Journal of Sleep Rrsearch
Volume: (in press)
Related Report
Peer Reviewed
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