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Effects of obstructive sleep apnea with intermittent and sustained hypoxia on platelet aggregability and adipocyte.

Research Project

Project/Area Number 20590921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyoto University

Principal Investigator

CHIN Kazuo  Kyoto University, 大学院・医学研究科, 教授 (90197640)

Co-Investigator(Kenkyū-buntansha) OGA Toru  京都大学, 大学院・医学研究科, 講師 (90378670)
HORIUCHI Hisanori  東北大学, 加齢研究所, 教授 (90291426)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords閉塞型睡眠時無呼吸 / 血小板凝集能 / 持続的低酸素 / 間欠的低酸素 / 心血管障害 / HIF-1 / メタボリック症候群 / 睡眠時睡眠時無呼吸 / 持続気道陽圧
Research Abstract

We showed that platelet aggregability was increased in patients with moderate-to-severe obstructive sleep apnea (OSA) partly through an intermittent hypoxia and reoxygenation phenomenon, which is pathophysiologically characteristic of OSA. As the effects of the severity of OSA on platelet aggregability were stronger in patients with vascular risk factors, the co-existence of OSA should be examined for the treatment of patients with multiple risk factors. Continuous therapy with continuous positive airway pressure (CPAP) improved platelet aggregability at 90 days. Thus, one of the reasons for the increase in cardiovascular events in OSA could be increased platelet aggregability. Under the hypoxic conditions which were induced by our machine, intermittent hypoxia induced TNF-α、and sustained hypoxia induced hypoxia inducible factor-1 (HIF-1) in HeLa cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (60 results)

All 2011 2010 2009 2008 Other

All Journal Article (26 results) (of which Peer Reviewed: 22 results) Presentation (25 results) Book (8 results) Remarks (1 results)

  • [Journal Article] Immediate noninvasive ventilation may improve mortality in patients with hepatopulmonary syndrome after liver transplantation.2011

    • Author(s)
      Chihara Y, Egawa H, Tsuboi T, Oga T, Handa T,Yamamoto K, Mishima M Tanaka K, Uemoto S, Chink K.
    • Journal Title

      Liver, Trensplemtetion 17

      Pages: 144-148

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term nasal contlnuous posltlve alrway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless ofage.2010

    • Author(s)
      Aihara K, Chin K, Oga T. Takahashi K, Hitomi T, Takegami M, Handa T, Niimi A, Tsuboi T, Mishima M.
    • Journal Title

      Hypertension Resecrch 33

      Pages: 1025-1031

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations between obstmctive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan.2010

    • Author(s)
      Chin K, Oga T, Takahashi K, Takegami M, Nakayama-Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H.
    • Journal Title

      Sleep 33

      Pages: 89-95

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of PaCO2 level a few months after initiation of long-term NPPV.2010

    • Author(s)
      Tsuboi T, Oga T, Machida K, Chihara Y, Harada Y, Niimi A, Handa T, Takahashi K, Ohi M, Mishima M, Chin K.
    • Journal Title

      Respiratory Medison

      Volume: 104 Pages: 1850-1857

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term nasal continuous positive airway pressure treatment lowers blood pressure in patients with obstructive sleep apnea regardless of age.2010

    • Author(s)
      Aihara K, Chin K, Oga T, Takahashi K, Hitomi T, Takegami M, Handa T, Niimi A, Tsuboi T, Mishima M.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 1025-1031

    • NAID

      10027475257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive ventilation improves the outcomes of pulmonary complications after liver resection.2010

    • Author(s)
      Narita M, Tanizawa K, Chin K, Handa T, Oga T, Niimi A, Tsuboi T, Ikai I, Mishima M, Uemoto S, Hatano E.
    • Journal Title

      Internal Medicine

      Volume: 49 Pages: 1501-1507

    • NAID

      130000299569

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Avoidance of reintubation by using sedation during noninvasive positive pressure ventilation in a 3-month-old infant with postoperative respiratory failure.2010

    • Author(s)
      Watanabe K, Chin K, Takahashi K, Murata M, Doi H, Handa T, Toru Oga, Tsuboi T, Ikeda T, Nakahata T, Sakata R, Mishima M.
    • Journal Title

      Internal Medicine

      Volume: 49 Pages: 1159-1162

    • NAID

      130000251646

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of non-invasive ventilation for life-threatening asthma attacks : Changes in the need for intubation.2010

    • Author(s)
      Murase K, Tomii K, Chin K, TsuboiT, Sakurai A, Tachikawa R, Harada Y, Takeshima Y, Hayashi M, Ishihara K.
    • Journal Title

      Respirology

      Volume: 15 Pages: 714-720

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations between obstructive sleep apnea, metabolic syndrome and sleep duration, as measured with an actigraph, in an urban male working population in Japan.2010

    • Author(s)
      Chin K, Oga T, 他12名
    • Journal Title

      Sleep 36

      Pages: 89-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009

    • Author(s)
      Oga T, Chin K, Tabuchi A, Sumi K, Takahashi K,Handa T, Takahashi K, Taniguchi R, Kondo H, Kawato M'Morimoto T, Mishima M, Kita T, Horiuchi H
    • Journal Title

      Journal of Atheroclerosis and Thrombosis 16

      Pages: 862-869

    • NAID

      130004444357

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.2009

    • Author(s)
      Oga T, Chin K Horiuchi H, 他11名
    • Journal Title

      Journal of Atherosclerosis and Thrombosis 16

      Pages: 862-869

    • NAID

      130004444357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kumura H, Ohi M, Fukuhara S.Simple fourvariable screening tool for identification of patients with-disordered breathing.2009

    • Author(s)
      Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kumura H, Ohi M, Fukuhara S.
    • Journal Title

      Sleep 32

      Pages: 939-948

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠時無呼吸症候群(SAS)の診断, 特集 : 睡眠呼吸障害と循環器疾患2009

    • Author(s)
      陳和夫
    • Journal Title

      Cardiac Practice 20

      Pages: 41-45

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 睡眠時無呼吸症候群・肥満低換気症候群. 特集 : 肥満-最新の基礎・臨床研究-2009

    • Author(s)
      陳和夫
    • Journal Title

      日本臨床 67

      Pages: 350-355

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 序論. 特集 : 睡眠時無呼吸-最近の進歩と展望-2009

    • Author(s)
      陳和夫
    • Journal Title

      最新医学 64

      Pages: 5-6

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 社会生活と予後に大きな影響を与える重要な病態, 特集 : 睡眠時無呼吸-最近の進歩と展望-2009

    • Author(s)
      陳和夫
    • Journal Title

      最新医学 64

      Pages: 7-13

    • NAID

      40016429970

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea befbre and after nasal CPAP treatment.2008

    • Author(s)
      Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M.
    • Journal Title

      Respirology 13

      Pages: 810-816

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008

    • Author(s)
      Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M.
    • Journal Title

      Antioxtdemts & Redox signeding 10

      Pages: 715-726

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure.2008

    • Author(s)
      Takahashi K, Chin K, Nakamura H, 他8名
    • Journal Title

      Antioxidants & Redox Signaling 10

      Pages: 715-726

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acylated ghrelin level in patients with obstructive sleep apnoea before and after nasal CPAP treatment.2008

    • Author(s)
      Takahashi K, Chin K, 他10名
    • Journal Title

      Repirology 13

      Pages: 810-816

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep-disordered breathing in the usul lifestyle setting as detected with home monitoring in a Japanese male working population.2008

    • Author(s)
      Nakayama-Ashida Y, Takegami M, Chin K, 他9名
    • Journal Title

      Sleep 31

      Pages: 419-425

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computed Tomography analysis of airway dimensions and lung density in patients with sarcoidosis.2008

    • Author(s)
      Handa T, Nagai S, Hirai T, Chin K, 他9名
    • Journal Title

      Respiration 77

      Pages: 273-281

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness.

    • Author(s)
      Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka, Y,Wakamura T, Fukuhara S, Mishima M, Kadotani H.
    • Journal Title

      Journal of Sleep Rrsecrch in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the presence of hypertension on the relationship between obstructive sleep apnoea and sleepiness.

    • Author(s)
      Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka, Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H.
    • Journal Title

      Journal of Sleep Rrsearch

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple four-variable screening tool for identification of patients with-disordered breathing.

    • Author(s)
      Takegami M, Hayashino Y, Chin K, 他6名
    • Journal Title

      Sleep in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on Item Response Theory.

    • Author(s)
      Takegami M, Suzukamo Y, Wakita T, Noguchi H, Chin K, 他7名
    • Journal Title

      Sleep Medicine in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 睡眠呼吸障害2010

    • Author(s)
      陳和夫
    • Organizer
      第20回日本呼吸ケア・リハビリテーション学会学術集会、教育講演12
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害2010

    • Author(s)
      陳和夫
    • Organizer
      第20回日本呼吸ケア・リビリテーション学会学術集会、教育講演12
    • Place of Presentation
      長崎(招待講演)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠呼吸障害と循環器疾患及びその関連病態2010

    • Author(s)
      陳和夫
    • Organizer
      日本睡眠学会第35回定期学術集会ランチョンセミナー5
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害と循環器疾患及びその関連病態2010

    • Author(s)
      陳和夫
    • Organizer
      日本睡眠学会第35回定期学術集会ランチョンセミナー5
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠呼吸障害の頻度、病態生理および合併症2010

    • Author(s)
      陳和夫
    • Organizer
      第55回日本透析医学会学術集会・総会「よくわかる透析科学2透析患者の見過ごされやすい合併症1.」
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害の頻度、病態生理および合併症2010

    • Author(s)
      陳和夫
    • Organizer
      第55回日本透析医学会学術集会・総会よくわかる透析科学2透析患者の見遇ごされやすい合併症1
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] hrelin levels in patients with obstructive sleep apnea before and after CPAP treatment. 2009 International Symposium on Ghrelin.2009

    • Author(s)
      Chin K, Takahashi K, Akamizu T, Oga T, Chihara Y, Harada Y, Handa T Tsuboi T, Mishima M, Kangawa K.
    • Organizer
      The 10th Anniversary of Discovery of Ghrelin.
    • Place of Presentation
      Tokyo International Forum (Hall B5) Tokyo, Japan
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生活習慣病の発症における睡眠の役割各生活習慣病(高血圧、耐糖能異常、メタボリックシンドロームなど)の疫学も含めて。睡眠と生活習慣病2009

    • Author(s)
      陳和夫、小賀徹、原田有香
    • Organizer
      日本睡眠学会第34回定期学術集会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠呼吸障害と呼吸・循環生理2009

    • Author(s)
      陳和夫
    • Organizer
      日本麻酔科学会第56回学術集会:招待講演17
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2009-08-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害と呼吸・循環生理2009

    • Author(s)
      陳和夫
    • Organizer
      招待講演17.日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸ポートピアホテル、神戸
    • Year and Date
      2009-08-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association between obstructive sleep apnea, metabolic syndrome and sleep duration with an actigraph in an urban male working population.2009

    • Author(s)
      陳和夫
    • Organizer
      THE XIth OXFORD CONFERENCE ON MODELING AND CONTROL OF BREATHING-NEW FRONTIERS IN RESPIRATORY CONTROL : Session 9. Sleep apnea.
    • Place of Presentation
      Nara Prefectural New Public Hall(奈良)
    • Year and Date
      2009-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Association between obstructive sleep apnea, metabolic syndrome and sleep duration with an actigraph in an urban male working population. Session 9. Sleep apnea.2009

    • Author(s)
      Chin K.
    • Organizer
      THE XIth OXFORD CONFERENCE ON MODELING AND CONTROL OF BREATHING-NEW FRONTIERS IN RESPIRATORY CONTROL
    • Place of Presentation
      Nara Prefectural New Public Hall, Nara, Japan
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢性睡眠時無呼吸症候群の病態と新規ストラテジー2009

    • Author(s)
      陳和夫
    • Organizer
      第30回生涯教育講演会(呼吸器セミナー)、日本呼吸器学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害と呼吸管理2009

    • Author(s)
      陳和夫
    • Organizer
      第31回日本呼吸療法学会学術総会
    • Place of Presentation
      天童ホテル(山形)
    • Year and Date
      2009-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 睡眠呼吸障害と呼吸管理2009

    • Author(s)
      陳和夫
    • Organizer
      第31回日本呼吸療法学会学術総会2009
    • Place of Presentation
      天童ホテル、天童、山形
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Obstructive sleep apnea and metabolic syndrome. APSC-JCS Joint Session : Sleep disordered breathing and cardiovascular disease.2009

    • Author(s)
      陳和夫
    • Organizer
      17th Asian Pacific Congress of Cardiology.
    • Place of Presentation
      International Conference Hall(京都)
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Obstructive sleep apnea and metabolic syndrome. APSC-JCS Joint Session : Sleep disordered breathing and cardiovascular disease.2009

    • Author(s)
      Chin K.
    • Organizer
      17th Asian Pacific Congress of Cardiology
    • Place of Presentation
      International Conference Hall, Kyoto, Japan
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中枢性睡眠時無呼吸症候群の病態と新規ストラテジー2009

    • Author(s)
      陳和夫
    • Organizer
      第30回生涯教育講演会(呼吸器セミナー)、日本呼吸器学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sleep-disordred breathing in Japan : Symposium Sleep-disordered breathing in Asia and elsewhere-Diagnosis and treatment.2008

    • Author(s)
      陳和夫
    • Organizer
      13th Congress of The Asian Pacific Society of Respirology.
    • Place of Presentation
      Bangkok, Thailand.
    • Year and Date
      2008-11-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Sleep-disordred breathing in Japan : Symposium Sleep-disordered breathing in Asia and elsewhere-Diagnosis and treatment.2008

    • Author(s)
      Chin K
    • Organizer
      13^<th> Congress of The Asian Pacific Society of Respirology
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長期NPVを施行した拘束性胸郭疾患174症例の予後調査.2008

    • Author(s)
      陳和夫, 他9名
    • Organizer
      第18回呼吸ケア・リハビリテーション学会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 企業検診における睡眠呼吸障害メタボリツク症候群と睡眠時間の関連2008

    • Author(s)
      陳和夫, 他12名
    • Organizer
      第33回日本睡眠学会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] NPPV(非侵襲的陽圧換気療法)ガイドライン.呼吸管理・睡眠時無呼吸ガイドライン2008

    • Author(s)
      陳和夫
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2008-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] NPPV(非侵襲的陽圧換気療法)ガイドライン. 呼吸管理・睡眠時無呼吸ガイドライン.2008

    • Author(s)
      陳和夫
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2008-06-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] The influence of sleep-disordered breathing on the occurrence of metabolic syndrome from a Japanese male working population.2008

    • Author(s)
      Chin K, 他12名
    • Organizer
      International Conference of ATS.
    • Place of Presentation
      Tronto, U.S.A.
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report
  • [Book] 生活習慣病:各種疾患と睡眠障害(基礎からの睡眠医学)2010

    • Author(s)
      陳和夫
    • Total Pages
      456
    • Publisher
      名古屋大学出版会
    • Related Report
      2010 Final Research Report
  • [Book] SDB発症の病態生理(睡眠呼吸障害(SDB)を見逃さないために)2010

    • Author(s)
      陳和夫
    • Total Pages
      252
    • Publisher
      診断と治療社
    • Related Report
      2010 Final Research Report
  • [Book] 睡眠時無呼吸症候群・肥満低換気症候群(日本臨牀68巻増刊号2(肥満症第2版))2010

    • Author(s)
      陳和夫
    • Total Pages
      776
    • Publisher
      日本臨牀社
    • Related Report
      2010 Final Research Report
  • [Book] 各種疾患と睡眠障害。3.生活習慣病:基礎からの睡眠医学2010

    • Author(s)
      陳和夫
    • Publisher
      名古屋大学出版会
    • Related Report
      2010 Annual Research Report
  • [Book] SDB発症の病態生理:睡眠呼吸障害(SDB)を見逃さないために2010

    • Author(s)
      陳和夫
    • Publisher
      診断と治療社
    • Related Report
      2010 Annual Research Report
  • [Book] 「睡眠時無呼吸症候群・肥満低換気症候群」 日本臨牀68巻増刊号2 (肥満症第2版)2010

    • Author(s)
      陳和夫
    • Total Pages
      776
    • Publisher
      睡眠時無呼吸症候群・肥満低換気症候群
    • Related Report
      2009 Annual Research Report
  • [Book] 肥満と生活習慣病(睡眠学:日本睡眠学会編)2008

    • Author(s)
      陳和夫
    • Total Pages
      735
    • Publisher
      朝倉書店
    • Related Report
      2010 Final Research Report
  • [Book] 肥満と生活習慣病. 睡眠学 : 日本睡眠学会編2008

    • Author(s)
      陳和夫
    • Total Pages
      735
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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