| Project/Area Number |
20590932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IWASAKI Yoshinobu Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (00203373)
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| Co-Investigator(Kenkyū-buntansha) |
MARUNAKA Yoshinori 京都府立医科大学, 医学研究科, 教授 (00127036)
NIISATO Naomi 京都府立医科大学, 医学研究科, 准教授 (00237645)
ARIMOTO Taichiro 京都府立医科大学, 医学研究科, 講師 (30457965)
UEDA Mikio 京都府立医科大学, 医学研究科, 助教 (40457966)
HOSOGI Shigekuni 京都府立医科大学, 医学研究科, 助教 (30433254)
細木 誠之 京都府立医科大学, 医学研究科, 助教 (30405261)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | TLR / エンドトキシン肺損傷 / CD14 / 肺胞上皮 / アポトーシス / シグナリングアッセイ / 肺水腫 |
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| Research Abstract |
In the experimental model of endotoxin-induced acute lung injury using rats, TLR4 gene and protein expression were found followed by apoptosis of alveolar epithelia. Soluble CD14 accelerated apoptosis of alveolar epithelia by activating TLR4. Inactivation of soluble CD14 reduced alveolar epithelial damage.
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