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Role or tetraspanins in angiogenesis and lymphangiogenesis

Research Project

Project/Area Number 20590922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

TAKAHASHI Ryo (2010)  大阪大学, 医学部附属病院, 医員 (10546865)

川瀬 一郎 (2008-2009)  Osaka University, 医学系研究科, 教授 (10161324)

Co-Investigator(Kenkyū-buntansha) TAKEDA Yoshito  大阪大学, 医学系・研究科, 助教 (40452388)
TACHIBANA Isao  大阪大学, 医学系・研究科, 講師 (60324761)
高橋 良  大阪大学, 医学部附属病院, 医員(臨床研究) (10546865)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsテトラスパニン / 肺癌 / 血管新生 / リンパ管新生 / CD9 / CD151
Research Abstract

We previously reported that tetraspanins are involved in the progression of inflammation and COPD through regulating cell activation. Here, we found that CD151 is involved in angiogenesis, and that CD9 is involved not only in angiogenesis, but also lymphangiogenesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Diminished metastasis in Tetraspanin CD151 Knockout mice2011

    • Author(s)
      Takeda Y et al
    • Journal Title

      Blood

      Volume: 118(2) Pages: 464-72

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 分子オーガナイザCD9とCD81ダブルノックアウトマウスにおける肺気腫と骨量減少2010

    • Author(s)
      立花功
    • Journal Title

      呼吸

      Volume: 29 Pages: 194-210

    • Related Report
      2010 Final Research Report
  • [Journal Article] マクロファージの活性化におけるCD9(tetraspanin)の役割2010

    • Author(s)
      立花功、鈴木真優美、武田吉人, 他
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 214-220

    • NAID

      40017012899

    • Related Report
      2010 Final Research Report
  • [Journal Article] COPDにおけるテトラスパニンの役割2010

    • Author(s)
      武田吉人、鈴木真優美、立花功
    • Journal Title

      The Lung perspective

      Volume: 18 Pages: 291-298

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, Takeda Y et al
    • Journal Title

      J Immunol

      Volume: 182 Pages: 6485-6493

    • Related Report
      2010 Final Research Report
  • [Journal Article] COPDモデルとしてのテトラスパニンCD9/ CD81ダブルノックアウトマウスの解析2009

    • Author(s)
      武田吉人
    • Journal Title

      International Review of Asthma & COPD

      Volume: 11 Pages: 31-36

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation2009

    • Author(s)
      Suzuki M, Tachibana I, Takeda Y
    • Journal Title

      J Immunol. 15

      Pages: 6485-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COPDモデルとしてのテトラスパニンCD9/CD81ダブルノックアウトマウスの解析2009

    • Author(s)
      武田吉人, 立花功, 川瀬一郎
    • Journal Title

      International Review of Asthma & COPD 11

      Pages: 31-36

    • Related Report
      2009 Annual Research Report
  • [Journal Article] High frequencies of less differentiated and more proliferative WT1-specific CD8 T cells in bone marrow in tumor-bearing patients : An important role of bone marrow as a secondary lymphoid organ2009

    • Author(s)
      Murao A, Oka Y
    • Journal Title

      Cancer Sci. (Equb ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tetraspanin CD9 link VEGFR-3 and integrins in physiological and pathological lymphangiogenesis2011

    • Author(s)
      武田吉人
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Tetraspanin CD9 functions as" linkers" of VEGFR-3 signaling in the regulation of physiological and pathological lymphangiogenesis2011

    • Author(s)
      武田吉人
    • Organizer
      FASEB Summer Research Conference
    • Year and Date
      2011-07-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Tetraspanin CD9 link VEGFR-3 and integrins in physiological and pathological lymphangiogenesis2010

    • Author(s)
      武田吉人
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Tetraspanin CD9 functions as" linkers" of VEGFR-3 signaling in the regulation of physiological and pathological lymphangiogenesis2010

    • Author(s)
      武田吉人
    • Organizer
      第4回Tetraspanins Meeting
    • Place of Presentation
      London
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] リンパ管新生におけるCD9の役割2010

    • Author(s)
      武田吉人
    • Organizer
      第4回ヨーロッパテトラスパニンミーティング
    • Place of Presentation
      バーミンガム大学(イギリス)
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺がんと肺の炎症における分子オーガナイザCD9とCD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 肺の炎症と気腫化におけるテトラスパニンCD9/ CD81の役割2009

    • Author(s)
      立花功
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] COPD患者の末梢血単球における tetraspanin の発現解析2009

    • Author(s)
      周博, 武田吉人
    • Organizer
      第49回 日本呼吸器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/www/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_8/research_c.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/imed3/lab_8/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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